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Year Number of Results
1985 2
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1987 16
1988 14
1989 14
1990 5
1991 5
1992 5
1993 4
1994 1
1995 3
1997 3
1998 3
1999 6
2000 5
2001 4
2002 6
2003 1
2004 2
2005 10
2006 13
2007 20
2008 13
2009 22
2010 19
2011 17
2012 17
2013 9
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2015 8
2016 6
2017 7
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2020 9
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2023 10
2024 9

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307 results

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Page 1
Pharmacokinetics of difloxacin after intravenous, intramuscular, and intragastric administration to horses.
Fernández-Varón E, Cárceles CM, Marín P, Martos N, Escudero E, Ayala I. Fernández-Varón E, et al. Am J Vet Res. 2006 Jun;67(6):1076-81. doi: 10.2460/ajvr.67.6.1076. Am J Vet Res. 2006. PMID: 16740105 Free article. Clinical Trial.
A high-performance liquid chromatography assay with fluorescence detection was used to determine plasma difloxacin concentrations. Pharmacokinetic parameters of difloxacin were analyzed. ...Mean half-life for difloxacin administered IV, IM, and IG was 2.66, 5 …
A high-performance liquid chromatography assay with fluorescence detection was used to determine plasma difloxacin concentrations. Ph …
Plasma disposition and tissue depletion of difloxacin and its metabolite sarafloxacin in the food producing animals, chickens for fattening.
Anadón A, Suárez FH, Martínez MA, Castellano V, Martínez M, Ares I, Ramos E, Gamboa F, Martínez-Larrañaga MR. Anadón A, et al. Food Chem Toxicol. 2011 Feb;49(2):441-9. doi: 10.1016/j.fct.2010.11.021. Epub 2010 Nov 23. Food Chem Toxicol. 2011. PMID: 21108984
Chickens were used to investigate plasma disposition of difloxacin after single intravenous (IV) and oral dose (10 mg/kg body weight (BW)) and to study residue depletion of difloxacin and its major metabolite sarafloxacin after multiple oral doses (10 mg difloxac …
Chickens were used to investigate plasma disposition of difloxacin after single intravenous (IV) and oral dose (10 mg/kg body weight …
Stoichiometry-Selective Antagonism of α4β2 Nicotinic Acetylcholine Receptors by Fluoroquinolone Antibiotics.
Sanders VR, Sweeney A, Topf M, Millar NS. Sanders VR, et al. ACS Chem Neurosci. 2022 Jun 15;13(12):1805-1817. doi: 10.1021/acschemneuro.2c00200. Epub 2022 Jun 3. ACS Chem Neurosci. 2022. PMID: 35657695 Free PMC article.
However, all of the fluoroquinolone antibiotics examined (ciprofloxacin, enoxacin, enrofloxacin, difloxacin, norfloxacin, pefloxacin, and sparfloxacin) were significantly more potent inhibitors of (alpha4)(2)(beta2)(3) nAChRs than of (alpha4)(3)(beta2)(2) nAChRs. ...
However, all of the fluoroquinolone antibiotics examined (ciprofloxacin, enoxacin, enrofloxacin, difloxacin, norfloxacin, pefloxacin, …
Evaluation of the bactericidal activity of temafloxacin.
Jacobs MR. Jacobs MR. Am J Med. 1991 Dec 30;91(6A):31S-34S. doi: 10.1016/0002-9343(91)90307-j. Am J Med. 1991. PMID: 1662893 Review.
Similar time-kill curves against Escherichia coli were observed for temafloxacin, ciprofloxacin, and difloxacin. Time-kill kinetics of temafloxacin against methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-sensitive S. aureus (MSSA) were superior to those …
Similar time-kill curves against Escherichia coli were observed for temafloxacin, ciprofloxacin, and difloxacin. Time-kill kinetics o …
Comparison of pharmacodynamic and pharmacokinetic indices of efficacy for 5 fluoroquinolones toward pathogens of dogs and cats.
Boothe DM, Boeckh A, Simpson RB, Dubose K. Boothe DM, et al. J Vet Intern Med. 2006 Nov-Dec;20(6):1297-306. doi: 10.1892/0891-6640(2006)20[1297:copapi]2.0.co;2. J Vet Intern Med. 2006. PMID: 17186841 Free article.
The pattern of Cmax/MIC was generally enrofloxacin+ciprofloxacin > or = enrofloxacin or ciprofloxacin > or = marbofloxacin > or = orbifloxacin > or = difloxacin; and for AUIC/ MIC, enrofloxacin+ciprofloxacin > or = marbofloxacin > or = ciprofloxacin > …
The pattern of Cmax/MIC was generally enrofloxacin+ciprofloxacin > or = enrofloxacin or ciprofloxacin > or = marbofloxacin > or = o …
Old Drugs with New Tricks: Efficacy of Fluoroquinolones to Suppress Replication of Flaviviruses.
Scroggs SLP, Andrade CC, Chinnasamy R, Azar SR, Schirtzinger EE, Garcia EI, Arterburn JB, Hanley KA, Rossi SL. Scroggs SLP, et al. Viruses. 2020 Sep 13;12(9):1022. doi: 10.3390/v12091022. Viruses. 2020. PMID: 32933138 Free PMC article.
Repurposing FDA-approved compounds could provide the fastest route to alleviate the burden of disease caused by flaviviruses. In this study, three fluoroquinolones, enoxacin, difloxacin and ciprofloxacin, curtailed replication of flaviviruses Zika (ZIKV), dengue (DENV), La …
Repurposing FDA-approved compounds could provide the fastest route to alleviate the burden of disease caused by flaviviruses. In this study, …
Comparative activity of the 4-quinolones.
Phillips I, King A. Phillips I, et al. Rev Infect Dis. 1988 Jan-Feb;10 Suppl 1:S70-6. doi: 10.1093/clinids/10.supplement_1.s70. Rev Infect Dis. 1988. PMID: 3279501 Review.
Minimal inhibitory concentrations (MICs) of the 4-quinolones ciprofloxacin, enoxacin, norfloxacin, ofloxacin, pefloxacin, difloxacin, A-56620, and CI-934 are consistent world-wide, with allowances for differences in acquired resistance. ...
Minimal inhibitory concentrations (MICs) of the 4-quinolones ciprofloxacin, enoxacin, norfloxacin, ofloxacin, pefloxacin, difloxacin, …
Pharmacokinetics of difloxacin in healthy and E. coli-infected broiler chickens.
Abo El-Ela FI, Radi AM, El-Banna HA, El-Gendy AA, Tohamy MA. Abo El-Ela FI, et al. Br Poult Sci. 2014;55(6):830-6. doi: 10.1080/00071668.2014.960803. Epub 2014 Oct 3. Br Poult Sci. 2014. PMID: 25229385
After intravenous injection of difloxacin, the serum concentration-time curves were best described by a two-compartment open model. ...These results show that administration of a therapeutic dose of difloxacin is effective in the treatment of E. coli infection in ch …
After intravenous injection of difloxacin, the serum concentration-time curves were best described by a two-compartment open model. . …
Population Pharmacokinetics of Difloxacin in Crucian Carp (Carassius auratus) after a Single Oral Administration.
Ma KL, Yang F, Zhang M, Chen JC, Duan MH, Li ZE, Dai Y, Liu Y, Jin YG, Yang F. Ma KL, et al. Vet Sci. 2023 Jun 27;10(7):416. doi: 10.3390/vetsci10070416. Vet Sci. 2023. PMID: 37505822 Free PMC article.
This study aimed to investigate the population pharmacokinetics of difloxacin in crucian carp (Carassius auratus) orally provided a single dose of 20 mg/kg body weight (BW). ...Based on the calculated free AUC/MIC values, the current oral dose of difloxacin (20 mg/k …
This study aimed to investigate the population pharmacokinetics of difloxacin in crucian carp (Carassius auratus) orally provided a s …
An immunochromatographic strip sensor for marbofloxacin residues.
Yang X, Li Q, Kwee S, Yang J, Zhang Q, Hu X. Yang X, et al. PLoS One. 2024 Mar 29;19(3):e0299709. doi: 10.1371/journal.pone.0299709. eCollection 2024. PLoS One. 2024. PMID: 38551994 Free PMC article.
The cross-reactivity (CR) of the MBF ICSAs to Ofloxacin (OFL), enrofloxacin (ENR), norfloxacin (NOR), and Ciprofloxacin (CIP) were 60.98%, 32.05%, 22.94%, and 23.58%, respectively. The CR for difloxacin (DIF) and sarafloxacin (SAR) was less than 0.1%. The recovery rates of …
The cross-reactivity (CR) of the MBF ICSAs to Ofloxacin (OFL), enrofloxacin (ENR), norfloxacin (NOR), and Ciprofloxacin (CIP) were 60.98%, 3 …
307 results