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Chlordecone alcohol formation in the Mongolian gerbil (Meriones unguiculatus): a model for human metabolism of chlordecone (kepone).
Houston TE, Mutter LC, Blanke RV, Guzelian PS. Houston TE, et al. Fundam Appl Toxicol. 1981 May-Jun;1(3):293-8. doi: 10.1016/s0272-0590(81)80132-7. Fundam Appl Toxicol. 1981. PMID: 6192032
Rats given [3H]-chlordecone alcohol excreted twice as much (80%) of the compound in stool after three days as compared to gerbils (40%), while the latter species accumulated three times more chlordecone alcohol in the liver than did the former. An unex …
Rats given [3H]-chlordecone alcohol excreted twice as much (80%) of the compound in stool after three days as compared to gerb …
Demonstration of major metabolic pathways for chlordecone (kepone) in humans.
Fariss MW, Blanke RV, Saady JJ, Guzelian PS. Fariss MW, et al. Drug Metab Dispos. 1980 Nov-Dec;8(6):434-8. Drug Metab Dispos. 1980. PMID: 6161768
The hypothesis that liver is the site of the previously demonstrated chlordecone alcohol formation in man was tested. Human bile obtained from chlordecone-poisoned factory workers contained substantial amounts of free chlordecone, but little free chlordecone …
The hypothesis that liver is the site of the previously demonstrated chlordecone alcohol formation in man was tested. Human bi …
Chlordecone metabolism in the pig.
Soine PJ, Blanke RV, Schwartz CC. Soine PJ, et al. Toxicol Lett. 1983 Jun;17(1-2):35-41. doi: 10.1016/0378-4274(83)90032-2. Toxicol Lett. 1983. PMID: 6194575
The biotransformation of chlordecone (CD) to chlordecone alcohol (CDOH) occurs in man and gerbils but not in rats, guinea pigs and hamsters [1, 2]. ...
The biotransformation of chlordecone (CD) to chlordecone alcohol (CDOH) occurs in man and gerbils but not in rats, guinea pigs …
Excretion of chlordecone by the gastrointestinal tract: evidence for a nonbiliary mechanism.
Boylan JJ, Cohn WJ, Egle JL Jr, Blanke RV, Guzelian PS. Boylan JJ, et al. Clin Pharmacol Ther. 1979 May;25(5 Pt 1):579-85. doi: 10.1002/cpt1979255part1579. Clin Pharmacol Ther. 1979. PMID: 86403
We found in a single subject that equal amounts of chlordecone and of its reduced metabolite, chlordecone alcohol, were excreted in bile at a rate four times as great as in stool. When biliary contents were diverted from the intestine through a T tube, fecal excreti …
We found in a single subject that equal amounts of chlordecone and of its reduced metabolite, chlordecone alcohol, were excret …
Effects of chlordecone and chlordecone alcohol on isolated ovine erythrocytes.
Soileau SD, Moreland DE. Soileau SD, et al. J Toxicol Environ Health. 1988;24(2):237-49. doi: 10.1080/15287398809531157. J Toxicol Environ Health. 1988. PMID: 2455063
Chlordecone (CHLO, 14-30 microM) and chlordecone alcohol (CHLO ALC, 10-23 microM) altered the permeability of isolated ovine erythrocytes as evidenced by a concentration- and time-dependent induction of K+ efflux and hemolysis. ...
Chlordecone (CHLO, 14-30 microM) and chlordecone alcohol (CHLO ALC, 10-23 microM) altered the permeability of isolated ovine e …
Effects of chlordecone and its alteration products on isolated rat liver mitochondria.
Soileau SD, Moreland DE. Soileau SD, et al. Toxicol Appl Pharmacol. 1983 Jan;67(1):89-99. doi: 10.1016/0041-008x(83)90247-8. Toxicol Appl Pharmacol. 1983. PMID: 6189267
Partitioning of chlordecone, chlordecone alcohol, monohydrochlordecone, and dihydrochlordecone (2 to 100 microM) into isolated rat liver mitochondria altered the permeability properties of the inner membrane as evidenced by: inhibition of valinomycin-induced swellin …
Partitioning of chlordecone, chlordecone alcohol, monohydrochlordecone, and dihydrochlordecone (2 to 100 microM) into isolated …
Purification and characterization of chlordecone reductase from human liver.
Molowa DT, Shayne AG, Guzelian PS. Molowa DT, et al. J Biol Chem. 1986 Sep 25;261(27):12624-7. J Biol Chem. 1986. PMID: 2427522 Free article.
However, analyses of liver cytosolic samples on immunoblots developed with anti-chlordecone reductase antibodies revealed that immunoreactive proteins were present only in those mammalian species that convert chlordecone to chlordecone alcohol in vivo (man, gerbil, …
However, analyses of liver cytosolic samples on immunoblots developed with anti-chlordecone reductase antibodies revealed that immunoreactiv …
Characterization of a unique aldo-keto reductase responsible for the reduction of chlordecone in the liver of the gerbil and man.
Molowa DT, Wrighton SA, Blanke RV, Guzelian PS. Molowa DT, et al. J Toxicol Environ Health. 1986;17(4):375-84. doi: 10.1080/15287398609530832. J Toxicol Environ Health. 1986. PMID: 2420999
It has been established that the major metabolic pathway for chlordecone (CD) (Kepone) both in humans and in the Mongolian gerbil is bioreduction of this organochlorine pesticide to chlordecone alcohol (CDOH) in the liver. In the present study we developed a gas-liq …
It has been established that the major metabolic pathway for chlordecone (CD) (Kepone) both in humans and in the Mongolian gerbil is bioredu …
Isolation and characterization of cloned cDNAs encoding human liver chlordecone reductase.
Winters CJ, Molowa DT, Guzelian PS. Winters CJ, et al. Biochemistry. 1990 Jan 30;29(4):1080-7. doi: 10.1021/bi00456a034. Biochemistry. 1990. PMID: 2187532
Chlordecone (Kepone), a toxic organochlorine pesticide, undergoes bioreduction to chlordecone alcohol in human liver. This reaction is controlled by a cytosolic enzyme, chlordecone reductase (CDR), which may be of the aldo-keto reductase family of xenobiotic metabol …
Chlordecone (Kepone), a toxic organochlorine pesticide, undergoes bioreduction to chlordecone alcohol in human liver. This rea …