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Synthesis of casimiroin and optimization of its quinone reductase 2 and aromatase inhibitory activities.
Maiti A, Reddy PV, Sturdy M, Marler L, Pegan SD, Mesecar AD, Pezzuto JM, Cushman M. Maiti A, et al. J Med Chem. 2009 Apr 9;52(7):1873-84. doi: 10.1021/jm801335z. J Med Chem. 2009. PMID: 19265439 Free PMC article.
An efficient method has been developed to synthesize casimiroin (1), a component of the edible fruit of Casimiroa edulis, on a multigram scale in good overall yield. ...
An efficient method has been developed to synthesize casimiroin (1), a component of the edible fruit of Casimiroa edulis, on a multig …
Synthesis of carbon-11-labeled casimiroin analogues as new potential PET agents for imaging of quinone reductase 2 and aromatase expression in breast cancer.
Wang M, Gao M, Miller KD, Sledge GW, Hutchins GD, Zheng QH. Wang M, et al. Steroids. 2010 Dec;75(12):967-73. doi: 10.1016/j.steroids.2010.06.004. Epub 2010 Jun 15. Steroids. 2010. PMID: 20558190
Carbon-11-labeled casimiroin analogues were first designed and synthesized as new potential PET agents for imaging of quinone reductase (QR) 2 and aromatase expression in breast cancer. [(11)C]casimiroin (6-[(11)C]methoxy-9-methyl-[1,3]dioxolo[4,5-h]quinolin-8(9H)-o …
Carbon-11-labeled casimiroin analogues were first designed and synthesized as new potential PET agents for imaging of quinone reducta …
Vasorelaxation by extracts of Casimiroa spp. in rat resistance vessels and pharmacological study of cellular mechanisms.
Froldi G, Bertin R, Secchi E, Zagotto G, Martínez-Vázquez M, García-Argaéz A. Froldi G, et al. J Ethnopharmacol. 2011 Apr 12;134(3):637-43. doi: 10.1016/j.jep.2011.01.008. Epub 2011 Jan 12. J Ethnopharmacol. 2011. PMID: 21236328
The methanolic extract of Casimiroa pubescens seeds (Cp12) was also studied by H-NMR and LC-MS (ESI-TOF) for the determination of casimiroin and zapotin. RESULTS: The hexanic and methanolic extracts of Casimiroa spp. (20 mug/ml) showed vasorelaxation in arterial tissues pr …
The methanolic extract of Casimiroa pubescens seeds (Cp12) was also studied by H-NMR and LC-MS (ESI-TOF) for the determination of casimir …