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Year Number of Results
1990 1
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1994 4
1995 1
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2022 1
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Cost-effectiveness of acupuncture versus standard care for pelvic and low back pain in pregnancy: A randomized controlled trial.
Nicolian S, Butel T, Gambotti L, Durand M, Filipovic-Pierucci A, Mallet A, Kone M, Durand-Zaleski I, Dommergues M. Nicolian S, et al. PLoS One. 2019 Apr 22;14(4):e0214195. doi: 10.1371/journal.pone.0214195. eCollection 2019. PLoS One. 2019. PMID: 31009470 Free PMC article. Clinical Trial.
Average total costs were higher in the control group (2947) than in the acupuncture group (2635, delta = -312, 95% CI: -966 to +325), resulting from the higher indirect costs of absenteeism and presenteeism. ...
Average total costs were higher in the control group (2947) than in the acupuncture group (2635, delta = -312, 95% CI: -966 to …
Antiviral Therapy Improves Hepatocellular Cancer Survival.
Nguyen N, Patel K, Uhelski AC, Waters B, Weir A. Nguyen N, et al. Fed Pract. 2021 Aug;38(Suppl 3):e58-e63. doi: 10.12788/fp.0165. Fed Pract. 2021. PMID: 34733098 Free PMC article.
In a multivariate analysis accounting for severity of liver disease, treated patients had an improved 5-year OS rate, median 1338 days (95% CI, 966-3202) when compared with untreated patients whose median OS was 452 days (95% CI, 242-853) (P = .0005). ...
In a multivariate analysis accounting for severity of liver disease, treated patients had an improved 5-year OS rate, median 1338 days (95% …
CI-966, a GABA uptake inhibitor, antagonizes ischemia-induced neuronal degeneration in the gerbil.
Phillis JW. Phillis JW. Gen Pharmacol. 1995 Sep;26(5):1061-4. doi: 10.1016/0306-3623(94)00270-w. Gen Pharmacol. 1995. PMID: 7557251
CI-966 reduced the extent of stroke injury as assessed by locomotor activity and measurement of hippocampal CA1 pyramidal cell injury. 4. It is proposed that enhancement of extracellular GABA levels during ischemia accounts for the cerebroprotective actions of CI
CI-966 reduced the extent of stroke injury as assessed by locomotor activity and measurement of hippocampal CA1 pyramidal cell
Tiagabine, SK&F 89976-A, CI-966, and NNC-711 are selective for the cloned GABA transporter GAT-1.
Borden LA, Murali Dhar TG, Smith KE, Weinshank RL, Branchek TA, Gluchowski C. Borden LA, et al. Eur J Pharmacol. 1994 Oct 14;269(2):219-24. doi: 10.1016/0922-4106(94)90089-2. Eur J Pharmacol. 1994. PMID: 7851497
We have now determined the potency of four of these compounds, SK&F 89976-A (N-(4,4-diphenyl-3-butenyl)-3-piperidinecarboxylic acid), tiagabine ((R)-1-[4,4-bis(3-methyl-2-thienyl)-3-butenyl]-3- piperidencarboxylic acid), CI-966 ([1-[2-[bis 4-(trifluoromethyl)phe …
We have now determined the potency of four of these compounds, SK&F 89976-A (N-(4,4-diphenyl-3-butenyl)-3-piperidinecarboxylic acid), ti …
Pharmacokinetics, mass balance, and induction potential of a novel GABA uptake inhibitor, CI-966 HCl, in laboratory animals.
Radulovic LL, Bockbrader HN, Chang T. Radulovic LL, et al. Pharm Res. 1993 Oct;10(10):1442-5. doi: 10.1023/a:1018915123542. Pharm Res. 1993. PMID: 8272405
CI-966 exhibits anticonvulsant properties in various animal models. ...Following iv administration of the same respective doses, elimination t1/2 in dogs and rats averaged 1.2 and 4.5 hr. Absolute oral bioavailability of CI-966 was 100% in both species
CI-966 exhibits anticonvulsant properties in various animal models. ...Following iv administration of the same respective dose
Systemic CI-966, a new gamma-aminobutyric acid uptake blocker, enhances gamma-aminobutyric acid action in CA1 pyramidal layer in situ.
Ebert U, Krnjević K. Ebert U, et al. Can J Physiol Pharmacol. 1990 Sep;68(9):1194-9. doi: 10.1139/y90-179. Can J Physiol Pharmacol. 1990. PMID: 2276082
A new potent, blood-brain barrier permeable gamma-aminobutyric acid (GABA) uptake blocker, 1-[2-[bis[4-(trifluoromethyl)-phenyl]methoxy]ethyl]-1,2,5,6- tetrahydro-3-pyridinecarboxylic acid (CI-966) was administered systemically by i.p. injection (5 mg/kg) in Sprague …
A new potent, blood-brain barrier permeable gamma-aminobutyric acid (GABA) uptake blocker, 1-[2-[bis[4-(trifluoromethyl)-phenyl]methoxy]ethy …
GABA potentiation: a logical pharmacological approach for the treatment of acute ischaemic stroke.
Green AR, Hainsworth AH, Jackson DM. Green AR, et al. Neuropharmacology. 2000 Jul 10;39(9):1483-94. doi: 10.1016/s0028-3908(99)00233-6. Neuropharmacology. 2000. PMID: 10854894 Review.
This review examines the evidence that GABAergic function is acutely depressed following an ischaemic insult, and also reviews the data that suggest that increasing cerebral GABA concentration has a neuroprotective effect, as does the administration of some (but not all) GABAmime …
This review examines the evidence that GABAergic function is acutely depressed following an ischaemic insult, and also reviews the data that …
The estimated disease burden of norovirus in The Netherlands.
Verhoef L, Koopmans M, VAN Pelt W, Duizer E, Haagsma J, Werber D, VAN Asten L, Havelaar A. Verhoef L, et al. Epidemiol Infect. 2013 Mar;141(3):496-506. doi: 10.1017/S0950268812000799. Epub 2012 May 17. Epidemiol Infect. 2013. PMID: 22595489 Free PMC article.
The general population incidence was 3800/100 000 (95% CI 2670-5460), including 0.4 fatal cases/100 000,resulting in 1622 (95% CI 966-2650) disability-adjusted life-years in a population of 16.5 million [corrected].The updated burden of norovirus is over twofold hig …
The general population incidence was 3800/100 000 (95% CI 2670-5460), including 0.4 fatal cases/100 000,resulting in 1622 (95% CI
Associations between lifestyle and amyotrophic lateral sclerosis stratified by C9orf72 genotype: a longitudinal, population-based, case-control study.
Westeneng HJ, van Veenhuijzen K, van der Spek RA, Peters S, Visser AE, van Rheenen W, Veldink JH, van den Berg LH. Westeneng HJ, et al. Lancet Neurol. 2021 May;20(5):373-384. doi: 10.1016/S1474-4422(21)00042-9. Lancet Neurol. 2021. PMID: 33894192
Median BMI during the presymptomatic phase for the C9+ group was lower (-0.69 kg/m(2), 95% CI -1.24 to -0.13, p=0.015) and physical activity was similar (-348 metabolic equivalent of task [MET], 95% CI -966 to 270, p=0.27) to controls, whereas both the median BMI du …
Median BMI during the presymptomatic phase for the C9+ group was lower (-0.69 kg/m(2), 95% CI -1.24 to -0.13, p=0.015) and physical activity …
CalTAD is the Key Evaluation Tool for Measurement of Cephalic Fixation Position for Predicting Cut-Out in Geriatric Intertrochanteric Fracture Patients with Internal Fixations after Achieving Acceptable Reduction.
Yang YF, Huang JW, Gao XS. Yang YF, et al. Geriatr Orthop Surg Rehabil. 2022 Mar 29;13:21514593221083820. doi: 10.1177/21514593221083820. eCollection 2022. Geriatr Orthop Surg Rehabil. 2022. PMID: 35386949 Free PMC article.
We found that TAD (odds ratio (OR)=1.149; 95% confidence interval (CI), 1.00-1.32; P=.046) and CalTAD (OR=1.140; 95% CI, 1.00-1.30; P=.037) were risk factors for implant failures by univariate analysis, while only CalTAD (OR=1.200; 95% CI, 1.032-1.395; P=.018) was the independent …
We found that TAD (odds ratio (OR)=1.149; 95% confidence interval (CI), 1.00-1.32; P=.046) and CalTAD (OR=1.140; 95% CI, 1.00-1.30; P=.037) …
23 results