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Isolation and characterization of cetirizine degradation product: mechanism of cetirizine oxidation.
Dyakonov T, Muir A, Nasri H, Toops D, Fatmi A. Dyakonov T, et al. Pharm Res. 2010 Jul;27(7):1318-24. doi: 10.1007/s11095-010-0114-x. Epub 2010 Mar 31. Pharm Res. 2010. PMID: 20354769
The finding was verified by spiking of cetirizine degradation sample with cetirizine N-oxide reference standard. ...Selective oxidation of cetirizine and isolation/characterization of the oxidation product allowed the identification of the oxida …
The finding was verified by spiking of cetirizine degradation sample with cetirizine N-oxide reference standard. …
Rapid transformation of H(1)-antihistamines cetirizine (CET) and diphenhydramine (DPH) by direct peroxymonosulfate (PMS) oxidation.
He X, O'Shea KE. He X, et al. J Hazard Mater. 2020 Nov 5;398:123219. doi: 10.1016/j.jhazmat.2020.123219. Epub 2020 Jun 17. J Hazard Mater. 2020. PMID: 32768849
Addition of scavengers to the reaction mixture ruled out the involvement of hydroxyl radical (OH), sulfate radical (SO(4)(-)), singlet oxygen ((1)O(2)) and superoxide anion radical (O(2)(-)), indicating direct PMS oxidation as the predominant reaction path. Such a mechanism was f …
Addition of scavengers to the reaction mixture ruled out the involvement of hydroxyl radical (OH), sulfate radical (SO(4)(-)), singlet oxyge …