Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1992 2
1993 5
1994 8
1995 5
1996 4
1997 1
1998 1
1999 2
2021 1
2024 0

Text availability

Article attribute

Article type

Publication date

Search Results

29 results

Results by year

Filters applied: . Clear all
Page 1
BRL 46470A: a highly potent, selective and long acting 5-HT3 receptor antagonist with anxiolytic-like properties.
Blackburn TP, Baxter GS, Kennett GA, King FD, Piper DC, Sanger GJ, Thomas DR, Upton N, Wood MD. Blackburn TP, et al. Psychopharmacology (Berl). 1993;110(3):257-64. doi: 10.1007/BF02251279. Psychopharmacology (Berl). 1993. PMID: 7831418
In vivo, BRL 46470A showed anxiolytic-like activity in two animal models predictive of antianxiety effects-elevated X-maze and social interaction in rats. In both models, BRL 46470A showed significant activity over a wide dose-range following both oral …
In vivo, BRL 46470A showed anxiolytic-like activity in two animal models predictive of antianxiety effects-elevated X-maze and …
The effects of BRL 46470A, a novel 5-HT3 receptor antagonist, and lorazepam on psychometric performance and the EEG.
Link CG, Leigh TJ, Dennison JK. Link CG, et al. Br J Clin Pharmacol. 1993 Apr;35(4):395-9. doi: 10.1111/j.1365-2125.1993.tb04156.x. Br J Clin Pharmacol. 1993. PMID: 8485019 Free PMC article. Clinical Trial.
The effects of single doses of a novel 5-HT3 receptor antagonist, BRL 46470A (0.1 microgram, 0.01 mg, 1 mg or 50 mg) and lorazepam (2.5 mg) on psychometric performance and the EEG were investigated in a randomised, double-blind, crossover, placebo controlled study o …
The effects of single doses of a novel 5-HT3 receptor antagonist, BRL 46470A (0.1 microgram, 0.01 mg, 1 mg or 50 mg) and loraz …
Absence of amnestic effect of an anxiolytic 5-HT3 antagonist (BRL 46470A) injected into basolateral amygdala, as opposed to diazepam.
de Souza Silva M, Guimarães FS, Graeff FG, Tomaz C. de Souza Silva M, et al. Behav Brain Res. 1993 Dec 31;59(1-2):141-5. doi: 10.1016/0166-4328(93)90160-r. Behav Brain Res. 1993. PMID: 8155281
The animals were microinjected with DZP or BRL 46470A between 10 and 15 min before the learning trial. Retention testing 48 h later showed impaired retention in animals injected with DZP but not with BRL 46470A. These results show that BRL 46 …
The animals were microinjected with DZP or BRL 46470A between 10 and 15 min before the learning trial. Retention testing 48 h …
Effects of anxiety and memory of systemic and intra-amygdala injection of 5-HT3 receptor antagonist BRL 46470A.
Gargiulo PA, Viana MB, Graeff FG, Silva MA, Tomaz C. Gargiulo PA, et al. Neuropsychobiology. 1996;33(4):189-95. doi: 10.1159/000119276. Neuropsychobiology. 1996. PMID: 8840342
This study deals with the effects of the 5-HT3 receptor antagonist, BRL 46470A, on memory and anxiety, using the elevated T-maze. This method is useful for investigating the effects of anxiolytic drugs on memory, and the relationships between neural subsystems invol …
This study deals with the effects of the 5-HT3 receptor antagonist, BRL 46470A, on memory and anxiety, using the elevated T-ma …
Effects of acute administration of the 5-HT3 receptor antagonist, BRL 46470A, on the behaviour of mice in a two compartment light-dark box and during social interactions in their home cage and an unfamiliar neutral cage.
Gao B, Cutler MG. Gao B, et al. Neuropharmacology. 1992 Aug;31(8):743-8. doi: 10.1016/0028-3908(92)90035-n. Neuropharmacology. 1992. PMID: 1356251
Adult male CD1 mice received the 5-HT3 receptor antagonist, BRL 46470A, by intraperitoneal injection at three dose levels (2.5 mg/kg, 25 and 2.5 micrograms/kg). ...The behaviour of each mouse also was monitored for 5 min in a two compartment light-dark box. At all d …
Adult male CD1 mice received the 5-HT3 receptor antagonist, BRL 46470A, by intraperitoneal injection at three dose levels (2.5 …
Pre- and post-synaptic effects of the 5-HT3 agonist 2-methyl-5-HT on the 5-HT system in the rat brain.
Haddjeri N, Blier P. Haddjeri N, et al. Synapse. 1995 May;20(1):54-67. doi: 10.1002/syn.890200109. Synapse. 1995. PMID: 7624830
Concomitant microiontophoretic applications of the 5-HT3 antagonists BRL 46470A and S-zacopride, as well as their intravenous injection, did not antagonize the inhibitory effect of 5-HT and 2-methyl-5-HT. ...R-zacopride significantly reduced the duration of suppress …
Concomitant microiontophoretic applications of the 5-HT3 antagonists BRL 46470A and S-zacopride, as well as their intravenous …
Inhibition of NMDA-receptor mediated response in the rat medial prefrontal cortical pyramidal cells by the 5-HT3 receptor agonist SR 57227A and 5-HT: intracellular studies.
Liang X, Arvanov VL, Wang RY. Liang X, et al. Synapse. 1998 Jul;29(3):257-68. doi: 10.1002/(SICI)1098-2396(199807)29:3<257::AID-SYN8>3.0.CO;2-5. Synapse. 1998. PMID: 9635896
This action was markedly attenuated or completely blocked by the selective 5-HT3 receptor antagonists granisetron and BRL 46470A, but not other receptor antagonists. In addition to inhibiting NMDA-evoked responses, SR 57227A also depressed significantly pharmacologi …
This action was markedly attenuated or completely blocked by the selective 5-HT3 receptor antagonists granisetron and BRL 46470A …
Serotonin3 receptor agonists attenuate glutamate-induced firing in rat hippocampal CA1 pyramidal cells.
Zhang JY, Zeise ML, Wang RY. Zhang JY, et al. Neuropharmacology. 1994 Mar-Apr;33(3-4):483-91. doi: 10.1016/0028-3908(94)90079-5. Neuropharmacology. 1994. PMID: 7984287
This effect was markedly attenuated or completely blocked by the 5-HT3 receptor antagonist BRL 46470A but not by the nonspecific 5-HT1 and 5-HT2 receptor antagonist metergoline or by the 5-HT1A antagonist WAY 100478. ...Again, BRL 46470A but not meterg …
This effect was markedly attenuated or completely blocked by the 5-HT3 receptor antagonist BRL 46470A but not by the nonspecif …
The characterization of the effect of locally applied N-methylquipazine, a 5-HT3 receptor agonist, on extracellular dopamine levels in the anterior medial prefrontal cortex in the rat: an in vivo microdialysis study.
Kurata K, Ashby CR Jr, Oberlender R, Tanii Y, Kurachi M, Rini NJ, Strecker RE. Kurata K, et al. Synapse. 1996 Dec;24(4):313-21. doi: 10.1002/(SICI)1098-2396(199612)24:4<313::AID-SYN1>3.0.CO;2-G. Synapse. 1996. PMID: 10638822
The increase in extracellular DA levels in the AmPFc produced by 100 microM of NMQ was markedly attenuated by either the coadministration of tetrodotoxin (1 microM), which inhibits axonal impulse flow, or the depletion of extracellular Ca2+ by removing CaCl2 and adding EDTA to th …
The increase in extracellular DA levels in the AmPFc produced by 100 microM of NMQ was markedly attenuated by either the coadministration of …
Serotonin modulation of catalepsy induced by N(G)-nitro-L-arginine in mice.
Nucci-da-Silva LP, Guimarães FS, Del Bel EA. Nucci-da-Silva LP, et al. Eur J Pharmacol. 1999 Aug 20;379(1):47-52. doi: 10.1016/s0014-2999(99)00493-8. Eur J Pharmacol. 1999. PMID: 10499370
Prazosin (3 or 5 mg/kg), an alpha1-adrenoceptor antagonist, and endo-N-(8-methyl-8-azabicyclo[3.2.1]oct-3yl)-2,3-dihydro-3,3-dimet hyl-indole-1-carboxamide HCl (BRL-46470A, 0.05 or 0.5 mg/kg), a 5-HT3 receptor antagonist, did not interfere with L-NOARG-induced catal …
Prazosin (3 or 5 mg/kg), an alpha1-adrenoceptor antagonist, and endo-N-(8-methyl-8-azabicyclo[3.2.1]oct-3yl)-2,3-dihydro-3,3-dimet hyl-indol …
29 results