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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1993 3
1994 17
1995 21
1996 54
1997 66
1998 83
1999 92
2000 92
2001 82
2002 85
2003 79
2004 81
2005 59
2006 78
2007 89
2008 80
2009 43
2010 45
2011 48
2012 51
2013 43
2014 50
2015 50
2016 42
2017 30
2018 25
2019 24
2020 23
2021 17
2022 15
2023 15
2024 4

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1,457 results

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Page 1
7-Nitroindazole reduces L-DOPA-induced dyskinesias in non-human Parkinsonian primate.
Herrero MT, Yuste JE, Cuenca-Bermejo L, Almela P, Arenas-Betancur L, De Pablos V, Gonzalez-Cuello A, Del Bel E, Navarro-Zaragoza J, Fernández-Villalba E. Herrero MT, et al. Open Biol. 2023 May;13(5):220370. doi: 10.1098/rsob.220370. Epub 2023 May 17. Open Biol. 2023. PMID: 37192671 Free PMC article.
The objective of this study was to ascertain whether the NO synthase inhibitor, 7-nitroindazole (7-NI), is able to reduce L-DOPA-induced dyskinesias (LIDs) in a non-human primate model of PD chronically intoxicated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine ( …
The objective of this study was to ascertain whether the NO synthase inhibitor, 7-nitroindazole (7-NI), is able to reduce L-DO …
7-nitroindazole, but not L-NAME or aminoguanidine, attenuates anaphylactic hypotension in conscious rats.
Zhang W, Shibamoto T, Cui S, Takano H, Kurata Y. Zhang W, et al. Shock. 2009 Feb;31(2):201-6. doi: 10.1097/SHK.0b013e31817c05bc. Shock. 2009. PMID: 18497703
Effects of inhibition of NOS, iNOS, and nNOS by N-nitro-L-arginine methyl ester (L-NAME), aminoguanidine, and 7-nitroindazole, respectively, were determined on the antigen-induced systemic hypotension and portal hypertension in conscious Sprague-Dawley rats sensitiz …
Effects of inhibition of NOS, iNOS, and nNOS by N-nitro-L-arginine methyl ester (L-NAME), aminoguanidine, and 7-nitroindazole, …
Nitric oxide synthase inhibitors. Preclinical studies of potential use for treatment of opioid withdrawal.
Vaupel DB, Kimes AS, London ED. Vaupel DB, et al. Neuropsychopharmacology. 1995 Dec;13(4):315-22. doi: 10.1016/0893-133X(95)00138-4. Neuropsychopharmacology. 1995. PMID: 8747756 Review.
Insofar as hypertension is a component of opioid withdrawal in humans, the ability of 7-nitroindazole to attenuate morphine withdrawal in rats without eliciting a vasopressor response suggests that 7-nitroindazole may have human therapeutic potential. …
Insofar as hypertension is a component of opioid withdrawal in humans, the ability of 7-nitroindazole to attenuate morphine wi …
Anticonvulsant effects of 7-nitroindazole in rodents with reflex epilepsy may result from L-arginine accumulation or a reduction in nitric oxide or L-citrulline formation.
Smith SE, Man CM, Yip PK, Tang E, Chapman AG, Meldrum BS. Smith SE, et al. Br J Pharmacol. 1996 Sep;119(1):165-73. doi: 10.1111/j.1476-5381.1996.tb15690.x. Br J Pharmacol. 1996. PMID: 8872370 Free PMC article.
To investigate the role of nitric oxide in epilepsy we have studied the effects of agents which affect nitric oxide synthesis in sound-induced seizures in DBA/2 mice and in genetically epilepsy-prone (GEP) rats. 2. The neuronal selective nitric oxide synthase inhibitor, 7- …
To investigate the role of nitric oxide in epilepsy we have studied the effects of agents which affect nitric oxide synthesis in sound-induc …
7-Nitroindazole potentiates the antiseizure activity of some anticonvulsants in DBA/2 mice.
De Sarro G, Gareri P, Falconi U, De Sarro A. De Sarro G, et al. Eur J Pharmacol. 2000 Apr 14;394(2-3):275-88. doi: 10.1016/s0014-2999(00)00086-8. Eur J Pharmacol. 2000. PMID: 10771293
However, the therapeutic index of combined treatment with diazepam+7-nitroindazole, phenobarbital+7-nitroindazole or valproate+7-nitroindazole was more favourable than that of the diazepam+vehicle, phenobarbital+vehicle or valproate+vehic …
However, the therapeutic index of combined treatment with diazepam+7-nitroindazole, phenobarbital+7-nitroindazole …
The preferential nNOS inhibitor 7-nitroindazole and the non-selective one N(G)-nitro-L-arginine methyl ester administered alone or jointly with L-DOPA differentially affect motor behavior and monoamine metabolism in sham-operated and 6-OHDA-lesioned rats.
Czarnecka A, Konieczny J, Lenda T, Lorenc-Koci E. Czarnecka A, et al. Brain Res. 2015 Nov 2;1625:218-37. doi: 10.1016/j.brainres.2015.08.006. Epub 2015 Aug 28. Brain Res. 2015. PMID: 26319690
In the present study, we performed a comparative analysis of motor behavior (locomotor activity, catalepsy, rotational behavior) and monoamine metabolism in the striatum and substantia nigra of unilaterally sham-operated and 6-OHDA-lesioned rats treated with the preferential neur …
In the present study, we performed a comparative analysis of motor behavior (locomotor activity, catalepsy, rotational behavior) and monoami …
Selective pharmacological inhibition of distinct nitric oxide synthase isoforms.
Southan GJ, Szabó C. Southan GJ, et al. Biochem Pharmacol. 1996 Feb 23;51(4):383-94. doi: 10.1016/0006-2952(95)02099-3. Biochem Pharmacol. 1996. PMID: 8619882 Review.
Selective inhibition of NOS isoforms is achieved by: (a) targeting the differential co-factor (calmodulin or tetrahydrobiopterin) requirement of various NOS isoforms, and NOS; (b) targeting the differential substrate requirements of cells expressing various isoforms of NOS (L-arg …
Selective inhibition of NOS isoforms is achieved by: (a) targeting the differential co-factor (calmodulin or tetrahydrobiopterin) requiremen …
7-nitroindazol-loaded nanoemulsions: Preparation, characterization and its improved inhibitory effect on nitric oxide synthase-1.
Barp CG, Mendes C, Lemos-Senna E, Assreuy J. Barp CG, et al. Nitric Oxide. 2018 Jun 1;76:129-135. doi: 10.1016/j.niox.2017.09.003. Epub 2017 Sep 21. Nitric Oxide. 2018. PMID: 28943472 Free article.
NOS-1-derived NO has been shown to be a relevant species in physiology but also is an important element in pathology. There exist some NOS-1 inhibitors and among of them, 7-nitroindazole has been used for its in vivo selectivity. However, 7-NI has a very short half- …
NOS-1-derived NO has been shown to be a relevant species in physiology but also is an important element in pathology. There exist some NOS-1 …
7-Nitroindazole enhances c-Fos expression in spinal neurons in rats realizing operant movements.
Man'kovskaya YP, Maisky VA, Vlasenko OV, Maznychenko AV. Man'kovskaya YP, et al. Acta Histochem. 2014 Oct;116(8):1427-33. doi: 10.1016/j.acthis.2014.09.006. Epub 2014 Oct 11. Acta Histochem. 2014. PMID: 25306252
Fos-immunoreactive neurons were visualized immunohistochemically in the C6/C7 spinal segments in the control, realized operant movements animals, and/or 7-nitroindazole (7-NI) injected rats. The mean numbers of immunoreactive interneurons and motoneurons (per sectio …
Fos-immunoreactive neurons were visualized immunohistochemically in the C6/C7 spinal segments in the control, realized operant movements ani …
1,457 results