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Page 1
Anti-diabetic and anti-oxidative effects of 4-hydroxypipecolic acid in C57BL/KsJ-db/db mice.
Singh AB, Khaliq T, Chaturvedi JP, Narender T, Srivastava AK. Singh AB, et al. Hum Exp Toxicol. 2012 Jan;31(1):57-65. doi: 10.1177/0960327111407227. Epub 2011 Jun 8. Hum Exp Toxicol. 2012. PMID: 21653626
In the present study, the authors determine anti-diabetic and anti-oxidative properties of 4-hydroxypipecolic acid (4-HPA) isolated from seeds of P. harmala in C57BL/KsJ-db/db mice. Twelve week old male mice were administered 50 mg/kg body weight (4-HPA suspe …
In the present study, the authors determine anti-diabetic and anti-oxidative properties of 4-hydroxypipecolic acid (4-H …
Glucose uptake stimulatory effect of 4-hydroxypipecolic acid by increased GLUT 4 translocation in skeletal muscle cells.
Naresh G, Jaiswal N, Sukanya P, Srivastava AK, Tamrakar AK, Narender T. Naresh G, et al. Bioorg Med Chem Lett. 2012 Sep 1;22(17):5648-51. doi: 10.1016/j.bmcl.2012.06.101. Epub 2012 Jul 11. Bioorg Med Chem Lett. 2012. PMID: 22840238
In continuation of our drug development program on Indian medicinal plants we discovered antihyperglycemic activity in 4-hydroxypipecolic acid (4-HPA), isolated from the seed of P. harmala. ...
In continuation of our drug development program on Indian medicinal plants we discovered antihyperglycemic activity in 4-hydroxypi …
An efficient synthesis of cis-4-hydroxyphosphonic and cis-4-hydroxyphosphinic analogs of pipecolic acid from cyclic enaminones.
Argüello-Velasco RO, Morales-Solís JC, Muñoz-Vidales M, Viveros-Ceballos JL, Romero-Estudillo I, Ordóñez M. Argüello-Velasco RO, et al. Amino Acids. 2022 Feb;54(2):299-310. doi: 10.1007/s00726-022-03124-w. Epub 2022 Jan 16. Amino Acids. 2022. PMID: 35037098
An expedient synthetic entry to cis-4-hydroxyphosphonic and cis-4-hydroxyphosphinic analogs of cis-4-hydroxypipecolic acid is presented in this paper. The main feature of this methodology is the highly regioselective addition of silyl phosphites or phosphonit …
An expedient synthetic entry to cis-4-hydroxyphosphonic and cis-4-hydroxyphosphinic analogs of cis-4-hydroxypipecolic acid …
Synthesis of novel enantiopure 4-hydroxypipecolic acid derivatives with a bicyclic beta-lactam structure from a common 3-azido-4-oxoazetidine-2-carbaldehyde precursor.
Alcaide B, Almendros P, Luna A, Martínez del Campo T. Alcaide B, et al. J Org Chem. 2008 Feb 15;73(4):1635-8. doi: 10.1021/jo702405h. Epub 2008 Jan 16. J Org Chem. 2008. PMID: 18197687
Two different stereocontrolled accesses to new 4-hydroxypipecolic acid analogues with a bicyclic beta-lactam structure have been developed by using intramolecular reductive amination or allenic hydroamination reactions in 2-azetidinone-tethered azides. ...
Two different stereocontrolled accesses to new 4-hydroxypipecolic acid analogues with a bicyclic beta-lactam structure …
Betaines and related ammonium compounds in chestnut (Castanea sativa Mill.).
Servillo L, Giovane A, Casale R, Balestrieri ML, Cautela D, Paolucci M, Siano F, Volpe MG, Castaldo D. Servillo L, et al. Food Chem. 2016 Apr 1;196:1301-9. doi: 10.1016/j.foodchem.2015.10.070. Epub 2015 Oct 17. Food Chem. 2016. PMID: 26593620
Interestingly, some uncommon derivatives of pipecolic acid, such as N-methylpipecolic acid, 4-hydroxypipecolic acid and 4-hydroxy-N-methylpipecolic acid were identified for the first time in chestnut samples and characterized by MS(n) tandem mass spectrometry …
Interestingly, some uncommon derivatives of pipecolic acid, such as N-methylpipecolic acid, 4-hydroxypipecolic acid and …
Non-protein amino acids of Bocoa (Leguminosae; Papilionoideae).
Kite GC, Ireland H. Kite GC, et al. Phytochemistry. 2002 Jan;59(2):163-8. doi: 10.1016/s0031-9422(01)00447-2. Phytochemistry. 2002. PMID: 11809451
Cowan was found to contain trans-5-hydroxypipecolic acid and trans-4-cis-5-dihydroxypipecolic acid, while trans-4-hydroxypipecolic acid and an unidentified compound were the major non-protein amino acids in B. prouacensis Aublet. ...
Cowan was found to contain trans-5-hydroxypipecolic acid and trans-4-cis-5-dihydroxypipecolic acid, while trans-4-hydroxypipecolic …
18 results