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Page 1
Sulfonate esters of 1-hydroxypyridin-2(1H)-one and ethyl 2-cyano-2-(hydroxyimino)acetate (oxyma) as effective peptide coupling reagents to replace 1-hydroxybenzotriazole and 1-hydroxy-7-azabenzotriazole.
Khattab SN. Khattab SN. Chem Pharm Bull (Tokyo). 2010 Apr;58(4):501-6. doi: 10.1248/cpb.58.501. Chem Pharm Bull (Tokyo). 2010. PMID: 20410632 Free article.
An improvement in yield and almost comparable optical purity to that of the 1-hydroxy-benzotriazole (HOBt) and 1-hydroxy-7-azabenzotriazole (HOAt) analogues was observed....
An improvement in yield and almost comparable optical purity to that of the 1-hydroxy-benzotriazole (HOBt) and 1-hydroxy-7 …
Reactions of monoaryl-substituted methylenecyclobutanes and methylenecyclopropanes with 1-hydroxybenzotriazole (HOBt), 1-hydroxy-7-azabenzotriazole (HOAt), and 1-hydroxysuccinimide (HOSu).
Jiang M, Shi M. Jiang M, et al. J Org Chem. 2009 Mar 20;74(6):2516-20. doi: 10.1021/jo9000299. J Org Chem. 2009. PMID: 19222218
Monoaryl-substituted methylenecyclobutanes (MCBs) and methylenecyclopropanes (MCPs) react with 1-hydroxybenzotriazole (HOBt), 1-hydroxy-7-azabenzotriazole (HOAt), and 1-hydroxysuccinimide (HOSu) smoothly to produce the corresponding cyclobutylmethanone …
Monoaryl-substituted methylenecyclobutanes (MCBs) and methylenecyclopropanes (MCPs) react with 1-hydroxybenzotriazole (HOBt), 1-hy …
A combination of experiment and theoretical methods to study the novel and low-cost corrosion inhibitor 1-hydroxy-7-azabenzotriazole for mild steel in 1 M sulfuric acid.
Gao L, Peng S, Gong Z, Chen J. Gao L, et al. RSC Adv. 2018 Nov 15;8(67):38506-38516. doi: 10.1039/c8ra06145a. eCollection 2018 Nov 14. RSC Adv. 2018. PMID: 35559084 Free PMC article.
1-Hydroxy-7-azabenzotriazole (HOAT) was explored via experimental and theoretical computation methods as a corrosion inhibitor for mild steel in 1 M sulfuric acid. ...
1-Hydroxy-7-azabenzotriazole (HOAT) was explored via experimental and theoretical computation methods as a corro …
Cyclization of all-L-Pentapeptides by Means of 1-Hydroxy-7-azabenzotriazole-Derived Uronium and Phosphonium Reagents.
Ehrlich A, Heyne HU, Winter R, Beyermann M, Haber H, Carpino LA, Bienert M. Ehrlich A, et al. J Org Chem. 1996 Dec 13;61(25):8831-8838. doi: 10.1021/jo951108d. J Org Chem. 1996. PMID: 11667862
For linear peptides that do not contain turn structure-inducing amino acid residues, the cyclization reaction may be an inherently improbable or slow process, and side reactions, such as cyclodimerization and epimerization at the C-terminal residue, may dominate. A number of 1 …
For linear peptides that do not contain turn structure-inducing amino acid residues, the cyclization reaction may be an inherently improbabl …
Blind crystal structure prediction of a novel second polymorph of 1-hydroxy-7-azabenzotriazole.
Nowell H, Frampton CS, Waite J, Price SL. Nowell H, et al. Acta Crystallogr B. 2006 Aug;62(Pt 4):642-50. doi: 10.1107/S0108768106012584. Epub 2006 Jul 12. Acta Crystallogr B. 2006. PMID: 16840814
The commercially available peptide coupling reagent 1-hydroxy-7-azabenzotriazole has been shown to crystallize in two polymorphic forms. ...
The commercially available peptide coupling reagent 1-hydroxy-7-azabenzotriazole has been shown to crystallize i …
Reactivity and applications of new amine reactive cross-linkers for mass spectrometric detection of protein-protein complexes.
Bich C, Maedler S, Chiesa K, DeGiacomo F, Bogliotti N, Zenobi R. Bich C, et al. Anal Chem. 2010 Jan 1;82(1):172-9. doi: 10.1021/ac901651r. Anal Chem. 2010. PMID: 19994840
New cross-linkers were synthesized by introducing N-hydroxyphthalimide, hydroxybenzotriazole, and 1-hydroxy-7-azabenzotriazole as leaving groups instead of the commonly used N-hydroxysuccimidyl moiety. ...Not only lysine but also tyrosine was found to …
New cross-linkers were synthesized by introducing N-hydroxyphthalimide, hydroxybenzotriazole, and 1-hydroxy-7-azaben …
Head-to-tail macrocyclization of cysteine-free peptides using an o-aminoanilide linker.
Ohara T, Kaneda M, Saito T, Fujii N, Ohno H, Oishi S. Ohara T, et al. Bioorg Med Chem Lett. 2018 May 1;28(8):1283-1286. doi: 10.1016/j.bmcl.2018.03.027. Epub 2018 Mar 14. Bioorg Med Chem Lett. 2018. PMID: 29580681
The subsequent cyclization smoothly proceeded by neutralization in the presence of additives such as 1-hydroxybenzotriazole (HOBt) and 1-hydroxy-7-azabenzotriazole (HOAt) to afford the expected cyclic pentapeptide, a CXCR4 antagonist. ...
The subsequent cyclization smoothly proceeded by neutralization in the presence of additives such as 1-hydroxybenzotriazole (HOBt) and 1 …
Oxyma-B, an excellent racemization suppressor for peptide synthesis.
Jad YE, Khattab SN, de la Torre BG, Govender T, Kruger HG, El-Faham A, Albericio F. Jad YE, et al. Org Biomol Chem. 2014 Nov 14;12(42):8379-85. doi: 10.1039/c4ob01612b. Org Biomol Chem. 2014. PMID: 25233797
Recently, ethyl 2-cyano-2-(hydroxyimino)acetate (OxymaPure) has emerged as a highly reactive alternative to the classic and explosion-prone benzotriazolic additives, namely 1-hydroxybenzotriazole (HOBt) and 1-hydroxy-7-azabenzotriazole (HOAt). Here we …
Recently, ethyl 2-cyano-2-(hydroxyimino)acetate (OxymaPure) has emerged as a highly reactive alternative to the classic and explosion-prone …
34 results