Human Down syndrome microglia are up for a synaptic feast

Ferdi Ridvan Kiral; In-Hyun Park

doi:10.1016/j.stem.2022.06.008

Human Down syndrome microglia are up for a synaptic feast

Cell Stem Cell. 2022 Jul 7;29(7):1007-1008. doi: 10.1016/j.stem.2022.06.008.

Authors

Ferdi Ridvan Kiral¹, In-Hyun Park²

Affiliations

¹ Department of Genetics, Yale Stem Cell Center, Yale School of Medicine, New Haven, CT 06520, USA.
² Department of Genetics, Yale Stem Cell Center, Yale School of Medicine, New Haven, CT 06520, USA. Electronic address: inhyun.park@yale.edu.

PMID: 35803219
DOI: 10.1016/j.stem.2022.06.008

Abstract

In this issue of Cell Stem Cell, Jin et al. report that human Down syndrome microglia exhibit enhanced synaptic engulfment and accelerated tau-induced cellular senescence in human-mouse chimeric brains. They show that inhibiting interferon signaling rescues both developmental and tau-associated phenotypes, rendering it a potential therapeutic target for Down syndrome.

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MeSH terms

Animals
Down Syndrome*
Humans
Mice
Microglia*