Cerebrospinal Fluid Iron-Ferritin Ratio as a Potential Progression Marker for Parkinson's Disease

Mov Disord. 2021 Dec;36(12):2967-2969. doi: 10.1002/mds.28790. Epub 2021 Sep 23.

Abstract

Longitudinal PD CSF samples were subjected to ICP-MS and the total amount of iron and other bioelements was quantified. Additionally, ferritin and protein biomarkers of neurodegeneration were measured. Over time, mean iron levels significantly increased while levels of ferritin decreased.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biomarkers / cerebrospinal fluid
  • Ferritins* / cerebrospinal fluid
  • Humans
  • Iron* / cerebrospinal fluid
  • Parkinson Disease* / cerebrospinal fluid
  • Parkinson Disease* / diagnosis

Substances

  • Biomarkers
  • Ferritins
  • Iron