Disseminated lymphangiomas as a cutaneous manifestation of Noonan syndrome

P Pérez-Feal; N Moreiras-Arias; C Buján-Bonino; J M Suárez-Peñaranda; V Fernández-Redondo

doi:10.1111/ced.14873

Disseminated lymphangiomas as a cutaneous manifestation of Noonan syndrome

Clin Exp Dermatol. 2022 Jan;47(1):180-182. doi: 10.1111/ced.14873. Epub 2021 Aug 30.

Authors

P Pérez-Feal¹, N Moreiras-Arias¹, C Buján-Bonino¹, J M Suárez-Peñaranda², V Fernández-Redondo¹

Affiliations

¹ Departments of Dermatology, Clinical University, Hospital of Santiago de Compostela, A Coruña, Spain.
² Departments of Pathology, Clinical University, Hospital of Santiago de Compostela, A Coruña, Spain.

PMID: 34363648
DOI: 10.1111/ced.14873

Abstract

Lymphangioma is a known, but rare manifestation of Noonan syndrome. We present the case of disseminated and circumscribed cutaneous lymphangiomas in the context of Noonan syndrome. Oral rapamycin is a promising treatment in these extensive and morbidity-causing cases.

Publication types

Case Reports
Letter

MeSH terms

Administration, Oral
Adolescent
Antibiotics, Antineoplastic / therapeutic use*
Humans
Lymphangioma / complications*
Lymphangioma / drug therapy*
Lymphangioma / pathology
Male
Noonan Syndrome / complications*
Penis / pathology
Scrotum / pathology
Sirolimus / therapeutic use*
Skin Neoplasms / complications*
Skin Neoplasms / drug therapy*
Skin Neoplasms / pathology
Treatment Outcome

Substances

Antibiotics, Antineoplastic
Sirolimus