Hippo signalling maintains ER expression and ER⁺ breast cancer growth

Nature. 2021 Mar;591(7848):E1-E10. doi: 10.1038/s41586-020-03131-5. Epub 2021 Mar 3.

Authors

Shenghong Ma^{1

2}, Zhengming Wu^{1

2}, Feng Yang³, Jianmin Zhang⁴, Randy L Johnson⁵, Michael G Rosenfeld³, Kun-Liang Guan^{6

7}

Affiliations

¹ Department of Pharmacology, University of California San Diego, La Jolla, CA, USA.
² Moores Cancer Center, University of California San Diego, La Jolla, CA, USA.
³ Howard Hughes Medical Institute, Department of Medicine, University of California San Diego, La Jolla, CA, USA.
⁴ Department of Cancer Genetics and Genomics, Roswell Park Cancer Institute, Buffalo, NY, USA.
⁵ Department of Cancer Biology, University of Texas, MD Anderson Cancer Center, Houston, TX, USA.
⁶ Department of Pharmacology, University of California San Diego, La Jolla, CA, USA. kuguan@ucsd.edu.
⁷ Moores Cancer Center, University of California San Diego, La Jolla, CA, USA. kuguan@ucsd.edu.

No abstract available

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Adaptor Proteins, Signal Transducing / metabolism
Amphiregulin / metabolism
Animals
Breast Neoplasms / metabolism*
Breast Neoplasms / pathology*
Cell Differentiation / genetics
Cell Lineage / genetics
Cells, Cultured
Estrogen Receptor alpha / metabolism*
Female
Hippo Signaling Pathway
Humans
MCF-7 Cells
Mice
Proteasome Endopeptidase Complex / metabolism
Protein Serine-Threonine Kinases / deficiency
Protein Serine-Threonine Kinases / metabolism*
Signal Transduction*
Trans-Activators / metabolism
Transcription Factors / metabolism
Transcriptional Coactivator with PDZ-Binding Motif Proteins
Tumor Suppressor Proteins / deficiency
Tumor Suppressor Proteins / metabolism*
Ubiquitin / metabolism
Ubiquitin-Protein Ligases / metabolism
YAP-Signaling Proteins

Substances

Adaptor Proteins, Signal Transducing
Amphiregulin
ESR1 protein, human
Estrogen Receptor alpha
Trans-Activators
Transcription Factors
Transcriptional Coactivator with PDZ-Binding Motif Proteins
Tumor Suppressor Proteins
Ubiquitin
WWTR1 protein, human
YAP-Signaling Proteins
YAP1 protein, human
Ubiquitin-Protein Ligases
LATS1 protein, human
LATS2 protein, human
DCAF1 protein, human
Protein Serine-Threonine Kinases
Proteasome Endopeptidase Complex

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