MYC and NOTCH1-positive postradiation cutaneous angiosarcoma of the breast

Breast J. 2021 Mar;27(3):264-267. doi: 10.1111/tbj.14171. Epub 2021 Feb 1.

Abstract

Postradiation cutaneous angiosarcoma of the breast is a rare, delayed complication of adjuvant radiation treatment for breast carcinoma and is associated with a worse prognosis than the original primary cancer. Recent studies have characterized the diagnostic utility of MYC and NOTCH1 receptor expression as markers for secondary radiation-associated angiosarcomas. Herein, we report an exophytic secondary breast angiosarcoma with MYC and NOTCH1 immunoreactivity. This case illustrates the utility of these markers for the identification of radiation-associated angiosarcoma with MYC and NOTCH1 expression, potential for targeted therapy and need to identify patients for further studies of the clinicopathologic and prognostic significance.

Keywords: MYC; NOTCH1; angiosarcoma; breast carcinoma.

MeSH terms

  • Breast
  • Breast Neoplasms* / radiotherapy
  • Female
  • Hemangiosarcoma* / etiology
  • Humans
  • Neoplasms, Radiation-Induced* / diagnosis
  • Neoplasms, Radiation-Induced* / etiology
  • Proto-Oncogene Proteins c-myc
  • Receptor, Notch1 / genetics

Substances

  • MYC protein, human
  • NOTCH1 protein, human
  • Proto-Oncogene Proteins c-myc
  • Receptor, Notch1

Supplementary concepts

  • Angiosarcoma of the breast