Solving the Puzzle of Immune Tolerance for β-Cell Replacement Therapy for Type 1 Diabetes

Cell Stem Cell. 2020 Oct 1;27(4):505-507. doi: 10.1016/j.stem.2020.09.008.

Abstract

Type 1 diabetes mellitus results from autoimmune destruction of pancreatic β cells. Insulin treatment is often inadequate in preventing devastating complications. Replacing β cells using stem cell-derived islets while fostering immune tolerance, exemplified in Yoshihara et al., holds the promise of a curative therapy for this disease.

Publication types

  • Comment

MeSH terms

  • Diabetes Mellitus, Type 1* / therapy
  • Humans
  • Immune Tolerance
  • Insulin-Secreting Cells*
  • Islets of Langerhans*
  • Organoids