An ischemic stroke as the presenting manifestation of rapidly progressive primary angiitis of central nervous system in a 17-year-old boy

J Neuroimmunol. 2020 Apr 15:341:577190. doi: 10.1016/j.jneuroim.2020.577190. Epub 2020 Feb 13.

Abstract

Background: Childhood primary angiitis of the central nervous system (cPACNS) is an increasingly recognized inflammatory brain disease in children.

Case presentation: We present a case of a 17-year-old boy with recurrent ischemic events over a short time period. Diagnosis of angiography positive cPACNS was made based on neuroimaging findings while secondary causes or mimics of CNS vasculitis were meticulously excluded. The patient exhibited rapid deterioration of his condition with poor initial response to immunosuppressive treatment.

Conclusions: Recognition of cPACNS remains a challenge because of rarity of disease, unexplained etiopathogenesis, protean clinical presentation, as well as lack of specific laboratory and neuroimaging markers.

Keywords: CNS vasculitis; Primary angiitis of the central cervous system; cPACNS.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Adrenal Cortex Hormones / therapeutic use
  • Age of Onset
  • Aphasia / etiology
  • Brain Ischemia / diagnostic imaging
  • Brain Ischemia / etiology*
  • Cerebral Angiography
  • Disease Progression
  • Humans
  • Immunoglobulins, Intravenous / therapeutic use
  • Immunosuppressive Agents / therapeutic use
  • Magnetic Resonance Imaging
  • Male
  • Neuroimaging
  • Paresis / etiology
  • Recurrence
  • Vasculitis, Central Nervous System / complications*
  • Vasculitis, Central Nervous System / diagnosis
  • Vasculitis, Central Nervous System / diagnostic imaging
  • Vasculitis, Central Nervous System / drug therapy

Substances

  • Adrenal Cortex Hormones
  • Immunoglobulins, Intravenous
  • Immunosuppressive Agents