Single Hepatitis B Booster Dose in High-risk Children with Suboptimal Surface Antigen Antibody Responses After 3-dose Primary Vaccine Series

Jia-Ming Low; Le-Ye Lee; Michelle Li Nien Tan; Michelle Hong; Si-Min Chan

Single Hepatitis B Booster Dose in High-risk Children with Suboptimal Surface Antigen Antibody Responses After 3-dose Primary Vaccine Series

Indian Pediatr. 2020 Jan 15;57(1):68-69.

Authors

Jia-Ming Low¹, Le-Ye Lee², Michelle Li Nien Tan³, Michelle Hong⁴, Si-Min Chan³

Affiliations

¹ Khoo Teck Puat-National University, Children's Medical Institute, Singapore. jia_ming_low@nuhs.edu.sg.
² Department of Paediatrics, Yong Loo Lin School of Medicine; National University of Singapore and Department of Neonatology, National University Hospital, Singapore.
³ Khoo Teck Puat-National University, Children's Medical Institute and Department of Paediatrics, Yong Loo Lin School of Medicine; National University of Singapore, Singapore.
⁴ Signature Research Program - Emerging Infectious Diseases, Duke-NUS Medical School, Singapore.

PMID: 31937704

Abstract

This was a descriptive study of 30 children born to HBsAG positive mothers between June 2009 and December 2013. All children had anti-HBs response ≤100 IU/L after 3 doses of hepatitis B vaccine primary series. A single booster dose led to hepatitis B surface antibody titers ≥100 IU/L in (85%) of children.

Publication types

Letter
Observational Study

MeSH terms

Child, Preschool
Female
Hepatitis B / prevention & control
Hepatitis B Antibodies / blood*
Hepatitis B Surface Antigens / immunology*
Hepatitis B Vaccines / immunology*
Humans
Immunization, Secondary*
Infant
Male

Substances

Hepatitis B Antibodies
Hepatitis B Surface Antigens
Hepatitis B Vaccines