Genetic Characterization of a Novel HIV-1 CRF07_BC/CRF55_01B Recombinant Form Identified in Jiangmen, China

AIDS Res Hum Retroviruses. 2020 Feb;36(2):134-137. doi: 10.1089/AID.2019.0141. Epub 2019 Oct 24.

Abstract

New recombinant variants are a predominant challenge for preventing the spread of the HIV-1 epidemic. In this study, we confirmed a novel HIV-1 CRF07_BC/CRF55_01B recombinant form for the first time, which was isolated from a male patient in Jiangmen, China. The genomic sequence of the variant with four CRF55_01B segments inserted into the CRF07_BC backbone is 8,510 bp in length, extending from nucleotides 669 to 9,293 according to the HXB2 genome. Specifically, the recombinant strain contains site mutations associated with drug resistance.

Keywords: CRF07_BC/CRF55_01B; HIV; mutation; recombinant.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • China
  • Drug Resistance, Viral / genetics
  • Genome, Viral*
  • Genotype
  • HIV Infections / virology*
  • HIV-1 / genetics*
  • HIV-1 / isolation & purification*
  • Humans
  • Male
  • Mutation
  • Phylogeny
  • RNA, Viral / genetics
  • Recombination, Genetic*
  • Sequence Analysis, DNA

Substances

  • RNA, Viral