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HIV DNA measurement and improved detection of HIV infection among MSM: a strategic implication.

Chen K, et al. AIDS Res Hum Retroviruses. 2019.


Rapid test (RT) is the principal screening method in the human immunodeficiency virus (HIV) control practice. However, this method may lead to inaccurate detection, primarily due to the more than 4 weeks' window phase. In the present study, we performed a HIV DNA screening method to show its application prospects in men who have sex with men (MSM). From July 2017 to April 2018, we recruited 1301 MSM from Beijing who were not previously diagnosed as HIV positive. Both HIV DNA detection and RT were performed. In total, 141 and 135 HIV positive results were detected by DNA detection and RT, respectively. By repetitive and confirmative tests (western blot), we verified that DNA detection detected 10 more true positives than RT and 4 false positives were corrected from RT. This represents 14 inaccurate RT results that were corrected by DNA measurement. Therefore, DNA measurement should be fully considered as a screening method in the detection of HIV among MSM in the future.


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