In vitro combination of voriconazole with micafungin against azole-resistant clinical isolates of Aspergillus fumigatus from different geographical regions

Hamed Fakhim; Afsane Vaezi; Eric Dannaoui; Cheshta Sharma; Bita Mousavi; Anuradha Chowdhary; Jacques F Meis; Hamid Badali

doi:10.1016/j.diagmicrobio.2018.03.003

In vitro combination of voriconazole with micafungin against azole-resistant clinical isolates of Aspergillus fumigatus from different geographical regions

Diagn Microbiol Infect Dis. 2018 Jul;91(3):266-268. doi: 10.1016/j.diagmicrobio.2018.03.003. Epub 2018 Mar 8.

Authors

Hamed Fakhim¹, Afsane Vaezi², Eric Dannaoui³, Cheshta Sharma⁴, Bita Mousavi⁵, Anuradha Chowdhary⁶, Jacques F Meis⁷, Hamid Badali⁸

Affiliations

¹ Department of Medical Parasitology and Mycology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran; Cellular and Molecular Research Center, Urmia University of Medical Sciences, Urmia, Iran. Electronic address: fakhiim.hamed@gmail.com.
² Department of Medical Mycology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran; Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran. Electronic address: vaeziiafsane@gmail.com.
³ Université Paris-Descartes, Faculté de Médecine, APHP, Hôpital Européen Georges Pompidou, Unité de Parasitologie-Mycologie, Service de Microbiologie, Paris, France. Electronic address: eric.dannaoui@aphp.fr.
⁴ Department of Medical Mycology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, India. Electronic address: cheshta03sharma@gmail.com.
⁵ Dynamyc Research Group (EA 7380), Paris Est Créteil University, Ecole nationale vétérinaire d'Alfort, Créteil, France. Electronic address: bimousavi@gmail.com.
⁶ Department of Medical Mycology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, India. Electronic address: chowdhary.anuradha@gmail.com.
⁷ Department of Medical Microbiology and Infectious Diseases, Canisius-Wilhelmina Hospital (CWZ), Nijmegen, The Netherlands; Center of Expertise in Mycology Radboudumc/CWZ, Nijmegen, The Netherlands. Electronic address: j.meis@cwz.nl.
⁸ Department of Medical Mycology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran; Pharmaceutical Sciences Research Center, Hemoglobinopathy Institute, Mazandaran University of Medical Sciences, Sari, Iran. Electronic address: badalii@yahoo.com.

PMID: 29622284
DOI: 10.1016/j.diagmicrobio.2018.03.003

Abstract

In vitro interaction of voriconazole with micafungin was evaluated against 33 clinical Aspergillus fumigatus isolates, including azole-resistant (n=31) and -susceptible (n=2) isolates. Interaction was synergistic for only 1 resistant isolate carrying the TR₃₄/L98H mutation. No antagonistic effects were observed for 96.8% of azole-resistant isolates.

Keywords: Aspergillus fumigatus; In vitro interactions; Micafungin; Voriconazole.

MeSH terms

Antifungal Agents / pharmacology*
Aspergillosis / microbiology*
Aspergillus fumigatus / drug effects*
Aspergillus fumigatus / isolation & purification
Drug Interactions*
Drug Resistance, Fungal
Echinocandins / pharmacology*
Humans
Lipopeptides / pharmacology*
Micafungin
Microbial Sensitivity Tests
Voriconazole / pharmacology*

Substances

Antifungal Agents
Echinocandins
Lipopeptides
Voriconazole
Micafungin