NLRP3 polymorphisms and response to interferon-beta in multiple sclerosis patients

Sunny Malhotra; Melissa Sorosina; Jordi Río; Silvia Peroni; Luciana Midaglia; Luisa M Villar; José C Álvarez-Cermeño; Ina Schroeder; Federica Esposito; Ferdinando Clarelli; Uwe K Zettl; Jeannette Lechner-Scott; Nino Spataro; Arcadi Navarro; Giancarlo Comi; Xavier Montalban; Filippo Martinelli-Boneschi; Manuel Comabella

doi:10.1177/1352458517739137

NLRP3 polymorphisms and response to interferon-beta in multiple sclerosis patients

Mult Scler. 2018 Oct;24(11):1507-1510. doi: 10.1177/1352458517739137. Epub 2017 Nov 9.

Authors

Sunny Malhotra¹, Melissa Sorosina², Jordi Río¹, Silvia Peroni², Luciana Midaglia¹, Luisa M Villar³, José C Álvarez-Cermeño³, Ina Schroeder⁴, Federica Esposito⁵, Ferdinando Clarelli², Uwe K Zettl⁴, Jeannette Lechner-Scott⁶, Nino Spataro⁷, Arcadi Navarro⁸, Giancarlo Comi⁹, Xavier Montalban¹, Filippo Martinelli-Boneschi¹⁰, Manuel Comabella¹

Affiliations

¹ Servei de Neurologia-Neuroimmunologia, Centre d'Esclerosi Múltiple de Catalunya (Cemcat) and Institut de Recerca Vall d'Hebron (VHIR), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.
² Laboratory of Human Genetics of Neurological Disorders, Institute of Experimental Neurology (INSPE), Division of Neuroscience, San Raffaele Scientific Institute, Milan, Italy.
³ Departments of Neurology and Immunology, Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigacion Sanitaria, Madrid, Spain.
⁴ Department of Neurology, Neuroimmunological Section, University of Rostock, Rostock, Germany.
⁵ Laboratory of Human Genetics of Neurological Disorders, Institute of Experimental Neurology (INSPE), Division of Neuroscience, San Raffaele Scientific Institute, Milan, Italy/Department of Neurology, Institute of Experimental Neurology (INSPE), Division of Neuroscience, San Raffaele Scientific Institute, Milan, Italy.
⁶ Department of Neurology, John Hunter Hospital, Newcastle, NSW, Australia/Hunter Medical Research Institute, The University of Newcastle, Newcastle, NSW, Australia.
⁷ Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain/Universitat Pompeu Fabra (UPF), Barcelona, Spain.
⁸ National Institute for Bioinformatics, Universitat Pompeu Fabra, Barcelona, Spain/Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain.
⁹ Department of Neurology, Institute of Experimental Neurology (INSPE), Division of Neuroscience, San Raffaele Scientific Institute, Milan, Italy.
¹⁰ Laboratory of Genetics of Complex Disorders and Department of Neurology, IRCCS Policlinico San Donato, Milan, Italy/Department of Biomedical Sciences for Health, University of Milan, Milan, Italy.

PMID: 29117789
DOI: 10.1177/1352458517739137

Abstract

We aimed to investigate whether NLR family, pyrin domain containing 3 (NLRP3) polymorphisms are associated with the response to interferon-beta (IFNβ) in multiple sclerosis (MS) patients. A total of 14 NLRP3 polymorphisms were genotyped in a cohort of 665 relapsing-remitting MS patients recruited across 5 centers and classified into responders and non-responders according to clinical-radiological criteria after 1 year of IFNβ treatment. A meta-analysis failed to demonstrate significant associations between the response to IFNβ and NLRP3 polymorphisms. These findings do not support a role of polymorphisms located in the NLRP3 gene and the response to IFNβ in MS patients.

Keywords: Multiple sclerosis; inflammasome; interferon-beta; polymorphisms.

Publication types

Multicenter Study
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Female
Genotype
Humans
Immunologic Factors* / therapeutic use
Interferon-beta* / therapeutic use
Male
Middle Aged
Multiple Sclerosis* / drug therapy
Multiple Sclerosis* / genetics
NLR Family, Pyrin Domain-Containing 3 Protein* / genetics
Polymorphism, Single Nucleotide

Substances

Immunologic Factors
Interferon-beta
NLR Family, Pyrin Domain-Containing 3 Protein
NLRP3 protein, human