Update on investigations pertaining to the pathogenesis of biliary atresia

Alexandra Kilgore; Cara L Mack

doi:10.1007/s00383-017-4172-6

Update on investigations pertaining to the pathogenesis of biliary atresia

Pediatr Surg Int. 2017 Dec;33(12):1233-1241. doi: 10.1007/s00383-017-4172-6. Epub 2017 Oct 24.

Authors

Alexandra Kilgore¹, Cara L Mack²

Affiliations

¹ Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, University of Colorado School of Medicine, Digestive Health Institute, Children's Hospital Colorado, Aurora, CO, 80045, USA.
² Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, University of Colorado School of Medicine, Digestive Health Institute, Children's Hospital Colorado, Aurora, CO, 80045, USA. cara.mack@childrenscolorado.org.

Abstract

Biliary atresia is a devastating biliary disease of neonates that results in liver transplantation for the vast majority. The etiology of biliary atresia is unknown and is likely multifactorial, with components of genetic predisposition, environmental trigger and autoimmunity contributing to disease pathogenesis. This review highlights recent work related to investigations of disease pathogenesis in biliary atresia.

Keywords: Autoimmunity; Genetic predisposition; Neonatal cholestasis.

Publication types

Review

MeSH terms

Autoimmunity*
Biliary Atresia* / epidemiology
Biliary Atresia* / genetics
Biliary Atresia* / immunology
Genetic Predisposition to Disease*
Global Health
Humans
Infant, Newborn
Morbidity

Abstract

Publication types

MeSH terms

Grants and funding