Genetic and pathogenic analysis of a novel reassortant H5N6 influenza virus isolated from waterfowl in South Korea in 2016

In Hong Lee; Seo Yeon Jin; Sang Heui Seo

doi:10.1007/s00705-017-3488-9

Genetic and pathogenic analysis of a novel reassortant H5N6 influenza virus isolated from waterfowl in South Korea in 2016

Arch Virol. 2017 Nov;162(11):3507-3510. doi: 10.1007/s00705-017-3488-9. Epub 2017 Jul 24.

Authors

In Hong Lee^{1

2}, Seo Yeon Jin^{1

2}, Sang Heui Seo^{3

4

5}

Affiliations

¹ Laboratory of Influenza Research, College of Veterinary Medicine, Chungnam National University, Daejeon, 34134, Republic of Korea.
² Institute for Influenza Virus, Chungnam National University, Daejeon, 34134, Republic of Korea.
³ Laboratory of Influenza Research, College of Veterinary Medicine, Chungnam National University, Daejeon, 34134, Republic of Korea. seos@cnu.ac.kr.
⁴ Institute for Influenza Virus, Chungnam National University, Daejeon, 34134, Republic of Korea. seos@cnu.ac.kr.
⁵ Laboratory of Influenza Research, College of Veterinary Medicine, Institute of Influenza Virus, Chungnam National University, 99 Dae-Hak Ro, Yuseong Gu, Daejeon, 305-764, Republic of Korea. seos@cnu.ac.kr.

PMID: 28736803
DOI: 10.1007/s00705-017-3488-9

Abstract

A novel reassortant highly pathogenic H5N6 influenza virus was isolated from waterfowl in South Korea in 2016. Seven genes of this virus originated from an H5N6 virus from China, whereas the remaining gene, PB1, was from an unknown virus. This virus productively infected pigs, which showed viral shedding through their noses and developed severe interstitial pneumonia.

Keywords: H5N6; Influenza virus; Pigs; Wild birds.

MeSH terms

Animals
Anseriformes*
Influenza A virus / genetics*
Influenza A virus / pathogenicity*
Influenza in Birds / epidemiology
Influenza in Birds / virology*
Reassortant Viruses
Republic of Korea / epidemiology