KIE: Legislation and regulation can make an important contribution to efforts to confront AIDS by promoting professional standards through reasoned guidelines; by mandating appropriate health care services and public education, particularly in sex education in schools, condom advertising, and outreach programs for drug-dependent people; by funding research; and by safeguarding confidentiality and protecting against discrimination. AIDS-related legislative and regulatory policy across the United States is reported and categorized, and an assessment is made of the likely impact of laws covering treatment and education, protection of the blood supply, screening, reporting, isolation, criminalization of HIV transmission, confidentiality, and discrimination.