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Increased risk of noninfluenza respiratory virus infections associated with receipt of inactivated influenza vaccine.

Randomized controlled trial
Cowling BJ, et al. Clin Infect Dis. 2012.

Abstract

We randomized 115 children to trivalent inactivated influenza vaccine (TIV) or placebo. Over the following 9 months, TIV recipients had an increased risk of virologically-confirmed non-influenza infections (relative risk: 4.40; 95% confidence interval: 1.31-14.8). Being protected against influenza, TIV recipients may lack temporary non-specific immunity that protected against other respiratory viruses.

PMID

22423139 [Indexed for MEDLINE]

PMCID

PMC3404712

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