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Regulation of bone mass by serotonin: molecular biology and therapeutic implications.

Review article
Karsenty G, et al. Annu Rev Med. 2011.


The molecular elucidation of two human skeletal dysplasias revealed that they are caused by an increase or a decrease in the synthesis of serotonin by enterochromaffin cells of the gut. This observation revealed a novel and powerful endocrine means to regulate bone mass. Exploiting these findings in the pharmacological arena led to the demonstration that inhibiting synthesis of gut-derived serotonin could be an effective means to treat low-bone-mass diseases such as osteoporosis.


21073335 [Indexed for MEDLINE]

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