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Impaired avidity maturation after tetanus toxoid booster in children with Down syndrome.

Kusters MA, et al. Pediatr Infect Dis J. 2011.


Down syndrome children show a decreased avidity of the antibody response after tetanus toxoid booster vaccination at 9 years of age suggesting impaired memory B cell selection in the germinal center. Clinicians need to be aware of this ongoing subtle immunologic deficit in Down syndrome.


21057373 [Indexed for MEDLINE]

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