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Benzoyl peroxide: a review of its current use in the treatment of acne vulgaris.

Review article
Sagransky M, et al. Expert Opin Pharmacother. 2009.


BACKGROUND: Owing to the use of topical and systemic antibiotics for acne vulgaris, the incidence of antibiotic-resistant Propionibacterium acnes is increasing worldwide. Topical benzoyl peroxide (BPO) is an alternative to antibiotics in the treatment of acne vulgaris.

OBJECTIVE: This review describes and evaluates recent clinical literature regarding the efficacy and tolerability of BPO.

METHODS: A PubMed literature search was conducted using the keywords benzoyl peroxide, acne, and combination therapy.

RESULTS: BPO is equally effective at concentrations of 2.5, 5.0 and 10%. However, a concentration-dependent irritant dermatitis can occur with higher concentrations. The efficacy of BPO can be enhanced when used in combination with topical retinoids, antibiotics and tertiary amines. BPO-containing combinations do not induce bacterial resistance and are important first-line treatments for mild to moderate acne vulgaris.


19761357 [PubMed - indexed for MEDLINE]

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