Background: Schizophrenia is associated with diverse white matter (WM) brain abnormalities. In this study, we sought to examine the WM microstructural findings which underlie clinical psychopathology clusters in schizophrenia and hypothesized that these symptom clusters are associated with common and unique WM tracts.
Methods: Overall, 76 healthy controls (HC), and 148 patients with schizophrenia (SZ) were recruited and severity of symptomatology in schizophrenia was assessed using the Positive and Negative Syndrome Scale. WM fractional anisotropy (FA) values were extracted from their diffusion tensor images. Psychopathology clusters were first determined using factor analysis and the relationship between these symptom factors and FA values were then assessed with structural equation modelling, which included covariates such as age, sex, duration of illness and medications prescribed.
Results: Patients with schizophrenia had reduced FA in the genu of corpus callosum (gCC) compared to HC. A three-factor model, namely Positive, Negative, Disorganised factors, was determined as the best fit for the data. All three psychopathology factors were associated with decreased FA in the gCC and bilateral cingulate gyrus. Higher Negative factor scores were uniquely associated with decreased FA in the right sagittal striatum and right superior longitudinal fasciculus.
Conclusions: This study found shared and specific WM changes and their associations with specific symptom clusters, which potentially allows for monitoring of such white matter findings associated with clinical presentations in schizophrenia over treatment and illness course.
Keywords: Diffusion tensor imaging; Dimensional psychopathology; Factor analysis; Neuroimaging; Structural equation modelling.
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Mean Kurtosis Alterations of Cerebral White Matter in Patients With Schizophrenia Revealed by Diffusion Kurtosis ImagingH Narita et al. Prog Neuropsychopharmacol Biol Psychiatry 71, 169-75. PMID 27495358.The diffusion kurtosis indices are suitable for evaluating altered WM structures in the human brain as they may detect white matter alterations of crossing fibers alterat …
The Paradoxical Relationship Between White Matter, Psychopathology and Cognition in Schizophrenia: A Diffusion Tensor and Proton Spectroscopic Imaging StudyA Caprihan et al. Neuropsychopharmacology 40 (9), 2248-57. PMID 25786581.White matter disruption has been repeatedly documented in schizophrenia consistent with microstructural disorganization (reduced fractional anisotropy (FA)) and axonal dy …
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- Corpus Callosum / pathology *
- Schizophrenia / pathology *
- Schizophrenia / physiopathology *
- White Matter / pathology *
- Corpus Callosum / diagnostic imaging
- Diffusion Tensor Imaging
- Schizophrenia / classification
- Schizophrenia / diagnostic imaging
- White Matter / diagnostic imaging
- Young Adult
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