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a{color:#333}.pmc-header__bar{max-width:1260px!important;margin-left:auto;margin-right:auto;padding-right:1.5rem;padding-left:1.5rem;display:flex;flex-direction:column;align-items:center;height:auto}@media screen and (min-width:600px){.pmc-header__bar{padding-right:3rem;padding-left:3rem}}@media screen and (min-width:951px){.pmc-header__bar{flex-direction:row}}.pmc-header__bar>*{width:100%}@media screen and (min-width:951px){.pmc-header__bar>*{width:unset}}.pmc-header__bar>:first-child{flex-grow:1}@media screen and (min-width:951px){.pmc-header__bar>:first-child{flex-grow:0}}@media screen and (min-width:951px)and (-ms-high-contrast:active),screen and (min-width:951px)and (-ms-high-contrast:none){.pmc-header__bar>:first-child{flex:0 20%}}.pmc-header__bar>:last-child{flex-grow:1}.pmc-header__control{display:flex;flex-direction:row;align-items:center}.pmc-header__search{display:flex;flex-direction:column;align-items:center}@media screen and 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(min-width:951px){.pmc-header--button{height:4.5rem;line-height:4.5rem}}.pmc-header--button[aria-expanded=false]{background:unset}.pmc-header--button:hover{background-color:unset;color:unset}.pmc-header--button:focus{box-shadow:unset!important}.pmc-header--button:active{background-color:unset}.pmc-page-banner{text-align:center}.pmc-page-banner>div{margin-bottom:3rem!important}.pmc-page-banner>div>img{display:block;margin-left:auto;margin-right:auto}.usa-nav-close{color:grey}.usa-nav-close>i{font-size:2rem}.usa-nav-close:hover{color:#000}@media screen and (max-width:951px){.usa-nav-secondary,.usa-nav-secondary-links{margin-top:2.5rem}}.usa-nav{width:100%!important}@media screen and (min-width:951px){.usa-nav>*{border-bottom:1px solid #d6d7d9}}.usa-nav-close{margin-bottom:0!important;width:4rem!important;height:4rem!important;position:absolute;right:4rem;top:2.2rem}.usa-nav-primary{margin-top:0}@media screen and (max-width:951px){.usa-nav-primary{margin-top:2.5rem}}@media screen and (max-width:951px){.usa-nav-primary button{padding-left:0!important}}@media screen and (min-width:951px){.usa-nav-primary button[aria-expanded=true],.usa-nav-primary button[aria-expanded=true]:hover{background-color:#20558a}.usa-nav-primary button[aria-expanded=true] span{border-bottom:.4rem solid #0071bc}}@media screen and (min-width:951px){.usa-nav-secondary{position:unset!important}}@media screen and (min-width:951px){.usa-megamenu:after,.usa-megamenu:before,.usa-nav-submenu,.usa-nav-submenu a:hover{background-color:#20558a}}.usa-nav-secondary-links li{display:inline}.usa-nav-secondary-links li:not(:nth-child(2)){padding-left:.5rem}.usa-nav-secondary-links li:not(:last-child):after{color:#d6d7d9;content:"|";padding-left:.5rem}@media screen and (max-width:951px){.js-search-button-container{display:none!important}}@media print{body>*{display:none}main[id=main-content]{display:block}}@media screen and (min-width:951px){.usa-width-three-fourths{float:left;display:block;margin-right:2.35765%;width:74.41059%}}@media screen and (min-width:951px){.usa-layout-docs{display:inherit}.usa-layout-docs-sidenav{padding-top:0}}@media screen and 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.fa-twitter{background-color:#00acee;color:#fff}.pmc-sidebar__share .fa-lg{font-size:1.1em}.pmc-sidebar__share .fa-facebook{background-color:#2f4788;color:#fff}.pmc-sidebar__share .share-permalink>.trigger{cursor:pointer;display:inline-block;padding:0;margin:0;background-color:transparent;border-radius:0}.pmc-sidebar__share .share-permalink>.trigger:focus{box-shadow:none;outline:2px dotted #aeb0b5;outline-offset:3px}.pmc-sidebar__share .share-permalink>.trigger .fa-link{background-color:#122e4f;color:#fff}.pmc-sidebar__share .share-permalink>.dropdown{right:auto;left:-12rem;margin-top:1.5rem;padding:1.2rem 1.6rem 1.6rem;z-index:1000}@media screen and (min-width:600px){.pmc-sidebar__share .share-permalink>.dropdown{right:0;left:auto}}@media screen and (min-width:600px)and (max-width:951px){.pmc-sidebar__share .share-permalink>.dropdown{margin-top:1.4rem;padding:1rem 1.2rem 1.2rem}}.pmc-sidebar__share .share-permalink>.dropdown:before{content:"";display:block;position:absolute;left:13rem;bottom:100%;width:1.2rem;height:1rem;background:url(data:image/svg+xml;base64,PHN2ZyB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciIHdpZHRoPSIxMCIgaGVpZ2h0PSIxMCI+PHBhdGggZmlsbD0iI2Q5ZDlkOSIgZD0iTTAgOWw1LTUgNSA1djFIMHoiLz48cGF0aCBmaWxsPSIjZmZmIiBkPSJNMCAxMGw1LTUgNSA1eiIvPjwvc3ZnPg==) no-repeat bottom/1.2rem}@media screen and (min-width:600px){.pmc-sidebar__share .share-permalink>.dropdown:before{right:.8rem;left:auto}}.pmc-sidebar__share .share-permalink>.dropdown.flipped{bottom:100%;top:auto}.pmc-sidebar__share .share-permalink>.dropdown.flipped:before{bottom:auto;top:100%;transform:rotate(180deg)}.pmc-sidebar__share .share-permalink>.dropdown>.title{font-weight:300;text-transform:lowercase;font-variant:small-caps;line-height:2rem;margin:0 0 1.3rem}@media screen and (min-width:600px)and (max-width:951px){.pmc-sidebar__share .share-permalink>.dropdown>.title{margin:0 0 1rem;text-align:left}}.pmc-sidebar__share .share-permalink>.dropdown>.content{white-space:nowrap}.pmc-sidebar__share .share-permalink>.dropdown .permalink-text{display:inline-block;width:200px;line-height:inherit;height:4.2rem;margin:0;padding:0 .7em}@media screen and (min-width:600px){.pmc-sidebar__share .share-permalink>.dropdown .permalink-text{width:300px;margin:.2em 0}}.pmc-sidebar__share .share-permalink>.dropdown .permalink-text::-ms-clear{display:none}.pmc-sidebar__share .share-permalink>.dropdown .permalink-copy-button{position:relative;display:inline-block;width:10rem;height:4.2rem;margin:0;border-bottom-left-radius:0;border-top-left-radius:0}.pmc-sidebar__share .share-permalink>.dropdown .permalink-copy-button>.button-title{padding-left:1.5rem}.pmc-sidebar__share .share-permalink>.dropdown .permalink-copy-button>.button-title:before{position:absolute;top:50%;-webkit-transform:translateY(-50%);transform:translateY(-50%);content:"";display:block;width:2rem;height:2rem;background:url(data:image/svg+xml;base64,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) no-repeat 50%/2rem;left:1rem}.pmc-sidebar__share i.fa{display:table-cell;text-align:center;vertical-align:middle;border-radius:50%}.pmc-sidebar__share i.fa:before{padding-left:5px}.pmc-sidebar__pubmed_links li{position:relative;display:block}.pmc-sidebar__pubmed_links li:not(:last-child){padding-bottom:10px}.pmc-sidebar__pubmed_links li:not(:last-child):after{content:"";width:60%;height:1px;background:#ccc;position:absolute;bottom:0;left:0}