Protective long-term antibody memory by antigen-driven and T
 help-dependent differentiation of long-lived memory B cells to
 short-lived plasma cells independent of secondary lymphoid organs

doi:10.1073/pnas.230417497

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Proc Natl Acad Sci U S A. 2000 Nov 21; 97(24): 13263–13268.

Published online 2000 Nov 7. doi: 10.1073/pnas.230417497

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Figure 1

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B cell and antibody memory after immunization with live virus vs. viral proteins. C57BL/6 mice were infected with 200 pfu of LCMV-WE (A) or 2 × 10⁶ pfu of VSV-IND (●) or –NJ (○) (C and E) i.v. or immunized with 10 or 1 μg of Baculo-derived LCMV-NP protein (B) or UV-inactivated VSV-IND (2 × 10⁸ pfu; D and F) and LCMV-NP binding (A and B), VSV-NP-binding (E and F) and VSV-IND-neutralizing (C and D) antibody titers were assessed. Results are shown as means ± SD of 3–4 mice per group. The experiment was repeated twice with similar results.

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