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NCBI Insights SEPT. 25, 2020

Primer-BLAST now designs primers for a group of related sequences

Primer-BLAST now has a “Primers common for a group of sequences” submission tab that allows you to design primers for a group of highly similar sequences. For example, you may want test for expression of any transcript of gene rather than a specific splice variant, so you want to design primers to cover all transcript …

NIH Director's Blog SEPT. 24, 2020

Insulin-Producing Organoids Offer Hope for Treating Type 1 Diabetes

For the 1 to 3 million Americans with type 1 diabetes, the immune system destroys insulin-producing beta cells of the pancreas that control the amount of glucose in the bloodstream. As a result, these individuals must monitor their blood glucose often and take replacement doses of insulin to keep it under control. Such constant attention, combined with a strict diet to control sugar intake, is challenging—especially for children.

Research news

The New York Times TODAY

Leader of India Says Country’s Vaccine Industry Will ‘Help All Humanity’

A study offered an explanation for children’s ability to fight off the virus. The lockdown in Melbourne, Australia, is being further eased.

The New York Times YESTERDAY

A Man Died After Eating a Bag of Black Licorice Every Day

Doctors at Massachusetts General Hospital said the unusual case highlighted the risk of consuming too much glycyrrhizic acid, which is found in black licorice.

NCBI databases

NCBI Virus

The most up-to-date set of SARS‑CoV‑2 nucleotide and protein sequences

LitCovid

A curated literature hub for the latest scientific information on COVID-19

BLAST

Use our new Betacoronavirus database for SARS‑CoV‑2 genome sequence analysis

Literature

The World's largest repository of medical and scientific abstracts, full-text articles, books and reports

Bookshelf

Books and reports

MeSH

Ontology used for PubMed indexing

NLM Catalog

Books, journals and more in the NLM Collections

PubMed

Scientific and medical abstracts/citations

PubMed Central

Full-text journal articles

Genes

Gene sequences and annotations used as references for the study of orthologs structure, expression, and evolution

Gene

Collected information about gene loci

GEO DataSets

Functional genomics studies

GEO Profiles

Gene expression and molecular abundance profiles

HomoloGene

Homologous genes sets for selected organisms

PopSet

Sequence sets from phylogenetic and population studies

Proteins

Protein sequences, 3-D structures, and tools for the study of functional protein domains and active sites

Conserved Domains

Conserved protein domains

Identical Protein Groups

Protein sequences grouped by identity

Protein

Protein sequences

Protein Clusters

Sequence similarity-based protein clusters

Sparcle

Functional categorization of proteins by domain architecture

Structure

Experimentally-determined biomolecular structures

Genomes

Genome sequence assemblies, large-scale functional genomics data, and source biological samples

Assembly

Genome assembly information

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BioProject

Biological projects providing data to NCBI

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Descriptions of biological source materials

Genome

Genome sequencing projects by organism

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DNA and RNA sequences

SRA

High-throughput sequence reads

Taxonomy

Taxonomic classification and nomenclature

BLAST

A tool to find regions of similarity between biological sequences

blastn

Search nucleotide sequence databases

blastp

Search protein seqeuence databases

blastx

Search protein databases using a translated nucleotide query

tblastn

Search translated nucleotide databases using a protein query

Primer-BLAST

Find primers specific to your PCR template

Genetics

Heritable DNA variations, associations with human pathologies, and clinical diagnostics and treatments

ClinVar

Human variations of clinical significance

dbGaP

Genotype/phenotype interaction studies

dbSNP

Short genetic variations

dbVar

Genome structural variation studies

GTR

Genetic testing registry

MedGen

Medical genetics literature and links

OMIM

Online mendelian inheritance in man

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Repository of chemical information, molecular pathways, and tools for bioactivity screening

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Bioactivity screening studies

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Chemical information with structures, information and links

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Molecular pathways with links to genes, proteins and chemicals

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