Caenorhabditis elegans gene ife-4, encoding translation Initiation Factor 4E eIF4E.
SUMMARY back to top
[Wormbase] The ife-4 gene encodes a member of the Initiation Factor 4E (eIF4E) family.
Wormbase predicts one model

AceView synopsis, each blue text links to tables and details
According to AceView, this gene is well expressed, 1.1 times the average gene in this release. The sequence of this gene is defined by 7 cDNA clones and 8 elements defined by RNA-seq.
The gene contains 3 distinct gt-ag introns. Transcription produces one mRNA. Variant a is transpliced to SL1.
Function: There are 4 articles specifically referring to this gene in PubMed. In addition we point below to 4 abstracts. Functionally, the gene has been proposed to participate in a process (translational initiation). Proteins are expected to have molecular functions (RNA binding activity, translation initiation factor activity) and to localize in cytoplasm.
The spliced mRNA putatively encodes a good protein, containing Eukaryotic translation initiation factor 4E (eIF-4E) domain [Pfam].

Please quote: AceView: a comprehensive cDNA-supported gene and transcripts annotation, Genome Biology 2006, 7(Suppl 1):S12.
Map on chromosome X, links to other databases and other names
Map: This gene ife-4 maps on chomosome X at position -18.76 (interpolated). In AceView, it covers 2.04 kb, from 1104210 to 1106249 (WS190), on the direct strand.
Links to: WormBase, RNAiDB.
Other names: The gene is also known in Wormgenes/AceView by its positional name XB723, in Wormbase by its cosmid.number name C05D9.5.
          Complete gene on genome diagram: back to top
Please choose between the zoomable GIF version., and the HTML5/SVG version.
This diagram shows in true scale the gene on the genome, the mRNAs and the cDNA clones.
Compact gene diagram back to top
Gene ife-4 5' 3' encoded on plus strand of chromosome X from 1,104,210 to 1,106,243 a 500bp 0 65 bp exon 65 bp exon 290 bp [gt-ag] intron 3 GenBank accessions 181 bp exon 482 bp [gt-ag] intron 3 GenBank accessions 238 bp exon 418 bp [gt-ag] intron 3 GenBank accessions 366 bp exon 15 accessions Transpliced 5' end, 1 accession Validated 3' end, 26 accessions 366 bp exon Alternative mRNAs are shown aligned from 5' to 3' on a virtual genome where introns have been shrunk to a minimal length. Exon size is proportional to length, intron height reflects the number of cDNAs supporting each intron, the small numbers show the support of the introns in deep sequencing (with details in mouse-over) . Introns of the same color are identical, of different colors are different. 'Good proteins' are pink, partial or not-good proteins are yellow, uORFs are green. 5' cap or3' poly A flags show completeness of the transcript.
Sequences: click on the numbers to get the DNA back to top
mRNA variant mRNA matching the genome Best predicted protein 3' UTR Upstream sequence Transcription
Downstream sequence
a 850 bp 212 aa 209 bp 2kb including Promoter 2040 bp 1kb

Gene neighbors and Navigator on chromosome X back to top
rme-6 D C I R P ife-4 C P lmp-2 C R XB733 C I P XB709 XB711 XB725 XB708 D C R P XB704 C XB714 C XB736 D C R P XB742 5kb 0 rme-6, 48 accessions, 3 variants ife-4, 15 accessions lmp-2, 47 accessions, 7 variants XB733, 20 accessions, 2 variants snx-1, 42 accessions, 5 variants XB709, 0 accession XB711, 0 accession XB723a, 0 accession XB725, 5 accessions XB708, 0 accession pfn-3, 12 accessions XB704, 22 accessions, 2 variants XB714, 16 accessions, 2 variants XB736, 22 accessions, 3 variants XB742, 10 accessions, 4 variants ZOOM OUT                 D:disease, C:conserved, I:interactions, R:regulation, P:publications         Read more...
Annotated mRNA diagrams back to top
Bibliography back to top
Please see these 4 articles in PubMed.
In addition we found 4 papers for which we do not have a PubMed identifier
? Gene Summary Gene on genome mRNA Expression Tissue Function, regulation, related genes C

To mine knowledge about the gene, please click the 'Gene Summary' or the 'Function, regulation, related genes ' tab at the top of the page. The 'Gene Summary' page includes all we learnt about the gene, functional annotations of neighboring genes, maps, links to other sites and the bibliography. The 'Function, regulation, related genes ' page includes Diseases (D), Pathways, GO annotations, conserved domains (C), interactions (I) reference into function, and pointers to all genes with the same functional annotation.
To see the mRNA diagram, sequence and annotation, click the 'mRNA' tab. To examine expression data from all cDNAs clustered in this gene by AceView, click the 'Expression tissue'.

If you know more about this gene, or found errors, please share your knowledge. Thank you !