Caenorhabditis elegans gene him-8, high Incidence of Males, encoding HIM-8 like family member.
SUMMARY back to top
[Wormbase] him-8 encodes a protein with two C-terminal noncanonical C2H2 zinc-fingers whose paralogs include ZIM-1/-3 and C02F5.12; HIM-8 is required by X chromosomes for normal homolog pairing, synapsis, recombination, and segregation during meiosis; him-8 mutants have an increased frequency of genotypically XO males in self-fertile hermaphrodite populations; HIM-8 is expressed during meiosis, and is associated with the X chromosome's meiotic pairing center (PC), which associates with the nuclear envelope during meiotic prophase; him-8 mutations are enhanced by rearrangements that inactivate the X-chromosomal PC; HIM-8 functions are genetically separable, since the him-8(me4) point mutation (which alters a domain N-terminal to HIM-8's zinc fingers) permits normal chromosome binding and nuclear localization, but causes abnormal pairing and synapsis; while the C-terminal region of HIM-8 most closely resembles those of its orthologs in other Caenorhabditis species, its N-terminal region is highly divergent, suggesting species-specific functions; unlike other him mutations, him-8 solely affects X chromosomes, and does not produce embryonic lethality via autosomal nondisjunction or aneuploidy; however, failure of X-chromosomal synapsis in him-8 mutants blocks the pachytene transistion from polarized to nonpolarized meiotic nuclei, by blocking the resolution of recombination intermediates on other chromosomes; him-8-blocked meiotic autosomes show persistent RAD-51 foci and have excess crossovers, both of which may be symptoms of a HUS-1-independent checkpoint induced by X-chromosomal nonsynapsis rather than DNA damage; HIM-8 also acts outside of meiosis, by inhibiting EGL-13 expression or activity; mutations of the HIM-8 zinc-finger domain semidominantly suppress missense (but not null) egl-13 mutations, due to him-8 haploinsufficiency; mutant HIM-8 fails to suppress mutant egl-13 on a free transgenic array, and also fails to suppress native mutant egl-13 if transgenic excess copies of the egl-13 promoter are present.
Map on chromosome IV, links to other databases and other names
Map: This gene him-8 maps on chomosome IV at position +4.85 (interpolated).
Links to: WormBase, RNAiDB.
Other names: The gene is also known in Wormgenes/AceView by its positional name 4L327, in Wormbase by its cosmid.number name T07G12.12.
          Complete gene on genome diagram: back to top
Please choose between the zoomable GIF version., and the HTML5/SVG version.
This diagram shows in true scale the gene on the genome, the mRNAs and the cDNA clones.
Compact gene diagram back to top
Gene him-8 5' 3' encoded on plus strand of chromosome IV from 10,561,877 to 10,563,946 0bp 0 Alternative mRNAs are shown aligned from 5' to 3' on a virtual genome where introns have been shrunk to a minimal length. Exon size is proportional to length, intron height reflects the number of cDNAs supporting each intron, the small numbers show the support of the introns in deep sequencing (with details in mouse-over) . Introns of the same color are identical, of different colors are different. 'Good proteins' are pink, partial or not-good proteins are yellow, uORFs are green. 5' cap or3' poly A flags show completeness of the transcript.
Sequences: click on the numbers to get the DNA back to top
Summaries of AceView transcripts and proteins back to top
Predicted protein properties back to top
Gene neighbors and Navigator on chromosome IV back to top
zim-1 C I R P zim-2 I P zim-3 D C I P him-8 D C P efn-2 D C I P lgc-43 C P C 4L315 4L319 C R 4L306 5kb 0 zim-1, 21 accessions, 4 variants zim-2, 22 accessions, 3 variants zim-3, 32 accessions, 5 variants him-8, 0 accession efn-2, 38 accessions, 2 variants lgc-43, 12 accessions 2 variants oac-8, 11 accessions 4L315, 0 accession 4L317, 2 accessions 4L319, 9 accessions, 4 variants 4L306, 15 accessions, 2 variants ZOOM OUT                 D:disease, C:conserved, I:interactions, R:regulation, P:publications         Read more...
Bibliography back to top
Please see these 10 articles in PubMed.
In addition we found 56 papers for which we do not have a PubMed identifier
? Gene Summary Gene on genome mRNA Expression Tissue Function, regulation, related genes DC

To mine knowledge about the gene, please click the 'Gene Summary' or the 'Function, regulation, related genes ' tab at the top of the page. The 'Gene Summary' page includes all we learnt about the gene, functional annotations of neighboring genes, maps, links to other sites and the bibliography. The 'Function, regulation, related genes ' page includes Diseases (D), Pathways, GO annotations, conserved domains (C), interactions (I) reference into function, and pointers to all genes with the same functional annotation.
To see the mRNA diagram, sequence and annotation, click the 'mRNA' tab. To examine expression data from all cDNAs clustered in this gene by AceView, click the 'Expression tissue'.

If you know more about this gene, or found errors, please share your knowledge. Thank you !