Caenorhabditis elegans gene her-1, HERmaphrodization of XO animals.
SUMMARY back to top
[Wormbase] her-1 generates two transcripts, the larger of which encodes a small, secreted, cysteine-rich protein (HER-1A) required for normal sex determination in wild-type XO male animals, while being dispensable for sex determination in XX hermaphrodites; transcription of her-1 in XX animals is repressed by SDC-2; HER-1A protein has two all-helical domains, with fourteen conserved cysteine residues forming seven disulfide bonds, at least eight of which residues are critical for function in vivo; HER-1A has no known homologs except in other nematodes (e.g., Brugia malayi), and does not structurally resemble other well-known secreted proteins; HER-1A inhibits the receptor TRA-2A in vivo, and binds it in vitro; HER-1A functions nonautonomously and requires a signal sequence for biological activity; the her-1(n695gf) mutation alters a site in the her-1 promoter bound by SDC-2, partially transforms XX animals into phenotypic males, and requires sup-26 and sup-27 to do so.
Wormbase predicts 2 models

AceView synopsis, each blue text links to tables and details
According to AceView, this gene is well expressed, 0.5 times the average gene in this release. The sequence of this gene is defined by 5 cDNA clones and one element defined by RNA-seq.
The gene contains 3 distinct gt-ag introns. Transcription produces one mRNA.
Function: There are 26 articles specifically referring to this gene in PubMed. In addition we point below to 107 abstracts. This gene is associated to a phenotype (HERmaphrodization of XO animals). The gene interacts with 12 other genes (DPY-21, DPY-30, FEM-3, FOX-1, SDC-1, SDC-2, SDC-3, SEL-10, TRA-1, TRA-2, TRA-3, XOL-1).
The spliced mRNA putatively encodes a good protein, some containing Protein of unknown function Her-1 domain [Pfam].

Please quote: AceView: a comprehensive cDNA-supported gene and transcripts annotation, Genome Biology 2006, 7(Suppl 1):S12.
Map on chromosome V, links to other databases and other names
Map: This gene her-1 maps on chomosome V at position +2.03 (interpolated). In AceView, it covers 4.90 kb, from 9697101 to 9701999 (WS190), on the direct strand.
Links to: WormBase, RNAiDB.
Other names: The gene is also known in Wormgenes/AceView by its positional name 5K181, in Wormbase by its cosmid.number name ZK287.8.
          Complete gene on genome diagram: back to top
Please choose between the zoomable GIF version., and the HTML5/SVG version.
This diagram shows in true scale the gene on the genome, the mRNAs and the cDNA clones.
Compact gene diagram back to top
Gene her-1 5' 3' encoded on plus strand of chromosome V from 9,697,101 to 9,701,879 a 500bp 0 143 bp exon 49 bp [gt-ag] intron 2 GenBank accessions 113 bp exon 3337 bp [gt-ag] intron 2 GenBank accessions 158 bp exon 509 bp [gt-ag] intron 6 GenBank accessions 590 bp exon 6 accessions 590 bp exon Alternative mRNAs are shown aligned from 5' to 3' on a virtual genome where introns have been shrunk to a minimal length. Exon size is proportional to length, intron height reflects the number of cDNAs supporting each intron, the small numbers show the support of the introns in deep sequencing (with details in mouse-over) . Introns of the same color are identical, of different colors are different. 'Good proteins' are pink, partial or not-good proteins are yellow, uORFs are green. 5' cap or3' poly A flags show completeness of the transcript.
Sequences: click on the numbers to get the DNA back to top
mRNA variant mRNA matching the genome Best predicted protein 3' UTR Upstream sequence Transcription
Downstream sequence
a 1004 bp 175 aa 476 bp 2kb 4899 bp 1kb

Gene neighbors and Navigator on chromosome V back to top
5K155 C 5K173 C her-1 D C I P xbx-6 D C I R P 5K195 C str-188 C 5K199 C 5K204 C 5K158 C I P ztf-9 D C R P rbx-1 C I R P 5K188 C 5K192 C 5K202 5kb 0 5K155, 36 accessions, 3 variants 5K173, 42 accessions, 4 variants her-1, 6 accessions xbx-6, 41 accessions, 5 variants 5K195, 21 accessions, 2 variants str-188, 0 accession 5K199, 4 accessions 5K182, 6 accessions 5K204, 0 accession 5K158, 22 accessions, 5 variants ztf-9, 351 accessions 5 variants rbx-1, 0 accession 5K188, 105 accessions 3 variants 5K192, 11 accessions 5K202, 28 accessions, 5 variants ZOOM OUT                 D:disease, C:conserved, I:interactions, R:regulation, P:publications         Read more...
Annotated mRNA diagrams back to top
Bibliography back to top
Please see these 26 articles in PubMed.
In addition we found 107 papers for which we do not have a PubMed identifier
? Gene Summary Gene on genome mRNA Expression Tissue Function, regulation, related genes DCI

To mine knowledge about the gene, please click the 'Gene Summary' or the 'Function, regulation, related genes ' tab at the top of the page. The 'Gene Summary' page includes all we learnt about the gene, functional annotations of neighboring genes, maps, links to other sites and the bibliography. The 'Function, regulation, related genes ' page includes Diseases (D), Pathways, GO annotations, conserved domains (C), interactions (I) reference into function, and pointers to all genes with the same functional annotation.
To see the mRNA diagram, sequence and annotation, click the 'mRNA' tab. To examine expression data from all cDNAs clustered in this gene by AceView, click the 'Expression tissue'.

If you know more about this gene, or found errors, please share your knowledge. Thank you !