Caenorhabditis elegans essential gene frh-1, encoding FRataxin Homolog, loss of function increases sensitivity to oxidative stress, impairs respiration, reduces lifespan, and causes lethality in a mitochondrial complex II mutant.
SUMMARY back to top
[Wormbase] frh-1 encodes the C. elegans frataxin ortholog; by homology, FRH-1 is predicted to be a mitochondrial protein required for biogenesis of iron-sulfur clusters, co-factors necessary for proper function of electron transport chain proteins; in C. elegans, loss of frh-1 activity via RNAi results in small body size, pale coloration, reduced egg-laying and fertility, altered responses to oxidative stress, and a significant lifespan extension.
Wormbase predicts one model

AceView synopsis, each blue text links to tables and details
According to AceView, this gene is well expressed, 0.8 times the average gene in this release. See the in situ hybridization pattern in Kohara NextDB. The sequence of this gene is defined by 7 cDNA clones and 4 elements defined by RNA-seq, some from l1 (seen once), l2 (once).
The gene contains 2 distinct gt-ag introns. Transcription produces one mRNA. Variant a is transpliced to SL5, SL9, SL2, SL1, SL3, SL4.
Function: There are 6 articles specifically referring to this gene in PubMed. In addition we point below to 2 abstracts. This essential gene is associated to a phenotype (embryonic lethal, partial, SLow growth, UNCoordinated locomotion, EGg Laying defective, EATing: abnormal pharyngeal pumping, abnormal oxidative stress response, shortens adult lifespan). Proteins are expected to localize in mitochondrion. This protein appears to interact with another protein (VAB-21). The gene interacts with MEV-1.
The spliced mRNA putatively encodes a good protein, containing Frataxin-like domain [Pfam].

Please quote: AceView: a comprehensive cDNA-supported gene and transcripts annotation, Genome Biology 2006, 7(Suppl 1):S12.
Map on chromosome II, links to other databases and other names
Map: This essential gene frh-1 maps on chomosome II at position -0.67 (interpolated). In AceView, it covers 1.14 kb, from 5917388 to 5918529 (WS190), on the direct strand.
Links to: WormBase, NextDB, RNAiDB.
Other names: The gene is also known in Wormgenes/AceView by its positional name 2G207, in Wormbase by its cosmid.number name F59G1.7, in NextDB, the Nematode expression pattern database, as CEYK9540.
Closest AceView homologs in other species ?
The closest human gene, according to BlastP, is the AceView gene FXN.
The closest mouse gene, according to BlastP, is the AceView gene Fxn (e=2 10-16).
The closest A.thaliana gene, according to BlastP, is the AceView gene ATFH\/FH
          Complete gene on genome diagram: back to top
Please choose between the zoomable GIF version., and the HTML5/SVG version.
This diagram shows in true scale the gene on the genome, the mRNAs and the cDNA clones.
Compact gene diagram back to top
Gene frh-1 5' 3' encoded on plus strand of chromosome II from 5,917,388 to 5,918,285 a 500bp 0 211 bp exon 46 bp [gt-ag] intron 8 GenBank accessions 97 bp exon 251 bp [gt-ag] intron 8 GenBank accessions 537 bp exon 11 accessions, some from l1 (seen once) l2 (once) Transpliced 5' end, 5 accessions Validated 3' end, 6 accessions 537 bp exon Alternative mRNAs are shown aligned from 5' to 3' on a virtual genome where introns have been shrunk to a minimal length. Exon size is proportional to length, intron height reflects the number of cDNAs supporting each intron, the small numbers show the support of the introns in deep sequencing (with details in mouse-over) . Introns of the same color are identical, of different colors are different. 'Good proteins' are pink, partial or not-good proteins are yellow, uORFs are green. 5' cap or3' poly A flags show completeness of the transcript.
Sequences: click on the numbers to get the DNA back to top
mRNA variant mRNA matching the genome Best predicted protein 3' UTR Upstream sequence Transcription
Downstream sequence
a 845 bp 136 aa 434 bp 2kb including Promoter 1142 bp 1kb

Gene neighbors and Navigator on chromosome II back to top
2G193 C lin-4 D I P tsp-18 D I P 2G197 R vps-35 D C R P cgt-3 C R frh-1 D C I P ptp-2 D C I R P vrk-1 D C I P egl-44 D C I R P 2G231 5kb 0 2G193, 32 accessions, 7 variants lin-4, 0 accession tsp-18, 0 accession 2G197, 12 accessions, 3 variants vps-35, 47 accessions 3 variants cgt-3, 112 accessions 11 variants frh-1, 11 accessions ptp-2, 51 accessions, 2 variants vrk-1, 141 accessions 4 variants egl-44, 102 accessions 8 variants 2G231, 7 accessions, 2 variants ZOOM OUT                 D:disease, C:conserved, I:interactions, R:regulation, P:publications         Read more...
Annotated mRNA diagrams back to top
Bibliography back to top
Please see these 6 articles in PubMed.
In addition we found 2 papers for which we do not have a PubMed identifier
? Gene Summary Gene on genome mRNA Expression Tissue Function, regulation, related genes DCI

To mine knowledge about the gene, please click the 'Gene Summary' or the 'Function, regulation, related genes ' tab at the top of the page. The 'Gene Summary' page includes all we learnt about the gene, functional annotations of neighboring genes, maps, links to other sites and the bibliography. The 'Function, regulation, related genes ' page includes Diseases (D), Pathways, GO annotations, conserved domains (C), interactions (I) reference into function, and pointers to all genes with the same functional annotation.
To see the mRNA diagram, sequence and annotation, click the 'mRNA' tab. To examine expression data from all cDNAs clustered in this gene by AceView, click the 'Expression tissue'.

If you know more about this gene, or found errors, please share your knowledge. Thank you !