Caenorhabditis elegans essential gene dpy-30, encoding nuclear protein required for dosage compensation and male development, DumPY : shorter than wild-type.
SUMMARY back to top
[Wormbase] The dpy-30 gene encodes an essential nuclear protein required for hermaphrodite dosage compensation as well as normal male development; DPY-30 is expressed ubiquitously throughout development and can be detected in two different multiprotein complexes: the SDC complex involved in dosage compensation and a second complex containing NOX-1 (a WD repeat-containing protein) and ASH-2 (a trithorax-related protein) that is homologous to the yeast Set1p complex involved in epigenetic regulation of transcription.
Wormbase predicts one model

AceView synopsis, each blue text links to tables and details
According to AceView, this gene is expressed at very high level, 5.0 times the average gene in this release, mostly in embryos, and some at all stages of development [Kohara cDNAs]. The expression profile for the gene, derived from the proportion of animals at each stage in each Kohara library is: embryos 60%, L1 or L2 larvae 16%, L3 to adult (including dauer) 23%. See the in situ hybridization pattern in Kohara NextDB. The sequence of this gene is defined by 44 cDNA clones and 22 elements defined by RNA-seq, some from embryo (seen 23 times), l1 (3), l2 (3), mixed (2), dauer (once), l4 (once). We annotate structural defects or features in 4 cDNA clones.
The gene contains 1 gt-ag intron. Transcription produces one mRNA. Variant a is transpliced to SL1.
Function: There are 11 articles specifically referring to this gene in PubMed. In addition we point below to 17 abstracts. This essential gene is associated to a phenotype (DumPY : shorter than wild-type, uncoordinated locomotion, sluggish, shared oogenic and spermatogenic protein copurified with chromatin). This protein appears to interact with other proteins (3G340, 4N366, 5F105, ASH-2, ZIM-1, ZIM-3). The gene interacts with 3 other genes (DPY-26, HER-1, XOL-1).
The spliced mRNA putatively encodes a good protein, containing Dpy-30, conserved site domain [Pfam].

Please quote: AceView: a comprehensive cDNA-supported gene and transcripts annotation, Genome Biology 2006, 7(Suppl 1):S12.
Map on chromosome V, links to other databases and other names
Map: This essential gene dpy-30 maps on chomosome V at position +3.85 (interpolated). In AceView, it covers 0.67 kb, from 12191496 to 12192161 (WS190), on the direct strand.
Links to: WormBase, NextDB, RNAiDB.
Other names: The gene is also known in Wormgenes/AceView by its positional name 5M671, in Wormbase by its cosmid.number name ZK863.6, in NextDB, the Nematode expression pattern database, as CEYK2336.
Closest AceView homologs in other species ?
The closest human gene, according to BlastP, is the AceView gene MEMO1.
The closest mouse gene, according to BlastP, is the AceView gene 2810410M20Rik
          Complete gene on genome diagram: back to top
Please choose between the zoomable GIF version., and the HTML5/SVG version.
This diagram shows in true scale the gene on the genome, the mRNAs and the cDNA clones.
Compact gene diagram back to top
Gene dpy-30 5' 3' encoded on plus strand of chromosome V from 12,191,496 to 12,192,161 a 100 200bp 0 52 bp exon 52 bp exon 79 bp [gt-ag] intron 42 GenBank accessions 530 bp exon 66 accessions, some from embryo (seen 23 times) l1 (3), l2 (3), mixed (2) dauer (once) Transpliced 5' end, 23 accessions Validated 3' end, 149 accessions 530 bp exon Alternative mRNAs are shown aligned from 5' to 3' on a virtual genome where introns have been shrunk to a minimal length. Exon size is proportional to length, intron height reflects the number of cDNAs supporting each intron, the small numbers show the support of the introns in deep sequencing (with details in mouse-over) . Introns of the same color are identical, of different colors are different. 'Good proteins' are pink, partial or not-good proteins are yellow, uORFs are green. 5' cap or3' poly A flags show completeness of the transcript.
Sequences: click on the numbers to get the DNA back to top
mRNA variant mRNA matching the genome Best predicted protein 5' UTR 3' UTR Upstream sequence Transcription
Downstream sequence
a 582 bp 123 aa 19 bp 191 bp 2kb including Promoter 661 bp 1kb

Gene neighbors and Navigator on chromosome V back to top
srd-4 C dpy-30 D C I P rnp-1 D C I R P 5M685 D C I R P C 5M648 C D C R elpc-3 C R P 5M662 C 5M668 C D C I P lon-3 5kb 0 srd-4, 2 accessions dpy-30, 66 accessions rnp-1, 27 accessions, 6 variants 5M685, 44 accessions, 5 variants vab-8, 127 accessions 4 variants col-37, 5 accessions, 2 variants 5M648, 9 accessions clec-224, 7 accessions elpc-3, 71 accessions 3 variants 5M662, 119 accessions 4 variants 5M668, 14 accessions 5M674, 3 accessions lon-3, 19 accessions ZOOM OUT                 D:disease, C:conserved, I:interactions, R:regulation, P:publications         Read more...
Annotated mRNA diagrams back to top
Bibliography back to top
Please see these 11 articles in PubMed.
In addition we found 17 papers for which we do not have a PubMed identifier
? Gene Summary Gene on genome mRNA Expression Tissue Function, regulation, related genes DCI

To mine knowledge about the gene, please click the 'Gene Summary' or the 'Function, regulation, related genes ' tab at the top of the page. The 'Gene Summary' page includes all we learnt about the gene, functional annotations of neighboring genes, maps, links to other sites and the bibliography. The 'Function, regulation, related genes ' page includes Diseases (D), Pathways, GO annotations, conserved domains (C), interactions (I) reference into function, and pointers to all genes with the same functional annotation.
To see the mRNA diagram, sequence and annotation, click the 'mRNA' tab. To examine expression data from all cDNAs clustered in this gene by AceView, click the 'Expression tissue'.

If you know more about this gene, or found errors, please share your knowledge. Thank you !