Summary
[Wormbase] dpy-26 encodes a novel, acidic protein that is highly conserved in other Caenorhabditis species; during development, dpy-26 activity is required for both dosage compensation and meiotic chromosome segregation; DPY-26 localizes to all meiotic chromosomes in the germline and to the hermaphrodite X chromosomes in somatic cells; SDC-1, SDC-2, and SDC-3 proteins form a complex and these three proteins, in turn, colocalize with DPY-26, DPY-27, and MIX-1 proteins both on the X chromosome and on a transgenic her-1(+) array.
Wormbase predicts one model.
AceView synopsis, each blue text links to tables and details
According to AceView, this gene is expressed at high level, 2.6 times the average gene in this release, at all stages of development [Kohara cDNAs]. The expression profile for the gene, derived from the proportion of animals at each stage in each Kohara library is: embryos 23%, L1 or L2 larvae 8%, L3 to adult 69%. See the in situ hybridization pattern in Kohara NextDB. The sequence of this gene is defined by 19 cDNA clones and 15 elements defined by RNA-seq, some from mixed (seen 7 times), embryo (6), l1 (once), l4 (once). We annotate structural defects or features in 2 cDNA clones.
The gene contains 9 distinct gt-ag introns. Transcription produces one mRNA. There are 3 validated alternative polyadenylation sites (see the diagram). Function: There are 10 articles specifically referring to this gene in PubMed. In addition we point below to 50 abstracts. This essential gene is associated to a phenotype (DumPY : shorter than wild-type, increased meiotic non disjunction, maternal effect daughterless, X chromosome dosage compensation defect, embryonic and early larval arrest, shared oogenic and spermatogenic protein copurified with chromatin). This protein appears to interact with other proteins (DPY-28, MIX-1). The gene interacts with 10 other genes (DPY-27, DPY-30, LIN-2, LIN-14, LIN-15A, LIN-15B, SDC-2, SDC-3, TRA-2, XOL-1).
The spliced mRNA putatively encodes a good protein, containing a vacuolar domain, a coiled coil stretch [Psort2].
Please quote: AceView: a comprehensive cDNA-supported gene and transcripts annotation, Genome Biology 2006, 7(Suppl 1):S12. Map on chromosome IV, links to other databases and other names Map: This essential gene dpy-26 maps on chomosome IV at position +6.68 (interpolated). In AceView, it covers 5.33 kb, from 12451266 to 12445935 (WS190), on the reverse strand. Links to:WormBase, NextDB, RNAiDB. Other names: The gene is also known in Wormgenes/AceView by its positional name 4N212, in Wormbase by its cosmid.number name C25G4.5, in NextDB, the Nematode expression pattern database, as CEYK136.
Please choose between the zoomable GIF version., and the HTML5/SVG version.
This diagram shows in true scale the gene on the genome, the mRNAs and the cDNA clones.
Alternative mRNAs are shown aligned from 5' to 3' on a virtual genome where introns have been shrunk to a minimal length. Exon size is proportional to length, intron height reflects the number of cDNAs supporting each intron, the small numbers show the support of the introns in deep sequencing (with details in mouse-over) . Introns of the same color are identical, of different colors are different. 'Good proteins' are pink, partial or not-good proteins are yellow, uORFs are green. 5' cap or3' poly A flags show completeness of the transcript. Read more...
Mouse over the ending of each transcript gives tissues from which the supporting cDNAs were extracted. Details on tissue of origin for each intron and exon is available from the intron and exons table.
Click on any transcript to open the specific mRNA page, to see the exact cDNA clone support and eventual SNPs and to get details on tissues, sequences, mRNA and protein annotations. Proteins supported by a single continuous cDNA sequence lead to underlining the name/ending of the variant. Names not underlined result from cDNA concatenation in the coding region and should be experimentally checked.
Introns are depicted by broken lines; the height of the top of each intron reflects the relative number of clones supporting this intron. ]^[ A pink broken line denotes an intron with standard boundaries (gt-ag or gc-ag) that is exactly supported (i.e. a cDNA sequence exactly matches the genome over 16 bp, 8 on both sides of the intron). ] ^ ] A blue broken line denotes non-standard introns, exactly supported, but with non-standard at-ac or any other boundaries. ]-[ Pink and ] - ] blue straight lines represent 'fuzzy' introns of the standard and non-standard types respectively, those introns do not follow the 16 bp rule. Black straight lines ]-[denote gaps in the alignments.
Exons: Wide filled pink areas represent putative protein coding regions, narrow empty pink boxes represent the 5'UTR (on the left) and 3' UTR (on the right). Flags identify validated endings: cap site on the 5' side, polyadenylation site on the 3' side. Filled flags correspond to frequent events while empty flags have lesser supporting cDNAs (yet all are validated); at the 3' side, black flags are associated to the main AATAAA signal, blue flags to any single letter variant of the main . More explanations are given in the gene help file
The mRNAs diagrams with the aligned cDNA sequence accessions and their mismatches are available in the mRNA pages accessible from the tab at the top of the page, or here:
In Flash: .a.
or in GIF: .a
Please see these 10 articles in PubMed.
In addition we found 50 papers for which we do not have a PubMed identifier
pm19123269
GB:U43562_2 Submitted (18-DEC-1995) Jason D. Lieb, Molecular and Cell Biology, University of California, Berkeley, 410 Barker Hall 3204, Berkeley, CA 94720-3204, USA
[wbg7.2p15] autosomal genes affected by X-chromosome dose.
[wbg11.3p52] dpy(y130): A New Maternal-Effect Gene Essential for the XX Mode of Dosage Compensation
[wbg11.2p118] dpy-29 and tra V mutations appear to define a single locus that coordinately regulates sex determination and dosage compensation.
[wbg12.1p31] Molecular analysis of the dosage compensation gene dpy-
[wm91p165] Genetic and Molecular Analysis of dpy(y130), a Gene Essential for the Hermapbrodite Mode of Dosage Compensation
[wm91p88] Effects of dosage compensation disruption on the regulation of sex determination.
[wm93p73] A molecular analysis of X chromosome function: the cloning of dpy-26.
[wbg13.1p60] Is Differential Histone H4 Acetylation Involved in the Mechanism of DosageCompensation?
[wbg13.2p43] Molecular Identification of a Major Feminizing Site on the X Chromosome: fox-1
[wbg13.3p38] Evidence For Interactions Between the Sex Determination and Dosage Compensation Pathways in the Germline
[wbg13.3p39] DPY-27: A Protein Required For Dosage Compensation is Associated With the X Chromosome in XX Animals
[wm95p54] A MOLECULAR MECHANISM FOR X CHROMOSOME DOSAGE COMPENSATION IN C. elegans
[wm95p163] CLONING THE DOSAGE COMPENSATION GENE dpy-21.
[wbg14.1p27] DPY-26 is a Novel Protein Associated with the X Chromosomes in XX Animals
[wcwm96p24] sdc-2 ACTS AS A SWITCH TO ACTIVATE DOSAGE COMPENSATION AND HERMAPHRODITE DIFFERENTIATION IN XX ANIMALS
[wcwm96p127] DPY-26 ACTS WITH DPY-27 AS A MEMBER OF A DOSAGE COMPENSATION COMPLEX AND INDEPENDENTLY IN MEIOTIC CHROMOSOME SEGREGATION
[wcwm96p25] A PROTEIN COMPLEX INCLUDING DPY-26, DPY-27 AND A MITOTIC CHROMOSOME CONDENSATION PROTEIN HOMOLOG IMPLEMENTS DOSAGE COMPENSATION IN C. ELEGANS
[wcwm96p93] Cloning the dosage compensation gene, dpy-21
[wcwm96p96] sdc-3 AND THE ASSEMBLY OF AN X CHROMOSOME DOSAGE COMPENSATION COMPLEX
[wm97ab99] Cloning the dosage compensation gene, dpy-21
[wm97e119] sdc-2 TRIGGERS HERMAPHRODITE-SPECIFIC DEVELOPMENT IN XX ANIMALS
[wm97e362] AN ESSENTIAL MITOTIC FACTOR IMPLEMENTS DOSAGE COMPENSATION DURING INTERPHASE
[wcwm98p62] dpy-28: AN ESSENTIAL DOSAGE COMPENSATION GENE ALSO REQUIRED FOR MEIOTIC CHROMOSOME SEGREGATION ENCODES A CHROMOSOME CONDENSATION HOMOLOG
[wcwm98p99] BIOCHEMICAL CHARACTERIZATION OF THE DOSAGE COMPENSATION COMPLEX TARGETED TO THE HERMAPHRODITE X CHROMOSOMES
[wcwm98p63] PROPERTIES OF X-CHROMOSOME RECOGNITION BY THE DOSAGE COMPENSATION MACHINERY
[wcwm98p220] Searching for new genes involved in dosage compensation
[wm99p229] Immunoaffinity purification of the C. elegans dosage compensation complex
[wm99p855] Searching for new genes involved in dosage compensation
[wcwm2000p82] Recognition and Assembly of SDC Protein Complexes onto Specific DNA Target Sites
[wcwm2000p238] Searching for new genes involved in dosage compensation
[wm2001p742] Genetic Analysis of Cell Cycle Control in the Germ Line
To mine knowledge about the gene, please click the 'Gene Summary' or the 'Function, regulation, related genes ' tab at the top of the page. The 'Gene Summary' page includes all we learnt about the gene, functional annotations of neighboring genes, maps, links to other sites and the bibliography. The 'Function, regulation, related genes ' page includes Diseases (D), Pathways, GO annotations, conserved domains (C), interactions (I) reference into function, and pointers to all genes with the same functional annotation.
To see the mRNA diagram, sequence and annotation, click the 'mRNA' tab. To examine expression data from all cDNAs clustered in this gene by AceView, click the 'Expression tissue'.
If you know more about this gene, or found errors, please share your knowledge. Thank you !
