[Wormbase] dpy-26 encodes a novel, acidic protein that is highly conserved in other Caenorhabditis species; during development, dpy-26 activity is required for both dosage compensation and meiotic chromosome segregation; DPY-26 localizes to all meiotic chromosomes in the germline and to the hermaphrodite X chromosomes in somatic cells; SDC-1, SDC-2, and SDC-3 proteins form a complex and these three proteins, in turn, colocalize with DPY-26, DPY-27, and MIX-1 proteins both on the X chromosome and on a transgenic her-1(+) array.
Wormbase predicts one model
AceView synopsis, each blue text links to tables and details
According to AceView, this gene is expressed at high level
, 2.6 times the average gene in this release, at all stages of development [Kohara cDNAs]. The expression profile for the gene, derived from the proportion of animals at each stage in each Kohara library is: embryos 23%, L1 or L2 larvae 8%, L3 to adult 69%. See the in situ hybridization pattern in Kohara NextDB
. The sequence
of this gene is defined by 19 cDNA clones
and 15 elements defined by RNA-seq, some from mixed (seen 7 times), embryo (6), l1 (once), l4 (once). We annotate structural defects or features
in 2 cDNA clones.
The gene contains 9 distinct gt-ag introns
. Transcription produces one mRNA. There are 3 validated alternative polyadenylation sites
(see the diagram
There are 10 articles
specifically referring to this gene in PubMed. In addition we point below
to 50 abstracts. This essential gene is associated to a phenotype
(DumPY : shorter than wild-type, increased meiotic non disjunction, maternal effect daughterless, X chromosome dosage compensation defect, embryonic and early larval arrest, shared oogenic and spermatogenic protein copurified with chromatin). This protein appears to interact
with other proteins (DPY-28, MIX-1). The gene interacts
with 10 other genes (DPY-27, DPY-30, LIN-2, LIN-14, LIN-15A, LIN-15B, SDC-2, SDC-3, TRA-2, XOL-1).
The spliced mRNA putatively encodes a good protein
, containing a vacuolar domain, a coiled coil stretch [Psort2]
Please quote: AceView: a comprehensive cDNA-supported gene and transcripts annotation, Genome Biology 2006, 7(Suppl 1):S12
Map on chromosome IV, links to other databases and other names
This essential gene dpy-26 maps on chomosome IV at position +6.68 (interpolated). In AceView, it covers 5.33 kb
, from 12451266 to 12445935 (WS190), on the reverse strand.
Links to: WormBase
The gene is also known in Wormgenes/AceView by its positional name 4N212, in Wormbase by its cosmid.number name C25G4.5, in NextDB, the Nematode expression pattern database, as CEYK136.
Alternative mRNAs are shown aligned from 5' to 3' on a virtual genome where introns have been shrunk to a minimal length. Exon size is proportional to length, intron height reflects the number of cDNAs supporting each intron, the small numbers show the support of the introns in deep sequencing (with details in mouse-over) . Introns of the same color are identical, of different colors are different. 'Good proteins' are pink, partial or not-good proteins are yellow, uORFs are green. 5' cap or3' poly A flags show completeness of the transcript.
Mouse over the ending of each transcript gives tissues from which the supporting cDNAs were extracted. Details on tissue of origin for each intron and exon is available from the intron and exons table
Click on any transcript to open the specific mRNA page, to see the exact cDNA clone support and eventual SNPs and to get details on tissues, sequences, mRNA and protein annotations. Proteins supported by a single continuous cDNA sequence lead to underlining the name/ending of the variant. Names not underlined result from cDNA concatenation in the coding region and should be experimentally checked.
are depicted by broken lines; the height of the top of each intron reflects the relative number of clones supporting this intron. ]^[ A pink broken line
denotes an intron with standard boundaries (gt-ag or gc-ag) that is exactly supported (i.e. a cDNA sequence exactly matches the genome over 16 bp, 8 on both sides of the intron). ] ^ ] A blue broken line
denotes non-standard introns, exactly supported, but with non-standard at-ac or any other boundaries. ]-[ Pink
and ] - ] blue
straight lines represent 'fuzzy' introns of the standard and non-standard types respectively, those introns do not follow the 16 bp rule. Black straight lines ]-[denote gaps in the alignments.
Wide filled pink areas represent putative protein coding regions, narrow empty pink boxes represent the 5'UTR (on the left) and 3' UTR (on the right). Flags identify validated endings: cap site on the 5' side, polyadenylation site on the 3' side. Filled flags correspond to frequent events while empty flags have lesser supporting cDNAs (yet all are validated); at the 3' side, black flags are associated to the main AATAAA signal, blue flags
to any single letter variant of the main . More explanations are given in the gene help file