Caenorhabditis elegans essential gene dpy-26, encoding X chromosome dosage compensation and meiotic chromosome segregation protein, DumPY : shorter than wild-type.
SUMMARY back to top
[Wormbase] dpy-26 encodes a novel, acidic protein that is highly conserved in other Caenorhabditis species; during development, dpy-26 activity is required for both dosage compensation and meiotic chromosome segregation; DPY-26 localizes to all meiotic chromosomes in the germline and to the hermaphrodite X chromosomes in somatic cells; SDC-1, SDC-2, and SDC-3 proteins form a complex and these three proteins, in turn, colocalize with DPY-26, DPY-27, and MIX-1 proteins both on the X chromosome and on a transgenic her-1(+) array.
Wormbase predicts one model

AceView synopsis, each blue text links to tables and details
According to AceView, this gene is expressed at high level, 2.6 times the average gene in this release, at all stages of development [Kohara cDNAs]. The expression profile for the gene, derived from the proportion of animals at each stage in each Kohara library is: embryos 23%, L1 or L2 larvae 8%, L3 to adult 69%. See the in situ hybridization pattern in Kohara NextDB. The sequence of this gene is defined by 19 cDNA clones and 15 elements defined by RNA-seq, some from mixed (seen 7 times), embryo (6), l1 (once), l4 (once). We annotate structural defects or features in 2 cDNA clones.
The gene contains 9 distinct gt-ag introns. Transcription produces one mRNA. There are 3 validated alternative polyadenylation sites (see the diagram).
Function: There are 10 articles specifically referring to this gene in PubMed. In addition we point below to 50 abstracts. This essential gene is associated to a phenotype (DumPY : shorter than wild-type, increased meiotic non disjunction, maternal effect daughterless, X chromosome dosage compensation defect, embryonic and early larval arrest, shared oogenic and spermatogenic protein copurified with chromatin). This protein appears to interact with other proteins (DPY-28, MIX-1). The gene interacts with 10 other genes (DPY-27, DPY-30, LIN-2, LIN-14, LIN-15A, LIN-15B, SDC-2, SDC-3, TRA-2, XOL-1).
The spliced mRNA putatively encodes a good protein, containing a vacuolar domain, a coiled coil stretch [Psort2].

Please quote: AceView: a comprehensive cDNA-supported gene and transcripts annotation, Genome Biology 2006, 7(Suppl 1):S12.
Map on chromosome IV, links to other databases and other names
Map: This essential gene dpy-26 maps on chomosome IV at position +6.68 (interpolated). In AceView, it covers 5.33 kb, from 12451266 to 12445935 (WS190), on the reverse strand.
Links to: WormBase, NextDB, RNAiDB.
Other names: The gene is also known in Wormgenes/AceView by its positional name 4N212, in Wormbase by its cosmid.number name C25G4.5, in NextDB, the Nematode expression pattern database, as CEYK136.
          Complete gene on genome diagram: back to top
Please choose between the zoomable GIF version., and the HTML5/SVG version.
This diagram shows in true scale the gene on the genome, the mRNAs and the cDNA clones.
Compact gene diagram back to top
Gene dpy-26 5' 3' encoded on minus strand of chromosome IV from 12,451,266 to 12,445,935 a 1 2kb 0 48 bp exon 48 bp exon 49 bp [gt-ag] intron 5 GenBank accessions 343 bp exon 55 bp [gt-ag] intron 6 GenBank accessions 980 bp exon 53 bp [gt-ag] intron 5 GenBank accessions 722 bp exon 458 bp [gt-ag] intron 4 GenBank accessions 618 bp exon 45 bp [gt-ag] intron 3 GenBank accessions 94 bp exon 488 bp [gt-ag] intron 3 GenBank accessions 69 bp exon 49 bp [gt-ag] intron 4 GenBank accessions 105 bp exon 48 bp [gt-ag] intron 7 GenBank accessions 516 bp exon 52 bp [gt-ag] intron 14 GenBank accessions 540 bp exon 34 accessions, some from mixed (seen 7 times) embryo (6), l1 (once) l4 (once) Validated 3' end, 7 accessions Validated 3' end, 21 accessions Validated 3' end, 2 accessions 540 bp exon Alternative mRNAs are shown aligned from 5' to 3' on a virtual genome where introns have been shrunk to a minimal length. Exon size is proportional to length, intron height reflects the number of cDNAs supporting each intron, the small numbers show the support of the introns in deep sequencing (with details in mouse-over) . Introns of the same color are identical, of different colors are different. 'Good proteins' are pink, partial or not-good proteins are yellow, uORFs are green. 5' cap or3' poly A flags show completeness of the transcript.
Sequences: click on the numbers to get the DNA back to top
mRNA variant mRNA matching the genome Best predicted protein 5' UTR 3' UTR Upstream sequence Transcription
Downstream sequence
a 4035 bp 1263 aa 6 bp 237 bp 2kb probably including promoter 5332 bp 1kb

Gene neighbors and Navigator on chromosome IV back to top
ugt-65 C R P C 4N201 D C I R P clec-185 C 4N221 D C P 4N223 C R P 4N233 C C P col-130 C 4N208 C 4N210 D C I R P dpy-26 C I R P 4N218 C 4N224 5kb 0 ugt-65, 17 accessions 5 variants clec-184, 14 accessions 4N201, 109 accessions clec-185, 7 accessions 4N221, 75 accessions 4N223, 11 accessions, 4 variants 4N233, 0 accession 4N235, 44 accessions, 3 variants 4N203, 4 accessions col-130, 12 accessions 4N208, 45 accessions 4N210, 5 accessions, 2 variants dpy-26, 34 accessions 4N218, 72 accessions 4N224, 8 accessions ZOOM OUT                 D:disease, C:conserved, I:interactions, R:regulation, P:publications         Read more...
Annotated mRNA diagrams back to top
Bibliography back to top
Please see these 10 articles in PubMed.
In addition we found 50 papers for which we do not have a PubMed identifier
? Gene Summary Gene on genome mRNA Expression Tissue Function, regulation, related genes DCI

To mine knowledge about the gene, please click the 'Gene Summary' or the 'Function, regulation, related genes ' tab at the top of the page. The 'Gene Summary' page includes all we learnt about the gene, functional annotations of neighboring genes, maps, links to other sites and the bibliography. The 'Function, regulation, related genes ' page includes Diseases (D), Pathways, GO annotations, conserved domains (C), interactions (I) reference into function, and pointers to all genes with the same functional annotation.
To see the mRNA diagram, sequence and annotation, click the 'mRNA' tab. To examine expression data from all cDNAs clustered in this gene by AceView, click the 'Expression tissue'.

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