Caenorhabditis elegans gene dhs-22, encoding DeHydrogenase, Short chain.
SUMMARY back to top
[Wormbase] dhs-22 encodes a short-chain dehydrogenase predicted to be mitochondrial.
Wormbase predicts one model

AceView synopsis, each blue text links to tables and details
According to AceView, this gene is expressed at high level, 4.0 times the average gene in this release, at all stages of development [Kohara cDNAs]. The expression profile for the gene, derived from the proportion of animals at each stage in each Kohara library is: embryos 16%, L1 or L2 larvae 45%, L3 to adult (including dauer) 39%. See the in situ hybridization pattern in Kohara NextDB. The sequence of this gene is defined by 21 cDNA clones and 31 elements defined by RNA-seq, some from l1 (seen 3 times), l2 (3), embryo (2), mixed (2). We annotate structural defects or features in 25 cDNA clones.
The gene contains 3 distinct gt-ag introns. Transcription produces one mRNA. Variant a is transpliced to SL2, SL5, SL9, SL1, SL3, SL4, SL7. 573 bp of this gene are antisense to spliced gene set-31, raising the possibility of regulated alternate expression.
Function: There is one article specifically referring to this gene in PubMed. Functionally, the gene has been proposed to participate in a process (metabolism). Proteins are expected to have molecular function (oxidoreductase activity).
The spliced mRNA putatively encodes a good protein, containing short-chain dehydrogenase/reductase SDR domain [Pfam].

Please quote: AceView: a comprehensive cDNA-supported gene and transcripts annotation, Genome Biology 2006, 7(Suppl 1):S12.
Map on chromosome V, links to other databases and other names
Map: This gene dhs-22 maps on chomosome V at position +6.23 (interpolated). In AceView, it covers 1.62 kb, from 14421418 to 14419801 (WS190), on the reverse strand.
Links to: WormBase, NextDB, RNAiDB.
Other names: The gene is also known in Wormgenes/AceView by its positional name 5O900, in Wormbase by its cosmid.number name C15H11.4, in NextDB, the Nematode expression pattern database, as CEYK3514.
Closest AceView homologs in other species ?
The closest human genes, according to BlastP, are the AceView genes RDH12, NT5C1BandRDH14, RDH13, DHRS13.
The closest mouse genes, according to BlastP, are the AceView genes Rdh12 (e=6 10-41), Rdh14 (e=7 10-41), Rdh13 (e=10-37), Dhrs13andFlot2 (e=8 10-37), Rdh11 (e=4 10-36).
The closest A.thaliana genes, according to BlastP, are the AceView genes AT4G23430, AT2G37540, AT4G23420
          Complete gene on genome diagram: back to top
Please choose between the zoomable GIF version., and the HTML5/SVG version.
This diagram shows in true scale the gene on the genome, the mRNAs and the cDNA clones.
Compact gene diagram back to top
Gene dhs-22 5' 3' encoded on minus strand of chromosome V from 14,421,418 to 14,420,040 a 1kb 0 102 bp exon 102 bp exon 48 bp [gt-ag] intron 10 GenBank accessions 127 bp exon 123 bp [gt-ag] intron 13 GenBank accessions 590 bp exon 55 bp [gt-ag] intron 13 GenBank accessions 573 bp exon 52 accessions, some from l1 (seen 3 times) l2 (3), embryo (2), mixed (2) Transpliced 5' end, 6 accessions Validated 3' end, 182 accessions 573 bp exon Alternative mRNAs are shown aligned from 5' to 3' on a virtual genome where introns have been shrunk to a minimal length. Exon size is proportional to length, intron height reflects the number of cDNAs supporting each intron, the small numbers show the support of the introns in deep sequencing (with details in mouse-over) . Introns of the same color are identical, of different colors are different. 'Good proteins' are pink, partial or not-good proteins are yellow, uORFs are green. 5' cap or3' poly A flags show completeness of the transcript.
Sequences: click on the numbers to get the DNA back to top
mRNA variant mRNA matching the genome Best predicted protein 5' UTR 3' UTR Upstream sequence Transcription
Downstream sequence
a 1392 bp 333 aa 13 bp 377 bp 2kb including Promoter 1618 bp 1kb

Gene neighbors and Navigator on chromosome V back to top
gnrr-2 C R C R set-31 C R P 5O909 C P 5O923 C I R P sru-43 D C P nxf-1 D C I R P nxf-2 C R P dhs-22 D C I R P pas-1 D C P 5O904 D C I R P rrbs-1 D C I P egl-1 5kb 0 gnrr-2, 8 accessions, 2 variants 5O895, 12 accessions set-31, 20 accessions 3 variants 5O909, 7 accessions 5O923, 118 accessions 9 variants 5O888, 6 accessions, 3 variants sru-43, 0 accession nxf-1, 13 accessions, 3 variants nxf-2, 37 accessions, 2 variants dhs-22, 52 accessions pas-1, 109 accessions 2 variants 5O904, 28 accessions, 2 variants rrbs-1, 31 accessions 2 variants egl-1, 11 accessions ZOOM OUT                 D:disease, C:conserved, I:interactions, R:regulation, P:publications         Read more...
Annotated mRNA diagrams back to top
Bibliography back to top
Please see this 1 article in PubMed.
? Gene Summary Gene on genome mRNA Expression Tissue Function, regulation, related genes C

To mine knowledge about the gene, please click the 'Gene Summary' or the 'Function, regulation, related genes ' tab at the top of the page. The 'Gene Summary' page includes all we learnt about the gene, functional annotations of neighboring genes, maps, links to other sites and the bibliography. The 'Function, regulation, related genes ' page includes Diseases (D), Pathways, GO annotations, conserved domains (C), interactions (I) reference into function, and pointers to all genes with the same functional annotation.
To see the mRNA diagram, sequence and annotation, click the 'mRNA' tab. To examine expression data from all cDNAs clustered in this gene by AceView, click the 'Expression tissue'.

If you know more about this gene, or found errors, please share your knowledge. Thank you !