Caenorhabditis elegans predicted gene cyn-12, encoding CYclophiliN, peptidyl-prolyl cis-trans isomerase.
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SUMMARY back to top
Summary
[Wormbase] cyn-12 encodes a member of the cyclophilin family that is related to human PPIL1 (CGI-124); based upon its sequence similarity, CYN-12 is predicted to be a cytoplasmic protein potentially involved in a wide range of signal transduction pathways.
Map on chromosome IV, links to other databases and other names
Map: This gene cyn-12 maps on chomosome IV at position +3.71 (interpolated).
Links to: WormBase, RNAiDB.
as Other names: The gene is also known cyp-12, in Wormgenes/AceView by its positional name 4H894, in Wormbase by its cosmid.number name C34D4.12.
EC number: This gene encodes protein number: EC 5.2.1.8.
Closest AceView homologs in other species ?
The closest human gene, according to BlastP, is the AceView gene PPIL1.
The closest mouse gene, according to BlastP, is the AceView gene Ppil1.
The closest A.thaliana gene, according to BlastP, is the AceView gene AT2G36130 (e=10-51)
          Complete gene on genome diagram: back to top
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This diagram shows in true scale the gene on the genome, the mRNAs and the cDNA clones.
Compact gene diagram back to top
Gene cyn-12 5' 3' encoded on minus strand of chromosome IV from 7,133,199 to 7,132,106 0bp 0 Alternative mRNAs are shown aligned from 5' to 3' on a virtual genome where introns have been shrunk to a minimal length. Exon size is proportional to length, intron height reflects the number of cDNAs supporting each intron, the small numbers show the support of the introns in deep sequencing (with details in mouse-over) . Introns of the same color are identical, of different colors are different. 'Good proteins' are pink, partial or not-good proteins are yellow, uORFs are green. 5' cap or3' poly A flags show completeness of the transcript.
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Sequences: click on the numbers to get the DNA back to top
Summaries of AceView transcripts and proteins back to top
Predicted protein properties back to top
Gene neighbors and Navigator on chromosome IV back to top
D C P ssq-3 D C nas-8 C R P str-48 C P str-49 P str-51 P str-50 P 4H913 C 4H919 C P 4H921 C P 4H874 grsp-3 C 4H882 C I P cyn-12 C 4H896 D C R P hecd-1 C P col-113 5kb 0 4H873, 17 accessions ssq-3, 16 accessions, 8 variants nas-8, 16 accessions str-48, 3 accessions str-49, 4 accessions, 2 variants str-51, 0 accession str-50, 0 accession 4H913, 12 accessions, 3 variants 4H919, 60 accessions 4H921, 30 accessions 4H871_2, 3 accessions 4H874, 9 accessions, 2 variants grsp-3, 11 accessions 4 variants 4H882, 10 accessions, 3 variants cyn-12, 0 accession 4H896, 8 accessions, 2 variants hecd-1, 150 accessions 13 variants col-113, 31 accessions 2 variants ZOOM OUT                 D:disease, C:conserved, I:interactions, R:regulation, P:publications         Read more...
Bibliography back to top
Please see this 1 article in PubMed.
? Gene Summary Gene on genome mRNA Expression Tissue Function, regulation, related genes CI

To mine knowledge about the gene, please click the 'Gene Summary' or the 'Function, regulation, related genes ' tab at the top of the page. The 'Gene Summary' page includes all we learnt about the gene, functional annotations of neighboring genes, maps, links to other sites and the bibliography. The 'Function, regulation, related genes ' page includes Diseases (D), Pathways, GO annotations, conserved domains (C), interactions (I) reference into function, and pointers to all genes with the same functional annotation.
To see the mRNA diagram, sequence and annotation, click the 'mRNA' tab. To examine expression data from all cDNAs clustered in this gene by AceView, click the 'Expression tissue'.

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