Caenorhabditis elegans gene cpr-4, encoding cysteine PRotease related.
SUMMARY back to top
[Wormbase] cpr-4 encodes a cathepsin B-like cysteine protease expressed at all life stages.
Wormbase predicts one model

AceView synopsis, each blue text links to tables and details
According to AceView, this gene is expressed at very high level, 7.9 times the average gene in this release, mostly from L1 larvae to adult [Kohara cDNAs]. The expression profile for the gene, derived from the proportion of animals at each stage in each Kohara library is: embryos 1%, L1 or L2 larvae 25%, L3 to adult (including dauer) 74%. See the in situ hybridization pattern in Kohara NextDB. The sequence of this gene is defined by 56 cDNA clones and 48 elements defined by RNA-seq, some from mixed (seen 15 times), l1 (8), l2 (6), l4 (5), whole animal (once). We annotate structural defects or features in 7 cDNA clones.
The gene contains 1 gt-ag intron. Transcription produces one mRNA.
Function: There are 2 articles specifically referring to this gene in PubMed. In addition we point below to 2 abstracts. Functionally, the gene has been proposed to participate in a process (proteolysis and peptidolysis). Proteins are expected to have molecular function (cysteine-type peptidase activity) and to localize in extracellular space.
The spliced mRNA putatively encodes a good protein, containing peptidase C1A, papain C-terminal domain [Pfam]; the complete protein appears to be secreted.

Please quote: AceView: a comprehensive cDNA-supported gene and transcripts annotation, Genome Biology 2006, 7(Suppl 1):S12.
Map on chromosome V, links to other databases and other names
Map: This gene cpr-4 maps on chomosome V at position +0.13 (interpolated). In AceView, it covers 1.26 kb, from 6614581 to 6615836 (WS190), on the direct strand.
Links to: WormBase, NextDB, RNAiDB.
Other names: The gene is also known in Wormgenes/AceView by its positional name 5H95, in Wormbase by its cosmid.number name F44C4.3, in NextDB, the Nematode expression pattern database, as CEYK2094.
Closest AceView homologs in other species ?
The closest human gene, according to BlastP, is the AceView gene CTSB.
The closest mouse gene, according to BlastP, is the AceView gene Ctsb (e=2 10-80).
The closest A.thaliana genes, according to BlastP, are the AceView genes AT4G01610, AT1G02300, AT1G02305
          Complete gene on genome diagram: back to top
Please choose between the zoomable GIF version., and the HTML5/SVG version.
This diagram shows in true scale the gene on the genome, the mRNAs and the cDNA clones.
Compact gene diagram back to top
Gene cpr-4 5' 3' encoded on plus strand of chromosome V from 6,614,621 to 6,615,836 a 100 200bp 0 117 bp exon 117 bp exon 237 bp uORF 117 bp exon 49 bp [gt-ag] intron 27 GenBank accessions 237 bp uORF 1088 bp exon 1088 bp exon 103 accessions, some from mixed (seen 14 times) l1 (8), l2 (6), l4 (5) whole animal (once) Validated 3' end, 267 accessions 1088 bp exon Alternative mRNAs are shown aligned from 5' to 3' on a virtual genome where introns have been shrunk to a minimal length. Exon size is proportional to length, intron height reflects the number of cDNAs supporting each intron, the small numbers show the support of the introns in deep sequencing (with details in mouse-over) . Introns of the same color are identical, of different colors are different. 'Good proteins' are pink, partial or not-good proteins are yellow, uORFs are green. 5' cap or3' poly A flags show completeness of the transcript.
Sequences: click on the numbers to get the DNA back to top
mRNA variant mRNA matching the genome Best predicted protein 5' UTR 3' UTR uORF Upstream sequence Transcription
Downstream sequence
a 1205 bp 335 aa 114 bp 83 bp 234 bp 2kb possibly including promoter 1254 bp 1kb

Gene neighbors and Navigator on chromosome V back to top
5H71 C hcp-1 D C I R P cpr-4 C P nhr-37 C R scd-2 D C I P 5H69 5H106 C R 5H80 C I P 5H82 D C I R P gon-14 C R P ppt-1 5kb 0 5H71, 6 accessions hcp-1, 64 accessions, 2 variants cpr-4, 104 accessions nhr-37, 9 accessions scd-2, 42 accessions, 2 variants 5H69, 5 accessions, 3 variants 5H106, 0 accession 5H80, 26 accessions, 8 variants 5H82, 89 accessions, 2 variants gon-14, 51 accessions 10 variants ppt-1, 46 accessions ZOOM OUT                 D:disease, C:conserved, I:interactions, R:regulation, P:publications         Read more...
Annotated mRNA diagrams back to top
Bibliography back to top
Please see these 2 articles in PubMed.
In addition we found 2 papers for which we do not have a PubMed identifier
? Gene Summary Gene on genome mRNA Expression Tissue Function, regulation, related genes C

To mine knowledge about the gene, please click the 'Gene Summary' or the 'Function, regulation, related genes ' tab at the top of the page. The 'Gene Summary' page includes all we learnt about the gene, functional annotations of neighboring genes, maps, links to other sites and the bibliography. The 'Function, regulation, related genes ' page includes Diseases (D), Pathways, GO annotations, conserved domains (C), interactions (I) reference into function, and pointers to all genes with the same functional annotation.
To see the mRNA diagram, sequence and annotation, click the 'mRNA' tab. To examine expression data from all cDNAs clustered in this gene by AceView, click the 'Expression tissue'.

If you know more about this gene, or found errors, please share your knowledge. Thank you !