Caenorhabditis elegans gene ard-1, encoding alcohol/Ribitol Dehydrogenase.
SUMMARY back to top
[Wormbase] ard-1 encodes a homolog of mammalian 3-hydroxyacyl-CoA dehydrogenase (HADH II)/amyloid-beta binding alcohol dehydrogenase (ABAD) that is predicted to be mitochondrial.
Wormbase predicts one model

AceView synopsis, each blue text links to tables and details
According to AceView, this gene is expressed at very high level, 10.5 times the average gene in this release, mostly in embryos, and some at all stages of development [Kohara cDNAs]. The expression profile for the gene, derived from the proportion of animals at each stage in each Kohara library is: embryos 47%, L1 or L2 larvae 22%, L3 to adult (including dauer) 32%. See the in situ hybridization pattern in Kohara NextDB. The sequence of this gene is defined by 27 cDNA clones and 111 elements defined by RNA-seq, some from embryo (seen 13 times), l2 (4), l4 (3), l1 (2), dauer (once). We annotate structural defects or features in 2 cDNA clones.
The gene contains 5 distinct gt-ag introns. Transcription produces one mRNA. Variant a is transpliced to SL3, SL1, SL2, SL5, SL4. There are 2 validated alternative polyadenylation sites (see the diagram).
Function: There are 3 articles specifically referring to this gene in PubMed. This gene is associated to a phenotype (shared oogenic and spermatogenic protein copurified with chromatin). Functionally, the gene has been proposed to participate in a process (metabolism). Proteins are expected to have molecular functions (coenzyme binding, enzyme activity, oxidoreductase activity) and to localize in cytoplasm.
The spliced mRNA putatively encodes a good protein, containing domains short-chain dehydrogenase/reductase SDR, NAD-dependent epimerase/dehydratase, Polyketide synthase, KR [Pfam].

Please quote: AceView: a comprehensive cDNA-supported gene and transcripts annotation, Genome Biology 2006, 7(Suppl 1):S12.
Map on chromosome IV, links to other databases and other names
Map: This gene ard-1 maps on chomosome IV at position +5.08 (interpolated). In AceView, it covers 2.53 kb, from 11131251 to 11133779 (WS190), on the direct strand.
Links to: WormBase, NextDB, RNAiDB.
Other names: The gene is also known in Wormgenes/AceView by its positional name 4L897, in Wormbase by its cosmid.number name F01G4.2, in NextDB, the Nematode expression pattern database, as CEYK5057.
Closest AceView homologs in other species ?
The closest human gene, according to BlastP, is the AceView gene HSD17B10.
The closest mouse genes, according to BlastP, are the AceView genes Hsd17b10 (e=3 10-81), Hsd17b10andSmc1a (e=3 10-81).
The closest A.thaliana genes, according to BlastP, are the AceView genes AT3G26770 (e=3 10-23), AT3G26760 (e=9 10-22), AT2G47120 (e=2 10-20), AT3G51680 (e=3 10-20), AT3G29250 (e=4 10-20), AT2G47130 (e=6 10-20), AT1G54870 (e=2 10-19)
          Complete gene on genome diagram: back to top
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This diagram shows in true scale the gene on the genome, the mRNAs and the cDNA clones.
Compact gene diagram back to top
Gene ard-1 5' 3' encoded on plus strand of chromosome IV from 11,131,251 to 11,133,779 a 1kb 0 38 bp exon 38 bp exon 83 bp [gt-ag] intron 21 GenBank accessions 159 bp exon 782 bp [gt-ag] intron 25 GenBank accessions 165 bp exon 47 bp [gt-ag] intron 26 GenBank accessions 138 bp exon 629 bp [gt-ag] intron 27 GenBank accessions 141 bp exon 50 bp [gt-ag] intron 28 GenBank accessions 297 bp exon 138 accessions, some from embryo (seen 13 times) l2 (4), l4 (3), l1 (2) dauer (once) Transpliced 5' end, 7 accessions Validated 3' end, 3 accessions Validated 3' end, 552 accessions 297 bp exon Alternative mRNAs are shown aligned from 5' to 3' on a virtual genome where introns have been shrunk to a minimal length. Exon size is proportional to length, intron height reflects the number of cDNAs supporting each intron, the small numbers show the support of the introns in deep sequencing (with details in mouse-over) . Introns of the same color are identical, of different colors are different. 'Good proteins' are pink, partial or not-good proteins are yellow, uORFs are green. 5' cap or3' poly A flags show completeness of the transcript.
Sequences: click on the numbers to get the DNA back to top
mRNA variant mRNA matching the genome Best predicted protein 5' UTR 3' UTR Upstream sequence Transcription
Downstream sequence
a 938 bp 258 aa 14 bp 147 bp 2kb including Promoter 2529 bp 1kb

Gene neighbors and Navigator on chromosome IV back to top
4L879 C 4L887 D C I P psa-4 D C I R P ard-1 D C P 4L909 D C R P 4L917 D C P pfd-1 D C P 4L921 C D C 4L872 D C I R P rps-5 D C R P imp-2 D C I P spo-11 C 4L900 C 4L910 D C R P 4L912 5kb 0 4L879, 9 accessions, 2 variants 4L887, 251 accessions 2 variants psa-4, 152 accessions ard-1, 138 accessions 4L909, 15 accessions, 4 variants 4L917, 89 accessions, 5 variants pfd-1, 0 accession 4L921, 31 accessions, 4 variants 4L871, 45 accessions 4L872, 2161 accessions 5 variants rps-5, 0 accession imp-2, 24 accessions, 2 variants spo-11, 29 accessions 3 variants 4L900, 34 accessions, 3 variants 4L910, 0 accession 4L912, 544 accessions 5 variants ZOOM OUT                 D:disease, C:conserved, I:interactions, R:regulation, P:publications         Read more...
Annotated mRNA diagrams back to top
Bibliography back to top
Please see these 3 articles in PubMed.
? Gene Summary Gene on genome mRNA Expression Tissue Function, regulation, related genes DC

To mine knowledge about the gene, please click the 'Gene Summary' or the 'Function, regulation, related genes ' tab at the top of the page. The 'Gene Summary' page includes all we learnt about the gene, functional annotations of neighboring genes, maps, links to other sites and the bibliography. The 'Function, regulation, related genes ' page includes Diseases (D), Pathways, GO annotations, conserved domains (C), interactions (I) reference into function, and pointers to all genes with the same functional annotation.
To see the mRNA diagram, sequence and annotation, click the 'mRNA' tab. To examine expression data from all cDNAs clustered in this gene by AceView, click the 'Expression tissue'.

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