Homo sapiens gene TTTY3B, encoding testis-specific transcript, Y-linked 3B (non-protein coding).
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SUMMARY back to top
RefSeq summary
[TTTY3B] There are two copies of this gene within the P1 palindrome on chromosome Y. This record represents the more centromeric copy. [provided by RefSeq].

RefSeq annotates one representative transcript.

AceView synopsis, each blue text links to tables and details
According to AceView, this gene is expressed at low level, only 0.9% of the average gene in this release. The sequence of this gene is defined by 3 GenBank accessions, some from testis (seen once).
The gene contains 2 distinct gt-ag introns. Transcription produces one mRNA.
Function: There is one article specifically referring to this gene in PubMed. No phenotype has yet been reported to our knowledge: this gene's in vivo function is yet unknown.
No 'good' large or conserved protein is encoded by this gene, which might be considered non-coding.

Please quote: AceView: a comprehensive cDNA-supported gene and transcripts annotation, Genome Biology 2006, 7(Suppl 1):S12.
Map on chromosome Y, links to other databases and other names
Map: This gene TTTY3B maps on chromosome Y, at Yq11.223 according to Entrez Gene. In AceView, it covers 4.90 kb, from 26087769 to 26082874 (NCBI 37, August 2010), on the reverse strand.
Links to: the SNP view, gene overviews from Entrez Gene 474148, GeneCards, expression data from ECgene, molecular and other annotations from UCSC. The previous AceView annotation is here.
Other names: The gene is also known as TTTY3B or NCRNA00122, LOC474148.
RNA_seq discoveries back to top
Expression/conservation in primates tissues evaluated by cross-mapping to human. back to top
TTTY3B Gene expression in 15 primates, 16 tissues, from the NHPRTR project in sFPKM BAB SkeletalMuscle WholeBlood CHP Kidney Liver Lung Spleen CMC CMM Cerebellum HUM Brain Colon Heart LymphNode Ovary Testis JMI BoneMarrow MLM OWL PTM RMC RMI Pituitary SQM Thymus MST SMY RTL Expression quantiles None Weak 1 2 3 4 5 6 7 8 10 20 This gene All genes log2 distributions RNA-seq gene expression profile across 16 selected tissues from the Non-Human Primates Reference Transcriptome Resource (link to NHPRTR project).
- Primates: Apes (HUM: Human (Illumina BodyMap 2), CHP: Chimpanzee), Old World monkeys (PTM: Pig-Tailed Macaque, JMI Japanese Macaque, RMI Rhesus Macaque Indian, RMC Rhesus Macaque Chinese, CMM Cynomolgus Macaque Mauritian, CMC Cynomolgus Macaque Chinese, BAB Olive Baboon, SMY Sooty Mangabey); New World monkeys (MST common Marmoset, SQM Squirrel Monkey, OWL Owl Monkey); and Lemurs (MLM Mouse Lemur, RTL Ring-Tailed Lemur).
- The level for significantly expressed genes is color coded in 8 equal sized bins (light to dark green). Light gray is for weak not-accurately measured expression (2 to 8 reads above intergenic background); dark gray for no expression or no sequence conservation (0 read in gene). The plot to the right shows the distribution of measured expression values in all tissues for all genes (blue) and for this gene (green), in Magic index = log2(1000 sFPKM).
You may also examine the strand-specific genome coverage plots on the experimental AceView/Magic hub at UCSC, by tissue or by species. Tracks may be slow to load; please reload if some tracks come up yellow-greenish, and thanks to UCSC for the great work!.
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          Complete gene on genome diagram: back to top
Please choose between the zoomable GIF version., and the HTML5/SVG version.
This diagram shows in true scale the gene on the genome, the mRNAs and the cDNA clones.
Compact gene diagram back to top
Gene TTTY3B 5' 3' encoded on minus strand of chromosome Y from 26,087,769 to 26,082,874 3 3 a 500bp 0 104 bp exon 104 bp exon 2198 bp [gt-ag] intron 3 GenBank accessions 135 bp exon 135 bp exon 2354 bp [gt-ag] intron 3 GenBank accessions 3 accessions, some from testis (seen once) 105 bp exon Alternative mRNAs are shown aligned from 5' to 3' on a virtual genome where introns have been shrunk to a minimal length. Exon size is proportional to length, intron height reflects the number of cDNAs supporting each intron, the small numbers show the support of the introns in deep sequencing (with details in mouse-over) . Introns of the same color are identical, of different colors are different. 'Good proteins' are pink, partial or not-good proteins are yellow, uORFs are green. 5' cap or3' poly A flags show completeness of the transcript.
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Sequences: click on the numbers to get the DNA back to top
mRNA variant mRNA matching the genome Best predicted protein 5' UTR 3' UTR Upstream sequence Transcription
unit
pre-mRNA
Downstream sequence
aAug10 344 bp 26 aa 42 bp 221 bp 2kb probably including promoter 4896 bp 1kb

Gene neighbors and Navigator on chromosome Yq11.223 back to top
OFD1P10Y P NCRNA00266B C P RBMY2CP P PRYP3 P TTTY3B D C I R P CDY1B C P CSPG4P2Y C R P GOLGA2P2Y P RPL41P7 100kb 0 OFD1P10Y, 1 accession chorbor, 2 accessions skeebo, 1 accession kardu, 1 accession slorbee, 2 accessions deybor, 1 accession bodu, 2 accessions slorbey, 1 accession NCRNA00266B, 1 accession glujy, 2 accessions sherdy, 1 accession kybu, 1 accession wabor, 1 accession snabo, 1 accession peybor, 1 accession wari, 1 accession kubu, 4 accessions gabor, 3 accessions foybor, 1 accession lorbu, 1 accession fawbor, 1 accession darbor, 1 accession bawdu, 1 accession RBMY2CP, 1 accession PRYP3, 15 accessions TTTY3B, 3 accessions CDY1B, 40 accessions, 2 variants CSPG4P2Y, 3 accessions GOLGA2P2Y, 3 accessions RPL41P7, 1 accession ZOOM IN                D:disease,C:conserved,I:interactions,R:regulation,P:publications         Read more...
Annotated mRNA diagrams back to top
Bibliography:               1 article in PubMed back to top
? Gene Summary Gene on genome mRNA Expression Tissue

To mine knowledge about the gene, please click the 'Gene Summary' or the 'Function, regulation, related genes ' tab at the top of the page. The 'Gene Summary' page includes all we learnt about the gene, functional annotations of neighboring genes, maps, links to other sites and the bibliography. The 'Function, regulation, related genes ' page includes Diseases (D), Pathways, GO annotations, conserved domains (C), interactions (I) reference into function, and pointers to all genes with the same functional annotation.
To see the mRNA diagram, sequence and annotation, click the 'mRNA' tab. To examine expression data from all cDNAs clustered in this gene by AceView, click the 'Expression tissue'.

If you know more about this gene, or found errors, please share your knowledge. Thank you !