Homo sapiens gene RASSF10, encoding Ras association (RalGDS/AF-6) domain family (N-terminal) member 10.
TABLE OF CONTENTS / OPEN CLOSE ALL PARAGRAPHS
SUMMARY back to top
RefSeq annotates one representative transcript.

AceView synopsis, each blue text links to tables and details
According to AceView, this gene is expressed at low level, only 0.9% of the average gene in this release. The sequence of this gene is defined by 2 GenBank accessions, some from adenocarcinoma, cell line (seen once), liver (once).
The gene contains 1 gt-ag intron. Transcription produces one spliced mRNA, 1 alternatively spliced variant and 1 unspliced form.
Function: There are 3 articles specifically referring to this gene in PubMed. Functionally, the gene has been tested for association to diseases (Precursor Cell Lymphoblastic Leukemia-Lymphoma; Thyroid Neoplasms) and proposed to participate in a process (signal transduction).
Protein coding potential: The spliced and the unspliced mRNAs putatively encode good proteins, altogether 2 different isoforms (2 COOH complete), containing a vacuolar domain, a coiled coil stretch [Psort2].

Please quote: AceView: a comprehensive cDNA-supported gene and transcripts annotation, Genome Biology 2006, 7(Suppl 1):S12.
Map on chromosome 11, links to other databases and other names
Map: This gene RASSF10 maps on chromosome 11, at 11p15.2 according to Entrez Gene. In AceView, it covers 1.95 kb, from 13030696 to 13032647 (NCBI 37, August 2010), on the direct strand.
Links to: the SNP view, gene overviews from Entrez Gene 644943, GeneCards, expression data from ECgene, UniGene, molecular and other annotations from UCSC. The previous AceView annotation is here.
Other names: The gene is also known as RASSF10, LOC644943. It has been described as ras association domain-containing protein 10, peptidylglycine alpha-amidating monooxygenase COOH-terminal interactor-like.
Closest AceView homologs in other species ?
The closest mouse gene, according to BlastP, is the AceView gene 4632411J06Rik (e=10-22)
RNA_seq discoveries back to top
Expression/conservation in primates tissues evaluated by cross-mapping to human. back to top
RASSF10 Gene expression in 15 primates, 16 tissues, from the NHPRTR project in sFPKM BAB SkeletalMuscle WholeBlood CHP Kidney Liver Lung Spleen CMC CMM Cerebellum HUM Brain Colon Heart LymphNode Ovary Testis JMI BoneMarrow MLM OWL PTM RMC RMI Pituitary SQM Thymus MST SMY RTL 0.17 1.10 0.59 0.19 0.08 0.04 0.08 1.55 0.18 0.09 0.17 0.29 1.02 1.10 0.10 0.15 0.24 0.48 1.10 0.11 0.22 0.17 0.42 0.13 0.89 4.10 0.19 0.21 0.26 0.12 0.39 0.15 0.63 0.13 0.10 0.12 0.18 0.11 0.29 0.63 0.24 0.14 0.27 0.08 0.14 0.24 0.24 1.18 0.21 0.17 0.16 0.11 0.13 0.96 0.14 0.12 0.12 0.59 0.15 0.22 0.39 0.21 0.16 0.27 0.34 1.55 0.21 1.55 0.19 0.36 0.51 0.13 0.16 0.10 0.07 0.22 0.22 0.10 0.12 5.04 0.34 0.14 0.17 0.39 0.36 1.78 1.26 0.29 0.42 0.18 1.78 0.45 0.21 0.14 0.21 Expression quantiles None Weak 1 2 3 4 5 6 7 8 10 20 This gene All genes log2 distributions RNA-seq gene expression profile across 16 selected tissues from the Non-Human Primates Reference Transcriptome Resource (link to NHPRTR project).
- Primates: Apes (HUM: Human (Illumina BodyMap 2), CHP: Chimpanzee), Old World monkeys (PTM: Pig-Tailed Macaque, JMI Japanese Macaque, RMI Rhesus Macaque Indian, RMC Rhesus Macaque Chinese, CMM Cynomolgus Macaque Mauritian, CMC Cynomolgus Macaque Chinese, BAB Olive Baboon, SMY Sooty Mangabey); New World monkeys (MST common Marmoset, SQM Squirrel Monkey, OWL Owl Monkey); and Lemurs (MLM Mouse Lemur, RTL Ring-Tailed Lemur).
- The level for significantly expressed genes is color coded in 8 equal sized bins (light to dark green). Light gray is for weak not-accurately measured expression (2 to 8 reads above intergenic background); dark gray for no expression or no sequence conservation (0 read in gene). The plot to the right shows the distribution of measured expression values in all tissues for all genes (blue) and for this gene (green), in Magic index = log2(1000 sFPKM).
You may also examine the strand-specific genome coverage plots on the experimental AceView/Magic hub at UCSC, by tissue or by species. Tracks may be slow to load; please reload if some tracks come up yellow-greenish, and thanks to UCSC for the great work!.
Read more...
          Complete gene on genome diagram: back to top
Please choose between the zoomable GIF version., and the HTML5/SVG version.
This diagram shows in true scale the gene on the genome, the mRNAs and the cDNA clones.
Compact gene diagram back to top
Gene RASSF10 5' 3' encoded on plus strand of chromosome 11 from 13,030,696 to 13,032,647 1 a [NM] 100 200bp 0 283 bp exon 104 bp [gt-ag] intron only supported by one RefSeq model 1 accession, NM_001080521.1 1565 bp exon 652 bp exon 652 bp exon 652 bp exon Alternative mRNAs are shown aligned from 5' to 3' on a virtual genome where introns have been shrunk to a minimal length. Exon size is proportional to length, intron height reflects the number of cDNAs supporting each intron, the small numbers show the support of the introns in deep sequencing (with details in mouse-over) . Introns of the same color are identical, of different colors are different. 'Good proteins' are pink, partial or not-good proteins are yellow, uORFs are green. 5' cap or3' poly A flags show completeness of the transcript.
Read more...
Sequences: click on the numbers to get the DNA back to top
mRNA variant mRNA matching the genome Best predicted protein 3' UTR Upstream sequence Transcription
unit
pre-mRNA
Downstream sequence
aAug10 1848 bp 615 aa 2kb 1952 bp 1kb
bAug10-unspliced 652 bp 204 aa 36 bp 2kb 652 bp 1kb

Gene neighbors and Navigator on chromosome 11p15.2 back to top
TEAD1 D C I R P RASSF10 D C P R ARNTL D C I R P R R R D C I R P BTBD10 100kb 0 PARVA, 572 accessions 12 variants TEAD1, 426 accessions 7 variants RASSF10, 2 accessions 2 variants gleemee, 16 accessions ARNTL, 233 accessions 28 variants klymee, 6 accessions sporkeyby, 2 accessions wysloyby, 1 accession sheyflerbu, 1 accession stykeyby, 1 accession rakera, 104 accessions 2 variants stokeyby, 2 accessions shorflerbu, 2 accessions blaflerbu, 1 accession blyflerbu, 1 accession sterkeyby, 1 accession glawgoby, 4 accessions 2 variants sotemi, 2 accessions stoykeyby, 1 accession swykeyby, 3 accessions katemi, 2 accessions, 2 variants blawflerbu, 1 accession swukeyby, 2 accessions bleeflerbu, 1 accession swarkeyby, 1 accession sweekeyby, 1 accession chysloyby, 2 accessions sworkeyby, 2 accessions swoykeyby, 1 accession bakorby, 1 accession bykorby, 3 accessions chorsloyby, 1 accession smytubo, 1 accession sharsloyby, 1 accession bokorby, 1 accession blosloyby, 1 accession plogoby, 1 accession barkorby, 1 accession beekorby, 2 accessions blarsloyby, 1 accession smutubo, 2 accessions rumiro, 1 accession nocher, 3 accessions flaflerbu, 1 accession borkorby, 1 accession smygoby, 12 accessions boykorby, 2 accessions dakorby, 2 accessions dykorby, 1 accession dukorby, 2 accessions dokorby, 1 accession darkorby, 5 accessions deykorby, 4 accessions blawsloyby, 1 accession smotubo, 2 accessions smartubo, 1 accession farkorby, 1 accession glamee, 1 accession ferkorby, 1 accession fleeflerbu, 1 accession kygloy, 2 accessions foykorby, 1 accession spygoby, 1 accession gakorby, 2 accessions skafaw, 3 accessions lygloy, 1 accession gawkorby, 3 accessions geekorby, 1 accession swagoby, 4 accessions florsloyby, 1 accession glosloyby, 1 accession glawsloyby, 1 accession klasloyby, 1 accession geykorby, 1 accession jykorby, 1 accession kleesloyby, 1 accession jukorby, 1 accession nawcher, 3 accessions jarkorby, 1 accession plersloyby, 1 accession jawkorby, 1 accession slysloyby, 1 accession kakorby, 1 accession kykorby, 2 accessions kukorby, 4 accessions margloy, 1 accession gluflerbu, 1 accession gloflerbu, 1 accession glarflerbu, 1 accession kawkorby, 1 accession smofaw, 1 accession remiro, 1 accession lakorby, 1 accession lykorby, 1 accession sneysloyby, 1 accession romiro, 1 accession spusloyby, 1 accession gagarby, 1 accession larkorby, 1 accession lawkorby, 1 accession gleyflerbu, 3 accessions lerkorby, 1 accession sparsloyby, 1 accession leykorby, 1 accession klaflerbu, 1 accession loykorby, 1 accession klyflerbu, 2 accessions kitemi, 2 accessions, 2 variants stosloyby, 1 accession mykorby, 2 accessions kluflerbu, 1 accession storsloyby, 1 accession seegloy, 1 accession klamee, 1 accession tawgloy, 1 accession speykeyby, 2 accessions spoykeyby, 1 accession wusloyby, 2 accessions starkeyby, 2 accessions steekeyby, 1 accession shoyflerbu, 1 accession bloflerbu, 1 accession steykeyby, 1 accession klogoby, 3 accessions 2 variants zusloyby, 1 accession swokeyby, 1 accession zeysloyby, 2 accessions chasloyby, 1 accession swawkeyby, 2 accessions flermee, 1 accession swerkeyby, 1 accession sweykeyby, 1 accession blerflerbu, 1 accession chusloyby, 1 accession sheesloyby, 1 accession bawkorby, 1 accession fleymee, 8 accessions derkorby, 5 accessions dorkorby, 1 accession fakorby, 1 accession snawgoby, 1 accession fokorby, 1 accession fawkorby, 1 accession glymee, 1 accession feekorby, 1 accession sneegoby, 3 accessions bleesloyby, 1 accession gykorby, 2 accessions flasloyby, 1 accession gukorby, 2 accessions storgoby, 1 accession garkorby, 1 accession flusloyby, 1 accession gerkorby, 1 accession lawgloy, 1 accession jakorby, 1 accession klosloyby, 1 accession klorsloyby, 1 accession magloy, 1 accession plosloyby, 2 accessions fleyflerbu, 1 accession florflerbu, 3 accessions skoysloyby, 2 accessions neecher, 13 accessions 2 variants jerkorby, 2 accessions jeykorby, 1 accession jorkorby, 1 accession floyflerbu, 2 accessions sleesloyby, 5 accessions slusloyby, 1 accession seriro, 4 accessions sloysloyby, 1 accession kokorby, 1 accession choyskerby, 1 accession mawgloy, 1 accession slufaw, 4 accessions glawflerbu, 1 accession keekorby, 1 accession gleeflerbu, 1 accession kerkorby, 1 accession keykorby, 2 accessions korkorby, 1 accession boygarby, 1 accession snersloyby, 1 accession lukorby, 1 accession nawgloy, 1 accession lokorby, 1 accession glorflerbu, 2 accessions jagarby, 15 accessions norcher, 2 accessions makorby, 3 accessions smeetubo, 2 accessions rugloy, 1 accession markorby, 1 accession klarflerbu, 1 accession noycher, 2 accessions merkorby, 1 accession tugloy, 1 accession meykorby, 1 accession morkorby, 2 accessions moykorby, 1 accession nakorby, 1 accession kleeflerbu, 1 accession rukera, 49 accessions 12 variants glermee, 5 accessions BTBD10, 345 accessions 18 variants ZOOM IN                D:disease,C:conserved,I:interactions,R:regulation,P:publications         Read more...
Annotated mRNA diagrams back to top
Bibliography:               3 articles in PubMed back to top
? Gene Summary Gene on genome mRNA:.a, .b-u Alternative mRNAs features, proteins, introns, exons, sequences Expression Tissue Function, regulation, related genes DC

To mine knowledge about the gene, please click the 'Gene Summary' or the 'Function, regulation, related genes ' tab at the top of the page. The 'Gene Summary' page includes all we learnt about the gene, functional annotations of neighboring genes, maps, links to other sites and the bibliography. The 'Function, regulation, related genes ' page includes Diseases (D), Pathways, GO annotations, conserved domains (C), interactions (I) reference into function, and pointers to all genes with the same functional annotation.
To compare alternative variants, their summarized annotations, predicted proteins, introns and exons, or to access any sequence, click the 'Alternative mRNAs features' tab. To see a specific mRNA variant diagram, sequence and annotation, click the variant name in the 'mRNA' tab. To examine expression data from all cDNAs clustered in this gene by AceView, click the 'Expression tissue'.

If you know more about this gene, or found errors, please share your knowledge. Thank you !