Homo sapiens gene GPR101, encoding G protein-coupled receptor 101.
TABLE OF CONTENTS / OPEN CLOSE ALL PARAGRAPHS
SUMMARY back to top
RefSeq summary
[GPR101] G protein-coupled receptors (GPCRs, or GPRs) contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.[supplied by OMIM].

RefSeq annotates one representative transcript.

AceView synopsis, each blue text links to tables and details
According to AceView, this gene is expressed at low level, only 14.8% of the average gene in this release. The sequence of this gene is defined by 17 GenBank accessions, some from prostate normal (seen once).
Function: There are 2 articles specifically referring to this gene in PubMed. Proteins are expected to have molecular function (G-protein coupled receptor activity) and to localize in various compartments (plasma membrane, integral to membrane). No phenotype has yet been reported to our knowledge: this gene's in vivo function is yet unknown.
. This gene contains domains 7 transmembrane receptor (rhodopsin family), Serpentine type 7TM GPCR chemoreceptor Srsx [Pfam], some transmembrane domains [Psort2].

Please quote: AceView: a comprehensive cDNA-supported gene and transcripts annotation, Genome Biology 2006, 7(Suppl 1):S12.
Map on chromosome X, links to other databases and other names
Map: This gene GPR101 maps on chomosome X at position +2974799101952.00 (interpolated), at Xq26.3 according to Entrez Gene. In AceView, it covers 1.70 kb, from 136114005 to 136112303 (NCBI 37, August 2010), on the reverse strand.
Links to: the SNP view, gene overviews from Entrez Gene 83550, GeneCards, expression data from ECgene, UniGene, molecular and other annotations from UCSC, or our GOLD analysis.
The previous AceView annotation is here.
Other names: The gene is also known as GPR101 or GPCR6, LOC83550. It has been described as probable G-protein coupled receptor 101.
Closest AceView homologs in other species ?
The closest mouse gene, according to BlastP, is the AceView gene Gpr101 (e=0.0).
The closest C.elegans genes, according to BlastP, are the AceView/WormGenes XG226 (e=10-16), tyra-2 (e=4 10-16), ser-4 (e=2 10-14), which may contain interesting functional annotation
RNA_seq discoveries back to top
Expression/conservation in primates tissues evaluated by cross-mapping to human. back to top
GPR101 Gene expression in 15 primates, 16 tissues, from the NHPRTR project in sFPKM BAB SkeletalMuscle WholeBlood CHP Kidney Liver Lung Spleen CMC CMM Cerebellum HUM Brain Colon Heart LymphNode Ovary Testis JMI BoneMarrow MLM OWL PTM RMC RMI Pituitary SQM Thymus MST SMY RTL 4.10 0.14 1.02 0.15 0.11 0.42 0.22 0.72 0.08 0.15 0.39 1.66 0.63 0.55 0.11 0.34 0.15 0.22 0.13 1.35 0.14 1.10 0.17 0.45 0.96 0.16 0.18 0.16 0.08 0.21 5.04 0.15 0.26 0.36 0.21 0.55 Expression quantiles None Weak 1 2 3 4 5 6 7 8 10 20 This gene All genes log2 distributions RNA-seq gene expression profile across 16 selected tissues from the Non-Human Primates Reference Transcriptome Resource (link to NHPRTR project).
- Primates: Apes (HUM: Human (Illumina BodyMap 2), CHP: Chimpanzee), Old World monkeys (PTM: Pig-Tailed Macaque, JMI Japanese Macaque, RMI Rhesus Macaque Indian, RMC Rhesus Macaque Chinese, CMM Cynomolgus Macaque Mauritian, CMC Cynomolgus Macaque Chinese, BAB Olive Baboon, SMY Sooty Mangabey); New World monkeys (MST common Marmoset, SQM Squirrel Monkey, OWL Owl Monkey); and Lemurs (MLM Mouse Lemur, RTL Ring-Tailed Lemur).
- The level for significantly expressed genes is color coded in 8 equal sized bins (light to dark green). Light gray is for weak not-accurately measured expression (2 to 8 reads above intergenic background); dark gray for no expression or no sequence conservation (0 read in gene). The plot to the right shows the distribution of measured expression values in all tissues for all genes (blue) and for this gene (green), in Magic index = log2(1000 sFPKM).
You may also examine the strand-specific genome coverage plots on the experimental AceView/Magic hub at UCSC, by tissue or by species. Tracks may be slow to load; please reload if some tracks come up yellow-greenish, and thanks to UCSC for the great work!.
Read more...
          Complete gene on genome diagram: back to top
Please choose between the zoomable GIF version., and the HTML5/SVG version.
This diagram shows in true scale the gene on the genome, the mRNAs and the cDNA clones.
Compact gene diagram back to top
Gene GPR101 5' 3' encoded on minus strand of chromosome X from 136,114,005 to 136,112,303 100 200bp 0 1699 bp exon 1699 bp exon Alternative mRNAs are shown aligned from 5' to 3' on a virtual genome where introns have been shrunk to a minimal length. Exon size is proportional to length, intron height reflects the number of cDNAs supporting each intron, the small numbers show the support of the introns in deep sequencing (with details in mouse-over) . Introns of the same color are identical, of different colors are different. 'Good proteins' are pink, partial or not-good proteins are yellow, uORFs are green. 5' cap or3' poly A flags show completeness of the transcript.
Read more...
Sequences: click on the numbers to get the DNA back to top
mRNA variant mRNA matching the genome Best predicted protein 5' UTR Upstream sequence Transcription
unit
pre-mRNA
Downstream sequence
aAug10-unspliced 1699 bp 508 aa 172 bp 2kb possibly including promoter 1699 bp 1kb

Gene neighbors and Navigator on chromosome Xq26.3 back to top
R CD40LG D C I R P C R C D C I R P ARHGEF6 G D C I R P RBMXandSNORD61 C P GPR101 P RAC1P4 100kb 0 VGLL1, 142 accessions 6 variants shertoy, 11 accessions 3 variants CD40LG, 34 accessions 3 variants sporlee, 3 accessions fleeny, 42 accessions 12 variants glony, 2 accessions chorny, 1 accession shany, 1 accession glardar, 1 accession sharny, 1 accession shawny, 1 accession klaga, 2 accessions ploga, 1 accession gleedar, 1 accession snalee, 1 accession sneylee, 1 accession yase, 2 accessions, 2 variants dorler, 1 accession blorny, 1 accession feyler, 1 accession bloyny, 1 accession smorga, 1 accession dosubo, 1 accession pladar, 1 accession fluny, 1 accession snaga, 1 accession jerler, 1 accession sterga, 1 accession loler, 3 accessions swaga, 1 accession gleeny, 1 accession dagy, 2 accessions glerny, 1 accession nase, 2 accessions, 2 variants fafo, 1 accession flerdar, 1 accession shyny, 1 accession shuny, 1 accession glawvar, 7 accessions sworfu, 1 accession gleyga, 1 accession sleelee, 1 accession ruse, 2 accessions, 2 variants shorny, 2 accessions shoyny, 1 accession bluny, 12 accessions smeylee, 1 accession smoylee, 2 accessions glerdar, 1 accession beefo, 2 accessions bleyny, 1 accession doler, 1 accession fuler, 1 accession gleydar, 1 accession flyny, 2 accessions sehuru, 1 accession flony, 1 accession pleedar, 3 accessions fleyny, 1 accession deyfo, 1 accession gluny, 4 accessions pleydar, 1 accession swoyga, 3 accessions hese, 3 accessions, 2 variants plordar, 1 accession klyny, 1 accession ploydar, 1 accession ARHGEF6, 253 accessions 16 variants LOC100130621, 18 accessions RBMXandSNORD61, 747 accessions 24 variants GPR101, 17 accessions RAC1P4, 1 accession ZOOM IN                D:disease,C:conserved,I:interactions,R:regulation,P:publications         Read more...
Annotated mRNA diagrams back to top
Bibliography:               2 articles in PubMed back to top
? Gene Summary Gene on genome mRNA Expression Tissue Function, regulation, related genes C

To mine knowledge about the gene, please click the 'Gene Summary' or the 'Function, regulation, related genes ' tab at the top of the page. The 'Gene Summary' page includes all we learnt about the gene, functional annotations of neighboring genes, maps, links to other sites and the bibliography. The 'Function, regulation, related genes ' page includes Diseases (D), Pathways, GO annotations, conserved domains (C), interactions (I) reference into function, and pointers to all genes with the same functional annotation.
To see the mRNA diagram, sequence and annotation, click the 'mRNA' tab. To examine expression data from all cDNAs clustered in this gene by AceView, click the 'Expression tissue'.

If you know more about this gene, or found errors, please share your knowledge. Thank you !