Homo sapiens gene F8A3, encoding coagulation factor VIII-associated (intronic transcript) 3.
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SUMMARY back to top
RefSeq summary
[F8A3] This gene is part of a region that is repeated three times on chromosome X, once in intron 22 of the F8 gene and twice closer to the Xq telomere. This record represents the most telomeric copy. Although its function is unknown, the observation that this gene is conserved in the mouse implies it has some function. Unlike factor VIII, this gene is transcribed abundantly in a wide variety of cell types. [provided by RefSeq].

RefSeq annotates one representative transcript.

AceView synopsis, each blue text links to tables and details
According to AceView, this gene is well expressed, 1.4 times the average gene in this release. The sequence of this gene is defined by 167 GenBank accessions from 151 cDNA clones, some from neuroblastoma cot 25-normalized (seen 12 times), brain (11), breast (11), colon (7), lung (7), t-lymphocytes (7), uterus (7) and 73 other tissues. We annotate structural defects or features in 5 cDNA clones.
Function: There are 2 articles specifically referring to this gene in PubMed. Proteins are expected to localize in nucleus. No phenotype has yet been reported to our knowledge: this gene's in vivo function is yet unknown.

Please quote: AceView: a comprehensive cDNA-supported gene and transcripts annotation, Genome Biology 2006, 7(Suppl 1):S12.
Map on chromosome X, links to other databases and other names
Map: This gene F8A3 maps on chomosome X at position +10073719963648.00 (interpolated), at Xq28 according to Entrez Gene. In AceView, it covers 75.65 kb, from 154688402 to 154612749 (NCBI 37, August 2010), on the reverse strand.
Links to: the SNP view, gene overviews from Entrez Gene 474384, GeneCards, expression data from UniGene Hs.533543, Hs.593687, molecular and other annotations from UCSC, or our GOLD analysis.
The previous AceView annotation is here.
Other names: The gene is also known as F8A3, F8A1, F8A2, LOC474384 or porfy, warfy. It has been described as factor VIII intron 22 protein, cpG island protein.
Closest AceView homologs in other species ?
The closest mouse gene, according to BlastP, is the AceView gene F8a (e= 10-104)
RNA_seq discoveries back to top
Expression/conservation in primates tissues evaluated by cross-mapping to human. back to top
F8A3 Gene expression in 15 primates, 16 tissues, from the NHPRTR project in sFPKM BAB SkeletalMuscle WholeBlood CHP Kidney Liver Lung Spleen CMC CMM Cerebellum HUM Brain Colon Heart LymphNode Ovary Testis JMI BoneMarrow MLM OWL PTM RMC RMI Pituitary SQM Thymus MST SMY RTL 2.70 2.52 2.35 3.82 4.10 1.02 2.52 3.57 2.52 2.19 5.04 4.39 5.04 5.79 Expression quantiles None Weak 1 2 3 4 5 6 7 8 10 20 This gene All genes log2 distributions RNA-seq gene expression profile across 16 selected tissues from the Non-Human Primates Reference Transcriptome Resource (link to NHPRTR project).
- Primates: Apes (HUM: Human (Illumina BodyMap 2), CHP: Chimpanzee), Old World monkeys (PTM: Pig-Tailed Macaque, JMI Japanese Macaque, RMI Rhesus Macaque Indian, RMC Rhesus Macaque Chinese, CMM Cynomolgus Macaque Mauritian, CMC Cynomolgus Macaque Chinese, BAB Olive Baboon, SMY Sooty Mangabey); New World monkeys (MST common Marmoset, SQM Squirrel Monkey, OWL Owl Monkey); and Lemurs (MLM Mouse Lemur, RTL Ring-Tailed Lemur).
- The level for significantly expressed genes is color coded in 8 equal sized bins (light to dark green). Light gray is for weak not-accurately measured expression (2 to 8 reads above intergenic background); dark gray for no expression or no sequence conservation (0 read in gene). The plot to the right shows the distribution of measured expression values in all tissues for all genes (blue) and for this gene (green), in Magic index = log2(1000 sFPKM).
You may also examine the strand-specific genome coverage plots on the experimental AceView/Magic hub at UCSC, by tissue or by species. Tracks may be slow to load; please reload if some tracks come up yellow-greenish, and thanks to UCSC for the great work!.
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          Complete gene on genome diagram: back to top
Please choose between the zoomable GIF version., and the HTML5/SVG version.
This diagram shows in true scale the gene on the genome, the mRNAs and the cDNA clones.
Compact gene diagram back to top
Gene F8A3 5' 3' encoded on minus strand of chromosome X from 154,688,402 to 154,612,749 a-u [NM] b-u [NM] 500bp 0 30 accessions, NM_001007523.1 NM_001007524.1, some from t-lymphocytes (seen 7 times) brain (5), neuroblastoma cot 25-normalized (4) stomach (3), ascites (2) 1257 bp exon 1732 bp exon 1732 bp exon 1732 bp exon Sequence gap 73122 bp 125 accessions, NM_012151.3 some from breast (seen 10 times) neuroblastoma cot 25-normalized (8) colon (7), lung (7), uterus (7) 699 bp exon Alternative mRNAs are shown aligned from 5' to 3' on a virtual genome where introns have been shrunk to a minimal length. Exon size is proportional to length, intron height reflects the number of cDNAs supporting each intron, the small numbers show the support of the introns in deep sequencing (with details in mouse-over) . Introns of the same color are identical, of different colors are different. 'Good proteins' are pink, partial or not-good proteins are yellow, uORFs are green. 5' cap or3' poly A flags show completeness of the transcript.
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Sequences: click on the numbers to get the DNA back to top
mRNA variant mRNA matching the genome Best predicted protein 5' UTR 3' UTR Upstream sequence Transcription
unit
pre-mRNA
Downstream sequence
aAug10-unspliced 1257 bp 418 aa 2kb 1257 bp 1kb
bAug10-unspliced 2460 bp 371 aa 40 bp 1304 bp 2kb 75553 bp 1kb

Gene neighbors and Navigator on chromosome Xq28 back to top
FUNDC2 C I R P BRCC3 D C I R P VBP1 D C I R P G R C H2AFB2 C P F8A2 C P G R SPRY3.1 C I P VAMP7.1 TWF1P2 D C I R P MTCP1NB D C R P RAB39B C I R P CLIC2 C P F8A3 C P H2AFB3 R G C C C I R P TMLHE P 100kb 0 FUNDC2, 442 accessions 12 variants BRCC3, 232 accessions 12 variants VBP1, 274 accessions, 6 variants LOC553939, 47 accessions 3 variants charbu, 46 accessions H2AFB2, 28 accessions 2 variants F8A2, 149 accessions, 2 variants LOC100288075, 1 accession skeyva, 20 accessions 7 variants SPRY3.1, 52 accessions 2 variants VAMP7.1, 430 accessions 14 variants swoynar, 1 accession beenaw, 1 accession jarmy, 1 accession kawvy, 11 accessions bornaw, 1 accession rawfo, 1 accession sufy, 1 accession perdoy, 1 accession jormy, 1 accession kamy, 1 accession karmy, 1 accession koymy, 6 accessions mora, 29 accessions donaw, 1 accession dornaw, 1 accession tufy, 1 accession funaw, 1 accession lymy, 1 accession lermy, 1 accession tawfy, 1 accession romy, 1 accession fleemy, 1 accession tawmy, 1 accession kirera, 3 accessions, 2 variants sawdoy, 1 accession woyfy, 1 accession chermy, 1 accession chamy, 1 accession serfo, 1 accession zamy, 2 accessions serdoy, 1 accession slobaw, 33 accessions 2 variants buno, 3 accessions teemy, 1 accession seymy, 1 accession borno, 1 accession joymu, 2 accessions ramu, 1 accession gasubo, 2 accessions samu, 1 accession klamu, 1 accession yurora, 1 accession tydoy, 1 accession blofy, 2 accessions heho, 1 accession blarfy, 1 accession rarfy, 1 accession swernar, 1 accession gumy, 1 accession gormy, 1 accession reefy, 1 accession bunaw, 1 accession danaw, 1 accession dynaw, 1 accession waho, 1 accession seefy, 1 accession keymy, 1 accession pordoy, 1 accession fanaw, 1 accession meyvar, 5 accessions riho, 1 accession tarfy, 1 accession larmy, 1 accession mermy, 1 accession moymy, 1 accession ruho, 1 accession permy, 1 accession rermy, 1 accession rormy, 1 accession radoy, 1 accession TWF1P2, 1 accession vorfy, 1 accession rardoy, 2 accessions symy, 1 accession fornaw, 1 accession flermy, 1 accession flarmy, 1 accession blomy, 3 accessions zawmy, 1 accession yuho, 1 accession weemy, 1 accession zomy, 1 accession zarmy, 2 accessions zormy, 1 accession swoynu, 1 accession tormy, 1 accession rorora, 3 accessions, 2 variants wyfy, 1 accession seydoy, 1 accession moho, 4 accessions soymy, 1 accession morvar, 5 accessions huho, 1 accession glamy, 1 accession boyno, 1 accession glymy, 2 accessions kloymy, 1 accession sordoy, 1 accession dano, 1 accession komu, 1 accession pomu, 1 accession nuvar, 3 accessions rumu, 1 accession soydoy, 1 accession sharmu, 1 accession bloyfy, 1 accession F8, 193 accessions, 11 variants MTCP1NB, 149 accessions 9 variants RAB39B, 91 accessions 2 variants CLIC2, 210 accessions 12 variants F8A3, 155 accessions, 2 variants H2AFB3, 28 accessions 2 variants gunaw, 18 accessions LOC100288106, 16 accessions hiho, 9 accessions TMLHE, 151 accessions 14 variants naho, 1 accession ZOOM IN                D:disease,C:conserved,I:interactions,R:regulation,P:publications         Read more...
Annotated mRNA diagrams back to top
Bibliography:               2 articles in PubMed back to top
? Gene Summary Gene on genome mRNA:.a-u, .b-u Alternative mRNAs features, proteins, introns, exons, sequences Expression Tissue Function, regulation, related genes C

To mine knowledge about the gene, please click the 'Gene Summary' or the 'Function, regulation, related genes ' tab at the top of the page. The 'Gene Summary' page includes all we learnt about the gene, functional annotations of neighboring genes, maps, links to other sites and the bibliography. The 'Function, regulation, related genes ' page includes Diseases (D), Pathways, GO annotations, conserved domains (C), interactions (I) reference into function, and pointers to all genes with the same functional annotation.
To compare alternative variants, their summarized annotations, predicted proteins, introns and exons, or to access any sequence, click the 'Alternative mRNAs features' tab. To see a specific mRNA variant diagram, sequence and annotation, click the variant name in the 'mRNA' tab. To examine expression data from all cDNAs clustered in this gene by AceView, click the 'Expression tissue'.

If you know more about this gene, or found errors, please share your knowledge. Thank you !