Homo sapiens complex locus ELAVL4, encoding ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D).
TABLE OF CONTENTS / OPEN CLOSE ALL PARAGRAPHS
SUMMARY back to top
RefSeq annotates 5 representative transcripts (NM included in AceView variants .a, .b, .c, .e and .f), but Homo sapiens cDNA sequences in GenBank, dbEST, Trace and SRA, filtered against clone rearrangements, coaligned on the genome and clustered in a minimal non-redundant way by the manually supervised AceView program, support at least 14 spliced variants.

AceView synopsis, each blue text links to tables and details
Note that this locus is complex: it appears to produce several proteins with no sequence overlap.
Expression: According to AceView, this gene is well expressed, 1.2 times the average gene in this release. The sequence of this gene is defined by 147 GenBank accessions from 125 cDNA clones, some from brain (seen 20 times), lung (11), carcinoid (10), pancreas (9), hypothalamus (6), insulinoma (5), neuroblastoma (5) and 32 other tissues. We annotate structural defects or features in 12 cDNA clones.
Alternative mRNA variants and regulation: The gene contains 18 distinct gt-ag introns. Transcription produces 14 alternatively spliced mRNAs. There are 6 probable alternative promotors, 3 non overlapping alternative last exons and 4 validated alternative polyadenylation sites (see the diagram). The mRNAs appear to differ by truncation of the 3' end, presence or absence of 3 cassette exons, overlapping exons with different boundaries.
Efficacy of translation may be reduced by the presence of a shorter translated product (uORF) initiating at an AUG upstream of the main open reading frame (in variant dAug10, eAug10).
Function: There are 32 articles specifically referring to this gene in PubMed. Functionally, the gene has been tested for association to diseases (Carcinoma, Small Cell; Encephalomyelitis; Lung Neoplasms; Macular Degeneration; Neoplasms; Neuroblastoma; Neuropathy, paraneoplastic sensory; Parkinson disease) and proposed to participate in a process (mRNA processing). Proteins are expected to have molecular functions (AU-rich element binding, mRNA 3'-UTR binding, RNA binding, nucleotide binding) and to localize in various compartments (cytoplasm, nucleus). Putative protein interactors have been described (ELAVL2, EWSR1, GAP43, NFX1, NXF1ANDTMEM223).
Protein coding potential: The 14 spliced mRNAs putatively encode good proteins, altogether 14 different isoforms (8 complete, 3 COOH complete, 3 partial), some containing RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) [Pfam]. Finally proteins from this gene may be modulated by methylation; phosphorylation; ubiquitination, as detailed at PhosphoSite.

Please quote: AceView: a comprehensive cDNA-supported gene and transcripts annotation, Genome Biology 2006, 7(Suppl 1):S12.
Map on chromosome 1, links to other databases and other names
Map: This gene ELAVL4 maps on chromosome 1, at 1p34 according to Entrez Gene. In AceView, it covers 155.77 kb, from 50513686 to 50669455 (NCBI 37, August 2010), on the direct strand.
Links to: , manual annotations from GAD, PhosphoSite, the SNP view, gene overviews from Entrez Gene 1996, GeneCards, expression data from ECgene, UniGene, molecular and other annotations from UCSC, or our GOLD analysis.
The previous AceView annotation is here.
Other names: The gene is also known as ELAVL4, HUD or PNEM, LOC1996. It has been described as ELAV-like protein 4, hu-antigen D, OTTHUMP00000009609, OTTHUMP00000009613, OTTHUMP00000009614, paraneoplastic encephalomyelitis antigen HuD, Embryonic lethal, abnormal vision, Drosophila, homolog of, like-4.
Closest AceView homologs in other species ?
The closest mouse genes, according to BlastP, are the AceView genes Elavl4 (e=0.0), Elavl2 (e= 10-178).
The closest C.elegans gene, according to BlastP, is the AceView/WormGene exc-7 (e=4 10-69), which may contain interesting functional annotation.
The closest A.thaliana genes, according to BlastP, are the AceView genes PAB8 (e=9 10-29), PAB2 (e=10-25), which may contain interesting functional annotation
RNA_seq discoveries back to top
Expression/conservation in primates tissues evaluated by cross-mapping to human. back to top
ELAVL4 Gene expression in 15 primates, 16 tissues, from the NHPRTR project in sFPKM BAB SkeletalMuscle WholeBlood CHP Kidney Liver Lung Spleen CMC CMM Cerebellum HUM Brain Colon Heart LymphNode Ovary Testis JMI BoneMarrow MLM OWL PTM RMC RMI Pituitary SQM Thymus MST SMY RTL 0.13 0.24 18.8 40.3 5.04 0.04 0.08 0.34 0.04 3.57 0.06 0.14 80.7 70.2 40.3 10.1 0.04 0.08 0.78 0.22 24.8 61.1 1.18 0.07 0.08 0.15 0.32 0.32 26.6 92.7 0.22 0.12 0.09 0.29 2.70 0.26 20.2 43.2 0.13 0.72 7.13 1.91 0.08 75.3 6.65 46.3 0.10 0.08 0.07 0.04 0.09 0.10 0.08 2.19 0.08 49.7 0.08 0.18 0.22 7.64 0.24 1.78 0.11 18.8 61.1 10.1 1.35 0.06 0.06 0.09 0.08 0.19 0.12 0.13 0.10 0.10 0.07 17.6 1.91 0.10 80.7 0.16 0.11 0.16 16.4 0.08 0.05 0.13 0.42 1.45 35.1 0.16 0.12 80.7 2.05 0.06 0.83 1.10 5.79 0.07 9.41 0.12 8.19 0.11 0.24 13.3 75.3 0.39 0.10 0.10 0.15 0.07 0.27 0.29 8.19 32.8 49.7 0.89 0.63 Expression quantiles None Weak 1 2 3 4 5 6 7 8 10 20 This gene All genes log2 distributions RNA-seq gene expression profile across 16 selected tissues from the Non-Human Primates Reference Transcriptome Resource (link to NHPRTR project).
- Primates: Apes (HUM: Human (Illumina BodyMap 2), CHP: Chimpanzee), Old World monkeys (PTM: Pig-Tailed Macaque, JMI Japanese Macaque, RMI Rhesus Macaque Indian, RMC Rhesus Macaque Chinese, CMM Cynomolgus Macaque Mauritian, CMC Cynomolgus Macaque Chinese, BAB Olive Baboon, SMY Sooty Mangabey); New World monkeys (MST common Marmoset, SQM Squirrel Monkey, OWL Owl Monkey); and Lemurs (MLM Mouse Lemur, RTL Ring-Tailed Lemur).
- The level for significantly expressed genes is color coded in 8 equal sized bins (light to dark green). Light gray is for weak not-accurately measured expression (2 to 8 reads above intergenic background); dark gray for no expression or no sequence conservation (0 read in gene). The plot to the right shows the distribution of measured expression values in all tissues for all genes (blue) and for this gene (green), in Magic index = log2(1000 sFPKM).
You may also examine the strand-specific genome coverage plots on the experimental AceView/Magic hub at UCSC, by tissue or by species. Tracks may be slow to load; please reload if some tracks come up yellow-greenish, and thanks to UCSC for the great work!.
Read more...
          Complete gene on genome diagram: back to top
Please choose between the zoomable GIF version., and the HTML5/SVG version.
This diagram shows in true scale the gene on the genome, the mRNAs and the cDNA clones.
Compact gene diagram back to top
Gene ELAVL4 5' 3' encoded on plus strand of chromosome 1 from 50,513,686 to 50,669,455 13752 273975 277162 305881 326592 292120 a [NM] 12861 273975 277162 305881 326592 292120 b [NM] 82831 273975 277162 305881 326592 30040 c [NM] 86920 273975 277162 305881 326592 292120 d 11532 273975 277162 305881 326592 292120 e [NM] 82831 273975 277162 305881 326592 292120 f [NM] 9041 32014 273975 277162 305881 326592 292120 g 86920 273975 277162 305881 326592 h 86920 2428 277162 305881 9456 i 12861 273975 24696 j 13752 273975 24696 k 82831 273975 24696 l 10591 32014 273975 m 140 32014 273975 n 1 2kb 0 169 bp exon 169 bp exon 96774 bp [gt-ag] intron 7 GenBank accessions 13745 RNA-seq supporting reads 325 Brain 13409 Neuroblastoma 11 Other (also 85 Primates bodymap) 241 bp exon 31891 bp [gt-ag] intron 55 GenBank accessions 273920 RNA-seq supporting reads 7 UHR pooled cells 12208 Brain 10 Blood 260884 Neuroblastoma 811 Other (also 3637 Primates bodymap) 104 bp exon 16572 bp [gt-ag] intron 49 GenBank accessions 277113 RNA-seq supporting reads 7 UHR pooled cells 12747 Brain 12 Blood 263590 Neuroblastoma 757 Other (also 3227 Primates bodymap) 154 bp exon 1642 bp [gt-ag] intron 34 GenBank accessions 305847 RNA-seq supporting reads 8 UHR pooled cells 12856 Brain 7 Blood 292206 Neuroblastoma 770 Other (also 2028 Primates bodymap) 226 bp exon 1642 bp [gt-ag] intron 33 GenBank accessions 326559 RNA-seq supporting reads 6 UHR pooled cells 14338 Brain 311427 Neuroblastoma 788 Other (also 2468 Primates bodymap) 39 bp exon 3383 bp [gt-ag] intron 28 GenBank accessions 292092 RNA-seq supporting reads 4 UHR pooled cells 13263 Brain 4 Blood 278013 Neuroblastoma 808 Other (also 2225 Primates bodymap) 1018 bp exon 22 accessions, NM_001144777.1 some from brain (seen 5 times) neuroblastoma cot 25-normalized (4) carcinoid (2), lung (2) neuroblastoma cells (2) Validated 3' end, 1 accession 1018 bp exon 120 bp exon 38563 bp [gt-ag] intron 4 GenBank accessions 12857 RNA-seq supporting reads 168 Brain 12590 Neuroblastoma 99 Other (also 25 Primates bodymap) 241 bp exon 31891 bp [gt-ag] intron 55 GenBank accessions 273920 RNA-seq supporting reads 7 UHR pooled cells 12208 Brain 10 Blood 260884 Neuroblastoma 811 Other (also 3637 Primates bodymap) 104 bp exon 16572 bp [gt-ag] intron 49 GenBank accessions 277113 RNA-seq supporting reads 7 UHR pooled cells 12747 Brain 12 Blood 263590 Neuroblastoma 757 Other (also 3227 Primates bodymap) 154 bp exon 1642 bp [gt-ag] intron 34 GenBank accessions 305847 RNA-seq supporting reads 8 UHR pooled cells 12856 Brain 7 Blood 292206 Neuroblastoma 770 Other (also 2028 Primates bodymap) 226 bp exon 1642 bp [gt-ag] intron 33 GenBank accessions 326559 RNA-seq supporting reads 6 UHR pooled cells 14338 Brain 311427 Neuroblastoma 788 Other (also 2468 Primates bodymap) 39 bp exon 3383 bp [gt-ag] intron 28 GenBank accessions 292092 RNA-seq supporting reads 4 UHR pooled cells 13263 Brain 4 Blood 278013 Neuroblastoma 808 Other (also 2225 Primates bodymap) 1018 bp exon 3 accessions, NM_001144775.1 some from insulinoma (seen once) neuroblastoma (once) pancreas (once) 1018 bp exon 277 bp exon 277 bp exon 35758 bp [gt-ag] intron 22 GenBank accessions 82809 RNA-seq supporting reads 4 UHR pooled cells 4685 Brain 2 Blood 77948 Neuroblastoma 170 Other (also 1626 Primates bodymap) 241 bp exon 31891 bp [gt-ag] intron 55 GenBank accessions 273920 RNA-seq supporting reads 7 UHR pooled cells 12208 Brain 10 Blood 260884 Neuroblastoma 811 Other (also 3637 Primates bodymap) 104 bp exon 16572 bp [gt-ag] intron 49 GenBank accessions 277113 RNA-seq supporting reads 7 UHR pooled cells 12747 Brain 12 Blood 263590 Neuroblastoma 757 Other (also 3227 Primates bodymap) 154 bp exon 1642 bp [gt-ag] intron 34 GenBank accessions 305847 RNA-seq supporting reads 8 UHR pooled cells 12856 Brain 7 Blood 292206 Neuroblastoma 770 Other (also 2028 Primates bodymap) 226 bp exon 1642 bp [gt-ag] intron 33 GenBank accessions 326559 RNA-seq supporting reads 6 UHR pooled cells 14338 Brain 311427 Neuroblastoma 788 Other (also 2468 Primates bodymap) 39 bp exon 3341 bp [gt-ag] intron 3 GenBank accessions 30037 RNA-seq supporting reads 1228 Brain 28759 Neuroblastoma 50 Other (also 282 Primates bodymap) 1060 bp exon 3 accessions, NM_021952.3 some from cerebellum (seen once) neuroblastoma (once) 1060 bp exon 349 bp exon 349 bp exon 117 bp uORF 349 bp exon 349 bp exon 34992 bp [gt-ag] intron 24 GenBank accessions 86896 RNA-seq supporting reads 2 UHR pooled cells 3565 Brain 10 Blood 83184 Neuroblastoma 135 Other (also 1361 Primates bodymap) 241 bp exon 241 bp exon 31891 bp [gt-ag] intron 55 GenBank accessions 273920 RNA-seq supporting reads 7 UHR pooled cells 12208 Brain 10 Blood 260884 Neuroblastoma 811 Other (also 3637 Primates bodymap) 104 bp exon 104 bp exon 16572 bp [gt-ag] intron 49 GenBank accessions 277113 RNA-seq supporting reads 7 UHR pooled cells 12747 Brain 12 Blood 263590 Neuroblastoma 757 Other (also 3227 Primates bodymap) 154 bp exon 154 bp exon 1642 bp [gt-ag] intron 34 GenBank accessions 305847 RNA-seq supporting reads 8 UHR pooled cells 12856 Brain 7 Blood 292206 Neuroblastoma 770 Other (also 2028 Primates bodymap) 226 bp exon 226 bp exon 1642 bp [gt-ag] intron 33 GenBank accessions 326559 RNA-seq supporting reads 6 UHR pooled cells 14338 Brain 311427 Neuroblastoma 788 Other (also 2468 Primates bodymap) 39 bp exon 39 bp exon 3383 bp [gt-ag] intron 28 GenBank accessions 292092 RNA-seq supporting reads 4 UHR pooled cells 13263 Brain 4 Blood 278013 Neuroblastoma 808 Other (also 2225 Primates bodymap) 2330 bp exon 2330 bp exon 8 accessions, some from brain (seen 3 times) eye (once), fetal brain (once) fetal eyes (once) 2330 bp exon 91 bp exon 91 bp exon 66 bp uORF 91 bp exon 40956 bp [gt-ag] intron 2 GenBank accessions 11530 RNA-seq supporting reads 11530 Neuroblastoma (also 5 Primates bodymap) 66 bp uORF 241 bp exon 241 bp exon 31891 bp [gt-ag] intron 55 GenBank accessions 273920 RNA-seq supporting reads 7 UHR pooled cells 12208 Brain 10 Blood 260884 Neuroblastoma 811 Other (also 3637 Primates bodymap) 104 bp exon 104 bp exon 16572 bp [gt-ag] intron 49 GenBank accessions 277113 RNA-seq supporting reads 7 UHR pooled cells 12747 Brain 12 Blood 263590 Neuroblastoma 757 Other (also 3227 Primates bodymap) 154 bp exon 154 bp exon 1642 bp [gt-ag] intron 34 GenBank accessions 305847 RNA-seq supporting reads 8 UHR pooled cells 12856 Brain 7 Blood 292206 Neuroblastoma 770 Other (also 2028 Primates bodymap) 226 bp exon 226 bp exon 1642 bp [gt-ag] intron 33 GenBank accessions 326559 RNA-seq supporting reads 6 UHR pooled cells 14338 Brain 311427 Neuroblastoma 788 Other (also 2468 Primates bodymap) 39 bp exon 39 bp exon 3383 bp [gt-ag] intron 28 GenBank accessions 292092 RNA-seq supporting reads 4 UHR pooled cells 13263 Brain 4 Blood 278013 Neuroblastoma 808 Other (also 2225 Primates bodymap) 1018 bp exon 1018 bp exon 2 accessions, NM_001144776.1 some from neuroblastoma (seen once) 1018 bp exon 279 bp exon 279 bp exon 35758 bp [gt-ag] intron 22 GenBank accessions 82809 RNA-seq supporting reads 4 UHR pooled cells 4685 Brain 2 Blood 77948 Neuroblastoma 170 Other (also 1626 Primates bodymap) 241 bp exon 31891 bp [gt-ag] intron 55 GenBank accessions 273920 RNA-seq supporting reads 7 UHR pooled cells 12208 Brain 10 Blood 260884 Neuroblastoma 811 Other (also 3637 Primates bodymap) 104 bp exon 16572 bp [gt-ag] intron 49 GenBank accessions 277113 RNA-seq supporting reads 7 UHR pooled cells 12747 Brain 12 Blood 263590 Neuroblastoma 757 Other (also 3227 Primates bodymap) 154 bp exon 1642 bp [gt-ag] intron 34 GenBank accessions 305847 RNA-seq supporting reads 8 UHR pooled cells 12856 Brain 7 Blood 292206 Neuroblastoma 770 Other (also 2028 Primates bodymap) 226 bp exon 1642 bp [gt-ag] intron 33 GenBank accessions 326559 RNA-seq supporting reads 6 UHR pooled cells 14338 Brain 311427 Neuroblastoma 788 Other (also 2468 Primates bodymap) 39 bp exon 3383 bp [gt-ag] intron 28 GenBank accessions 292092 RNA-seq supporting reads 4 UHR pooled cells 13263 Brain 4 Blood 278013 Neuroblastoma 808 Other (also 2225 Primates bodymap) 2933 bp exon 50 accessions, NM_001144774.1 some from brain (seen 6 times) hypothalamus (5), lung (4) whole brain (4), carcinoid (3) 2933 bp exon 149 bp exon 31807 bp [gt-ag] intron 2 GenBank accessions 9039 RNA-seq supporting reads 231 Brain 1 Blood 8784 Neuroblastoma 23 Other (also 41 Primates bodymap) 87 bp exon 87 bp exon 3098 bp [gt-ag] intron 5 GenBank accessions 32009 RNA-seq supporting reads 816 Brain 2 Blood 31116 Neuroblastoma 75 Other (also 110 Primates bodymap) 241 bp exon 31891 bp [gt-ag] intron 55 GenBank accessions 273920 RNA-seq supporting reads 7 UHR pooled cells 12208 Brain 10 Blood 260884 Neuroblastoma 811 Other (also 3637 Primates bodymap) 104 bp exon 16572 bp [gt-ag] intron 49 GenBank accessions 277113 RNA-seq supporting reads 7 UHR pooled cells 12747 Brain 12 Blood 263590 Neuroblastoma 757 Other (also 3227 Primates bodymap) 154 bp exon 1642 bp [gt-ag] intron 34 GenBank accessions 305847 RNA-seq supporting reads 8 UHR pooled cells 12856 Brain 7 Blood 292206 Neuroblastoma 770 Other (also 2028 Primates bodymap) 226 bp exon 1642 bp [gt-ag] intron 33 GenBank accessions 326559 RNA-seq supporting reads 6 UHR pooled cells 14338 Brain 311427 Neuroblastoma 788 Other (also 2468 Primates bodymap) 39 bp exon 3383 bp [gt-ag] intron 28 GenBank accessions 292092 RNA-seq supporting reads 4 UHR pooled cells 13263 Brain 4 Blood 278013 Neuroblastoma 808 Other (also 2225 Primates bodymap) 540 bp exon 2 accessions 540 bp exon 124 bp exon 124 bp exon 34992 bp [gt-ag] intron 24 GenBank accessions 86896 RNA-seq supporting reads 2 UHR pooled cells 3565 Brain 10 Blood 83184 Neuroblastoma 135 Other (also 1361 Primates bodymap) 241 bp exon 31891 bp [gt-ag] intron 55 GenBank accessions 273920 RNA-seq supporting reads 7 UHR pooled cells 12208 Brain 10 Blood 260884 Neuroblastoma 811 Other (also 3637 Primates bodymap) 104 bp exon 16572 bp [gt-ag] intron 49 GenBank accessions 277113 RNA-seq supporting reads 7 UHR pooled cells 12747 Brain 12 Blood 263590 Neuroblastoma 757 Other (also 3227 Primates bodymap) 154 bp exon 1642 bp [gt-ag] intron 34 GenBank accessions 305847 RNA-seq supporting reads 8 UHR pooled cells 12856 Brain 7 Blood 292206 Neuroblastoma 770 Other (also 2028 Primates bodymap) 226 bp exon 1642 bp [gt-ag] intron 33 GenBank accessions 326559 RNA-seq supporting reads 6 UHR pooled cells 14338 Brain 311427 Neuroblastoma 788 Other (also 2468 Primates bodymap) 157 bp exon 2 accessions Validated 3' end, 1 accession 157 bp exon 33 bp exon 33 bp exon 288 bp uORF 34992 bp [gt-ag] intron 24 GenBank accessions 86896 RNA-seq supporting reads 2 UHR pooled cells 3565 Brain 10 Blood 83184 Neuroblastoma 135 Other (also 1361 Primates bodymap) 241 bp exon 288 bp uORF 31896 bp [gt-ag] intron 2 GenBank accessions 2426 RNA-seq supporting reads 58 Brain 2361 Neuroblastoma 7 Other 288 bp uORF 99 bp exon 99 bp exon 16572 bp [gt-ag] intron 49 GenBank accessions 277113 RNA-seq supporting reads 7 UHR pooled cells 12747 Brain 12 Blood 263590 Neuroblastoma 757 Other (also 3227 Primates bodymap) 154 bp exon 154 bp exon 154 bp exon 1642 bp [gt-ag] intron 34 GenBank accessions 305847 RNA-seq supporting reads 8 UHR pooled cells 12856 Brain 7 Blood 292206 Neuroblastoma 770 Other (also 2028 Primates bodymap) 226 bp exon 226 bp exon 5064 bp [gt-ag] intron 1 GenBank accession 9455 RNA-seq supporting reads 4 UHR pooled cells 608 Brain 8819 Neuroblastoma 24 Other (also 200 Primates bodymap) 551 bp exon 551 bp exon 3 accessions, some from eye (seen 2 times) fetal eyes (2) 551 bp exon 129 bp exon 38563 bp [gt-ag] intron 4 GenBank accessions 12857 RNA-seq supporting reads 168 Brain 12590 Neuroblastoma 99 Other (also 25 Primates bodymap) 241 bp exon 31891 bp [gt-ag] intron 55 GenBank accessions 273920 RNA-seq supporting reads 7 UHR pooled cells 12208 Brain 10 Blood 260884 Neuroblastoma 811 Other (also 3637 Primates bodymap) 104 bp exon 2351 bp [gt-ag] intron 3 GenBank accessions 24693 RNA-seq supporting reads 187 Brain 24470 Neuroblastoma 36 Other (also 9 Primates bodymap) 1 accession from insulinoma from pancreas 6 bp exon 128 bp exon 128 bp exon 96774 bp [gt-ag] intron 7 GenBank accessions 13745 RNA-seq supporting reads 325 Brain 13409 Neuroblastoma 11 Other (also 85 Primates bodymap) 241 bp exon 31891 bp [gt-ag] intron 55 GenBank accessions 273920 RNA-seq supporting reads 7 UHR pooled cells 12208 Brain 10 Blood 260884 Neuroblastoma 811 Other (also 3637 Primates bodymap) 104 bp exon 2351 bp [gt-ag] intron 3 GenBank accessions 24693 RNA-seq supporting reads 187 Brain 24470 Neuroblastoma 36 Other (also 9 Primates bodymap) 80 bp exon 1 accession capped 5' end, 1 accession 80 bp exon 16 bp exon 16 bp exon 35758 bp [gt-ag] intron 22 GenBank accessions 82809 RNA-seq supporting reads 4 UHR pooled cells 4685 Brain 2 Blood 77948 Neuroblastoma 170 Other (also 1626 Primates bodymap) 241 bp exon 31891 bp [gt-ag] intron 55 GenBank accessions 273920 RNA-seq supporting reads 7 UHR pooled cells 12208 Brain 10 Blood 260884 Neuroblastoma 811 Other (also 3637 Primates bodymap) 104 bp exon 2351 bp [gt-ag] intron 3 GenBank accessions 24693 RNA-seq supporting reads 187 Brain 24470 Neuroblastoma 36 Other (also 9 Primates bodymap) 1755 bp exon 16 accessions, some from carcinoid (seen 5 times) lung (5), pancreas (3) insulinoma (2), eye (once) Validated 3' end, 7 accessions Validated 3' end, 1 accession 1755 bp exon 282 bp exon 282 bp exon 36 bp uORF 32573 bp [gt-ag] intron 2 GenBank accessions 10589 RNA-seq supporting reads 257 Brain 10319 Neuroblastoma 13 Other (also 50 Primates bodymap) 36 bp uORF 87 bp exon 87 bp exon 87 bp exon 3098 bp [gt-ag] intron 5 GenBank accessions 32009 RNA-seq supporting reads 816 Brain 2 Blood 31116 Neuroblastoma 75 Other (also 110 Primates bodymap) 241 bp exon 241 bp exon 31891 bp [gt-ag] intron 55 GenBank accessions 273920 RNA-seq supporting reads 7 UHR pooled cells 12208 Brain 10 Blood 260884 Neuroblastoma 811 Other (also 3637 Primates bodymap) 39 bp exon 39 bp exon 3 accessions, some from brain (seen once) brain/cns (once), human brain - frontal cortex (once) 39 bp exon 229 bp exon 21755 bp [gt-ag] intron 1 GenBank accession 139 RNA-seq supporting reads 139 Neuroblastoma 87 bp exon 87 bp exon 3098 bp [gt-ag] intron 5 GenBank accessions 32009 RNA-seq supporting reads 816 Brain 2 Blood 31116 Neuroblastoma 75 Other (also 110 Primates bodymap) 241 bp exon 31891 bp [gt-ag] intron 55 GenBank accessions 273920 RNA-seq supporting reads 7 UHR pooled cells 12208 Brain 10 Blood 260884 Neuroblastoma 811 Other (also 3637 Primates bodymap) 31 bp exon 1 accession from testis 31 bp exon Alternative mRNAs are shown aligned from 5' to 3' on a virtual genome where introns have been shrunk to a minimal length. Exon size is proportional to length, intron height reflects the number of cDNAs supporting each intron, the small numbers show the support of the introns in deep sequencing (with details in mouse-over) . Introns of the same color are identical, of different colors are different. 'Good proteins' are pink, partial or not-good proteins are yellow, uORFs are green. 5' cap or3' poly A flags show completeness of the transcript.
Read more...
Sequences: click on the numbers to get the DNA back to top
mRNA variant mRNA matching the genome Best predicted protein 5' UTR 3' UTR uORF Upstream sequence Transcription
unit
pre-mRNA		 Downstream sequence
aAug10 1951 bp 419 aa 690 bp 2kb 153855 bp 1kb
bAug10 1902 bp 403 aa 690 bp 2kb 95595 bp 1kb
cAug10 2101 bp 380 aa 268 bp 690 bp 2kb probably including promoter 92947 bp 1kb
dAug10 3443 bp 371 aa 325 bp 2002 bp 114 bp 2kb possibly including promoter 93565 bp 1kb
eAug10 1873 bp 366 aa 82 bp 690 bp 63 bp 2kb possibly including promoter 97959 bp 1kb
fAug10 3976 bp 366 aa 270 bp 2605 bp 2kb probably including promoter 94864 bp 1kb
gAug10 1540 bp 365 aa 230 bp 212 bp 2kb possibly including promoter 91575 bp 1kb
hAug10 1006 bp 263 aa 100 bp 114 bp 2kb possibly including promoter 87745 bp 1kb
iAug10 1304 bp 211 aa 445 bp 223 bp 285 bp 2kb possibly including promoter 91470 bp 1kb
jAug10 480 bp 160 aa 2kb 73285 bp 1kb
kAug10 553 bp 131 aa 110 bp 47 bp 2kb including Promoter 131569 bp 1kb
lAug10 2116 bp 130 aa 1722 bp 2kb 72116 bp 1kb
mAug10 649 bp 95 aa 363 bp 33 bp 2kb probably including promoter 68211 bp 1kb
nAug10 588 bp 92 aa 310 bp 2kb possibly including promoter 57332 bp 1kb

Gene neighbors and Navigator on chromosome 1p34 back to top
ELAVL4 D C I R P R R C R P DMRTA2 100kb 0 ELAVL4, 130 accessions 14 variants smarboy, 4 accessions 2 variants plawmybo, 1 accession zarzarbo, 1 accession korpawbu, 1 accession seyplo, 2 accessions lypawbu, 2 accessions lupawbu, 1 accession lopawbu, 1 accession larpawbu, 1 accession hawaha, 2 accessions, 2 variants smermawbu, 1 accession lerpawbu, 3 accessions taplo, 2 accessions skomybo, 2 accessions hiwaha, 2 accessions, 2 variants smormawbu, 1 accession toplo, 1 accession mapawbu, 1 accession mypawbu, 1 accession mawpawbu, 5 accessions merpawbu, 1 accession snoymawbu, 1 accession zerzarbo, 1 accession spamawbu, 1 accession nypawbu, 1 accession nopawbu, 2 accessions narpawbu, 2 accessions zeyzarbo, 1 accession nawpawbu, 1 accession neepawbu, 2 accessions jywybo, 1 accession popawbu, 1 accession parpawbu, 1 accession karpawbu, 1 accession swarkubo, 4 accessions kerpawbu, 1 accession sporfeybu, 2 accessions lapawbu, 4 accessions peyloy, 4 accessions pleemybo, 1 accession porloy, 1 accession zawzarbo, 1 accession plermybo, 1 accession pleymybo, 1 accession mosumo, 2 accessions, 2 variants plormybo, 1 accession lawpawbu, 1 accession soyplo, 2 accessions sleyboy, 3 accessions leepawbu, 1 accession sloyboy, 2 accessions typlo, 1 accession leypawbu, 1 accession lorpawbu, 1 accession skymybo, 1 accession raloy, 1 accession smeymawbu, 1 accession zeezarbo, 1 accession loypawbu, 1 accession weereybo, 3 accessions tawplo, 3 accessions marpawbu, 4 accessions meepawbu, 3 accessions weyreybo, 1 accession worreybo, 1 accession huwaha, 2 accessions napawbu, 1 accession nupawbu, 1 accession spymawbu, 1 accession zorzarbo, 1 accession zoyzarbo, 1 accession chazarbo, 1 accession neypawbu, 1 accession norpawbu, 1 accession noypawbu, 1 accession pypawbu, 1 accession spumawbu, 1 accession chyzarbo, 1 accession spomawbu, 1 accession AGBL4, 41 accessions, 7 variants smaboy, 9 accessions, 3 variants DMRTA2, 27 accessions 3 variants FAF1, 576 accessions, 13 variants ZOOM IN                D:disease,C:conserved,I:interactions,R:regulation,P:publications         Read more...
Annotated mRNA diagrams back to top
Bibliography:               32 articles in PubMed back to top
? Gene Summary Gene on genome mRNA:.a, .b, .c, .d, .e, .f, .g, .h, .i, .j, .k, .l, .m, .n Alternative mRNAs features, proteins, introns, exons, sequences Expression Tissue Function, regulation, related genes DCI

To mine knowledge about the gene, please click the 'Gene Summary' or the 'Function, regulation, related genes ' tab at the top of the page. The 'Gene Summary' page includes all we learnt about the gene, functional annotations of neighboring genes, maps, links to other sites and the bibliography. The 'Function, regulation, related genes ' page includes Diseases (D), Pathways, GO annotations, conserved domains (C), interactions (I) reference into function, and pointers to all genes with the same functional annotation.
To compare alternative variants, their summarized annotations, predicted proteins, introns and exons, or to access any sequence, click the 'Alternative mRNAs features' tab. To see a specific mRNA variant diagram, sequence and annotation, click the variant name in the 'mRNA' tab. To examine expression data from all cDNAs clustered in this gene by AceView, click the 'Expression tissue'.

If you know more about this gene, or found errors, please share your knowledge. Thank you !