last updated October 16, 2012
June 30th, 2007: New and enhanced releases of the Human, Mouse Arabidopsis and C. elegans genes, with more in depth biological and molecular annotation, using GenBank/dbEST/Trace cDNA data from March 26th, 2007 for human and June 22, 2007 for mouse have been made public…
AceView provides a curated, comprehensive and non-redundant sequence representation of all public mRNA sequences (mRNAs from GenBank or RefSeq, and single pass cDNA sequences from dbEST and Trace). These experimental cDNA sequences are first co-aligned on the genome then clustered into a minimal number of alternative transcript variants and grouped into genes. Using exhaustively and with high quality standards the available cDNA sequences evidences the beauty and complexity of mammals’ transcriptome, and the relative simplicity of the nematode and plant transcriptomes. Genes are classified according to their inferred coding potential; many presumably non-coding genes are discovered. Genes are named by Entrez Gene names when available, else by AceView gene names, stable from release to release.
Alternative features (promoters, introns and exons, polyadenylation signals) and coding potential, including motifs, domains, and homologies are annotated in depth; tissues where expression has been observed are listed in order of representation; diseases, phenotypes, pathways, functions, localization or interactions are annotated by mining selected sources, in particular PubMed, GAD and Entrez Gene, and also by performing manual annotation, especially in the worm.
In this way, both the anatomy and physiology of the experimentally cDNA supported human, mouse and nematode genes are thoroughly annotated.
Our goals are to offer an up-to-date resource on the genes, in the hope to stimulate further experiments at the bench, or to help medical research.
AceView can be queried by meaningful words or groups of words as well as by most standard identifiers, such as gene names, Entrez Gene ID, UniGene ID, GenBank accessions.
This work is in continuous development, please send us your wishes, comments, and bug reports.
If you wish to receive an announcement when we update the data on the site, please mail us.
To learn more about AceView, you may enjoy these documents:
· Danielle Thierry-Mieg and Jean Thierry-Mieg, AceView: a comprehensive cDNA-supported gene and transcripts annotation, Genome Biology 2006, 7(Suppl 1):S12
To get help, please see these:
· Frequently asked questions (updated Sept 13, 2005)
· Help with texts, tables, displays:
o the “Gene on Genome” page (updated July, 2007)
o the“Annotated mRNA” page (updated May 2006)