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HomoloGene:7266. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

VSX2,  H.sapiens
visual system homeobox 2
NP_878314.1
361 aa
VSX2,  P.troglodytes
visual system homeobox 2
XP_001156350.1
361 aa
VSX2,  M.mulatta
visual system homeobox 2-like
XP_001093608.1
361 aa
VSX2,  C.lupus
visual system homeobox 2
XP_547902.3
361 aa
VSX2,  B.taurus
visual system homeobox 2
NP_001180179.1
361 aa
Vsx2,  M.musculus
visual system homeobox 2
NP_031727.1
361 aa
Vsx2,  R.norvegicus
visual system homeobox 2
NP_001162599.1
361 aa
VSX2,  G.gallus
visual system homeobox 2
NP_990099.1
377 aa
vsx2,  X.tropicalis
visual system homeobox 2
XP_004917101.1
377 aa
vsx2,  D.rerio
visual system homeobox 2
NP_571537.2
372 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Microphthalmia, isolated, with coloboma 3.
Microphthalmia, isolated 2.



Publications
Articles associated with genes and sequences of this homology group.

VSX2 mutations in autosomal recessive microphthalmia.
Reis LM, et al. Mol Vis 17, 2527-32 (2011).
In mice lacking V2a interneurons, gait depends on speed of locomotion.
Crone SA, et al. J Neurosci 29, 7098-109 (2009).
Absence of chx10 causes neural progenitors to persist in the adult retina.
Dhomen NS, et al. Invest Ophthalmol Vis Sci 47, 386-96 (2006).
A gene causing ocular retardation in the mouse.
TRUSLOVE GM. J Embryol Exp Morphol 10, 652-60 (1962).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
OAR (pfam03826)
  OAR domain.
OAR (pfam03826)
  OAR domain.
homeodomain (cl00084)
  Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Vsx2 includes H.sapiens VSX2 and R.norvegicus Vsx2.

 

 

 

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