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HomoloGene:57160. Gene conserved in Amniota Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

KALRN,  H.sapiens
kalirin, RhoGEF kinase
2986 aa
KALRN,  M.mulatta
kalirin, RhoGEF kinase
2962 aa
KALRN,  C.lupus
kalirin, RhoGEF kinase
2987 aa
KALRN,  B.taurus
kalirin, RhoGEF kinase
2986 aa
Kalrn,  M.musculus
kalirin, RhoGEF kinase
2982 aa
Kalrn,  R.norvegicus
kalirin, RhoGEF kinase
2977 aa
KALRN,  G.gallus
kalirin, RhoGEF kinase
2964 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Phenotypic information for the genes in this entry imported from model organism databases.


Articles associated with genes and sequences of this homology group.

Structural organization of the nine spectrin repeats of Kalirin.
Vishwanatha KS, et al. Biochemistry 51, 5663-73 (2012).
Kalirin signaling: implications for synaptic pathology.
Penzes P & Remmers C. Mol Neurobiol 45, 109-18 (2012).
Kalirin-7 is necessary for normal NMDA receptor-dependent synaptic plasticity.
Lemtiri-Chlieh F, et al. BMC Neurosci 12, 126 (2011).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PH_TRIO (cd01232)
  Trio pleckstrin homology (PH) domain.
I-set (pfam07679)
  Immunoglobulin I-set domain.
PH-like (cl00273)
  Pleckstrin homology-like domain.
S_TKc (smart00220)
  Serine/Threonine protein kinases, catalytic domain.
SPEC (cd00176)
  Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
Extensin_2 (pfam04554)
  Extensin-like region.
I-set (pfam07679)
  Immunoglobulin I-set domain.
FN3 (cl00065)
  Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
Spectrin (cl02488)
  Spectrin repeat.
RhoGEF (cl02571)
  Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
SEC14 (cl15787)
  Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...
SH3 (cl17036)
  Src Homology 3 domain superfamily.
PH-like (cl17171)
  Pleckstrin homology-like domain.

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Kalrn includes H.sapiens KALRN and R.norvegicus Kalrn.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (27 transcripts, 10 species)
Actinopterygii - bony fishes (22 transcripts, 5 species)
Aves - birds (6 transcripts, 1 species)
Amphibia - amphibians (4 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)

Gastropoda - gastropods (2 transcripts, 1 species)

Anthozoa - anthozoans (2 transcripts, 1 species)

Insecta - insects (1 transcript, 1 species)

Trematoda - flatworms (1 transcript, 1 species)

Polychaeta - segmented worms (1 transcript, 1 species)

Echinoidea - sea urchins (1 transcript, 1 species)




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